Targeted intervention of eIF4A1 inhibits EMT and metastasis of pancreatic cancer cells via c-MYC/miR-9 signaling

Targeted intervention of eIF4A1 inhibits EMT and metastasis of pancreatic cancer cells via c-MYC/miR-9 signaling

Abstract Background Owing to the lack of effective treatment options, early metastasis remains the major cause of pancreatic ductal adenocarcinoma (PDAC) recurrence and mortality. However, the molecular mechanism of early metastasis is largely unknown. We characterized the function of eukaryotic tra...

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Bibliographic Details
Main Authors: Yuchong Zhao, Yun Wang, Wei Chen, Shuya Bai, Wang Peng, Mengli Zheng, Yilei Yang, Bin Cheng, Zhou Luan
Format: Article
Language:English
Published: BMC 2021-12-01
Series:Cancer Cell International
Subjects:
Eukaryotic translation initiation factor 4A1
c-MYC
Epithelial-mesenchymal transition
Rocaglamide
Mycro3
Online Access:https://doi.org/10.1186/s12935-021-02390-0

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