Reduction of serum cholesterol in hypercholesterolemic rats by Guar gum
Objective: Several diseases are reported to be uncommon in those parts of the world where dietary fiber intakes are high, therefore, in this study; we evaluated the hypocholesterolemiceffects of a dietary fiber (guar gum) in hypercholesteromic rats. Materials and Methods: Rats were fed high-fat or a...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2011-07-01
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| Series: | Avicenna Journal of Phytomedicine |
| Subjects: | |
| Online Access: | http://ajp.mums.ac.ir/pdf_119_58fefb58b324706d47c6932e374866a6.html |
| _version_ | 1818016487736082432 |
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| author | Saeed Samarghandian Mosa-Al-Reza Hadjzadeh Atiyeh Sadat Davari Marziyeh Abachi |
| author_facet | Saeed Samarghandian Mosa-Al-Reza Hadjzadeh Atiyeh Sadat Davari Marziyeh Abachi |
| author_sort | Saeed Samarghandian |
| collection | DOAJ |
| description | Objective: Several diseases are reported to be uncommon in those parts of the world where dietary fiber intakes are high, therefore, in this study; we evaluated the hypocholesterolemiceffects of a dietary fiber (guar gum) in hypercholesteromic rats.
Materials and Methods: Rats were fed high-fat or a normal fed diet for 12-week then treated with 5% guar gum in their regime during a 28 days period.
Results: Total cholesterol was significantly increased in high-fat diet rats, while administration of guar gum significantly lowered it. Body weight was significantly increased in high-fat diet rats while, at the end of 4-weeks treatment of guar gum, body weight of treated rats was significantly decreased.
Conclusion: These results suggested that guar gum may be effective as hypocholesterolemic agent and may prevent hypercholesteromia in hypercholesteromic rats. The results also suggested that guar gum may be important for reducing body weight in hyperlipidemic rats. |
| first_indexed | 2024-04-14T07:14:10Z |
| format | Article |
| id | doaj.art-efc6698c47a043ef918b426c04e8e83d |
| institution | Directory Open Access Journal |
| issn | 2228-7930 2228-7949 |
| language | English |
| last_indexed | 2024-04-14T07:14:10Z |
| publishDate | 2011-07-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj.art-efc6698c47a043ef918b426c04e8e83d2022-12-22T02:06:22ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492011-07-01113642119Reduction of serum cholesterol in hypercholesterolemic rats by Guar gumSaeed Samarghandian0Mosa-Al-Reza Hadjzadeh1Atiyeh Sadat Davari2Marziyeh Abachi3Department of Physiology, School of Medicine, Mashhad University Medical Sciences, Mashhad, I. R. IranDepartment of Physiology, School of Medicine, Mashhad University Medical Sciences, Mashhad, I. R. IranDepartment of Physiology, School of Medicine, Mashhad University Medical Sciences, Mashhad, I. R. IranDepartment of Biology, School of Sciences, Islamic Azad University, Mashhad Branch, I. R. IranObjective: Several diseases are reported to be uncommon in those parts of the world where dietary fiber intakes are high, therefore, in this study; we evaluated the hypocholesterolemiceffects of a dietary fiber (guar gum) in hypercholesteromic rats. Materials and Methods: Rats were fed high-fat or a normal fed diet for 12-week then treated with 5% guar gum in their regime during a 28 days period. Results: Total cholesterol was significantly increased in high-fat diet rats, while administration of guar gum significantly lowered it. Body weight was significantly increased in high-fat diet rats while, at the end of 4-weeks treatment of guar gum, body weight of treated rats was significantly decreased. Conclusion: These results suggested that guar gum may be effective as hypocholesterolemic agent and may prevent hypercholesteromia in hypercholesteromic rats. The results also suggested that guar gum may be important for reducing body weight in hyperlipidemic rats.http://ajp.mums.ac.ir/pdf_119_58fefb58b324706d47c6932e374866a6.htmlDietary fiberGuar gumHypercholesteromicLipid profileRat |
| spellingShingle | Saeed Samarghandian Mosa-Al-Reza Hadjzadeh Atiyeh Sadat Davari Marziyeh Abachi Reduction of serum cholesterol in hypercholesterolemic rats by Guar gum Avicenna Journal of Phytomedicine Dietary fiber Guar gum Hypercholesteromic Lipid profile Rat |
| title | Reduction of serum cholesterol in hypercholesterolemic rats by Guar gum |
| title_full | Reduction of serum cholesterol in hypercholesterolemic rats by Guar gum |
| title_fullStr | Reduction of serum cholesterol in hypercholesterolemic rats by Guar gum |
| title_full_unstemmed | Reduction of serum cholesterol in hypercholesterolemic rats by Guar gum |
| title_short | Reduction of serum cholesterol in hypercholesterolemic rats by Guar gum |
| title_sort | reduction of serum cholesterol in hypercholesterolemic rats by guar gum |
| topic | Dietary fiber Guar gum Hypercholesteromic Lipid profile Rat |
| url | http://ajp.mums.ac.ir/pdf_119_58fefb58b324706d47c6932e374866a6.html |
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