3D printing of porous Ti6Al4V bone tissue engineering scaffold and surface anodization preparation of nanotubes to enhance its biological property
Porous structures and surface morphology of bone tissue scaffolds play an important role in improving the biocompatibility and antibacterial properties for bone repair. In this study, we investigated the effect of different anodic oxidation parameters on the nanotubes morphology in 3D printed porous...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2023-07-01
|
| Series: | Nanotechnology Reviews |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/ntrev-2023-0572 |
| _version_ | 1797768171708481536 |
|---|---|
| author | Fan Shiqi Talha Mohd Yu Xia Lei Haoyuan Tan Yi Zhang Hui Lin Yuanhua Zhou Changchun Fan Yujiang |
| author_facet | Fan Shiqi Talha Mohd Yu Xia Lei Haoyuan Tan Yi Zhang Hui Lin Yuanhua Zhou Changchun Fan Yujiang |
| author_sort | Fan Shiqi |
| collection | DOAJ |
| description | Porous structures and surface morphology of bone tissue scaffolds play an important role in improving the biocompatibility and antibacterial properties for bone repair. In this study, we investigated the effect of different anodic oxidation parameters on the nanotubes morphology in 3D printed porous titanium scaffolds. Micron-scale pores were fabricated by 3D printing first, and then the nano-scale tubes were obtained via anodizing treatments. The results demonstrated that the morphology of the nanotubes depended on the anodic oxidation time and voltage, respectively. Longer anodic oxidation led to the formation of circle-like nanotubes, and the diameter of the nanotubes increased with the voltage. The scaffolds anodized at 30 V showed the best cell proliferation potential. The presence of nanotubes on the surface of scaffold altered the adhesion of bacteria so that it improved the antibacterial properties of scaffold. The formation of nanotubes improved the drug-loading ability of the scaffold, which are used for loading of minocycline antibacterial drugs. The proposed 3D printed porous Ti6Al4V scaffold with nanotubes surface modification showed obvious antibacterial effect, which is expected to have a promising application in antibacterial bone prosthesis. |
| first_indexed | 2024-03-12T20:50:40Z |
| format | Article |
| id | doaj.art-efc670fdc561443bb5c78ffd2de7a6f0 |
| institution | Directory Open Access Journal |
| issn | 2191-9097 |
| language | English |
| last_indexed | 2024-03-12T20:50:40Z |
| publishDate | 2023-07-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Nanotechnology Reviews |
| spelling | doaj.art-efc670fdc561443bb5c78ffd2de7a6f02023-08-01T05:15:29ZengDe GruyterNanotechnology Reviews2191-90972023-07-0112159361910.1515/ntrev-2023-05723D printing of porous Ti6Al4V bone tissue engineering scaffold and surface anodization preparation of nanotubes to enhance its biological propertyFan Shiqi0Talha Mohd1Yu Xia2Lei Haoyuan3Tan Yi4Zhang Hui5Lin Yuanhua6Zhou Changchun7Fan Yujiang8School of New Energy and Materials, Southwest Petroleum University, Chengdu, 610500, ChinaSchool of New Energy and Materials, Southwest Petroleum University, Chengdu, 610500, ChinaDepartment of Clinical Laboratory, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, ChinaCollege of Biomedical Engineering, National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, ChinaState Key Laboratory of Oral Disease, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, ChinaState Key Laboratory of Oral Disease, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, ChinaSchool of New Energy and Materials, Southwest Petroleum University, Chengdu, 610500, ChinaCollege of Biomedical Engineering, National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, ChinaCollege of Biomedical Engineering, National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, ChinaPorous structures and surface morphology of bone tissue scaffolds play an important role in improving the biocompatibility and antibacterial properties for bone repair. In this study, we investigated the effect of different anodic oxidation parameters on the nanotubes morphology in 3D printed porous titanium scaffolds. Micron-scale pores were fabricated by 3D printing first, and then the nano-scale tubes were obtained via anodizing treatments. The results demonstrated that the morphology of the nanotubes depended on the anodic oxidation time and voltage, respectively. Longer anodic oxidation led to the formation of circle-like nanotubes, and the diameter of the nanotubes increased with the voltage. The scaffolds anodized at 30 V showed the best cell proliferation potential. The presence of nanotubes on the surface of scaffold altered the adhesion of bacteria so that it improved the antibacterial properties of scaffold. The formation of nanotubes improved the drug-loading ability of the scaffold, which are used for loading of minocycline antibacterial drugs. The proposed 3D printed porous Ti6Al4V scaffold with nanotubes surface modification showed obvious antibacterial effect, which is expected to have a promising application in antibacterial bone prosthesis.https://doi.org/10.1515/ntrev-2023-05723d printingti6al4v scaffoldnanotubes |
| spellingShingle | Fan Shiqi Talha Mohd Yu Xia Lei Haoyuan Tan Yi Zhang Hui Lin Yuanhua Zhou Changchun Fan Yujiang 3D printing of porous Ti6Al4V bone tissue engineering scaffold and surface anodization preparation of nanotubes to enhance its biological property Nanotechnology Reviews 3d printing ti6al4v scaffold nanotubes |
| title | 3D printing of porous Ti6Al4V bone tissue engineering scaffold and surface anodization preparation of nanotubes to enhance its biological property |
| title_full | 3D printing of porous Ti6Al4V bone tissue engineering scaffold and surface anodization preparation of nanotubes to enhance its biological property |
| title_fullStr | 3D printing of porous Ti6Al4V bone tissue engineering scaffold and surface anodization preparation of nanotubes to enhance its biological property |
| title_full_unstemmed | 3D printing of porous Ti6Al4V bone tissue engineering scaffold and surface anodization preparation of nanotubes to enhance its biological property |
| title_short | 3D printing of porous Ti6Al4V bone tissue engineering scaffold and surface anodization preparation of nanotubes to enhance its biological property |
| title_sort | 3d printing of porous ti6al4v bone tissue engineering scaffold and surface anodization preparation of nanotubes to enhance its biological property |
| topic | 3d printing ti6al4v scaffold nanotubes |
| url | https://doi.org/10.1515/ntrev-2023-0572 |
| work_keys_str_mv | AT fanshiqi 3dprintingofporousti6al4vbonetissueengineeringscaffoldandsurfaceanodizationpreparationofnanotubestoenhanceitsbiologicalproperty AT talhamohd 3dprintingofporousti6al4vbonetissueengineeringscaffoldandsurfaceanodizationpreparationofnanotubestoenhanceitsbiologicalproperty AT yuxia 3dprintingofporousti6al4vbonetissueengineeringscaffoldandsurfaceanodizationpreparationofnanotubestoenhanceitsbiologicalproperty AT leihaoyuan 3dprintingofporousti6al4vbonetissueengineeringscaffoldandsurfaceanodizationpreparationofnanotubestoenhanceitsbiologicalproperty AT tanyi 3dprintingofporousti6al4vbonetissueengineeringscaffoldandsurfaceanodizationpreparationofnanotubestoenhanceitsbiologicalproperty AT zhanghui 3dprintingofporousti6al4vbonetissueengineeringscaffoldandsurfaceanodizationpreparationofnanotubestoenhanceitsbiologicalproperty AT linyuanhua 3dprintingofporousti6al4vbonetissueengineeringscaffoldandsurfaceanodizationpreparationofnanotubestoenhanceitsbiologicalproperty AT zhouchangchun 3dprintingofporousti6al4vbonetissueengineeringscaffoldandsurfaceanodizationpreparationofnanotubestoenhanceitsbiologicalproperty AT fanyujiang 3dprintingofporousti6al4vbonetissueengineeringscaffoldandsurfaceanodizationpreparationofnanotubestoenhanceitsbiologicalproperty |