Chronic hyperglycemia induces trans-differentiation of human pancreatic stellate cells and enhances the malignant molecular communication with human pancreatic cancer cells.

Chronic hyperglycemia induces trans-differentiation of human pancreatic stellate cells and enhances the malignant molecular communication with human pancreatic cancer cells.

Diabetes mellitus is linked to pancreatic cancer. We hypothesized a role for pancreatic stellate cells (PSC) in the hyperglycemia induced deterioration of pancreatic cancer and therefore studied two human cell lines (RLT-PSC, T3M4) in hyperglycemic environment.The effect of chronic hyperglycemia (CH...

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Main Authors: Katalin Kiss, Kornélia Baghy, Sándor Spisák, Szilárd Szanyi, Zsolt Tulassay, Attila Zalatnai, J-Matthias Löhr, Ralf Jesenofsky, Ilona Kovalszky, Gábor Firneisz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4444240?pdf=render

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