Ramadan Intermittent Fasting Is Associated with Changes in Circulating Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Metabolically Healthy Obese Subjects
<i>Background and Objectives:</i> Dietary modification is the principal approach to the management of hyperlipidemia in adults. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of plasma cholesterol and a target for novel lipid-lowering pharmacotherapies. This stu...
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| Format: | Article |
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MDPI AG
2022-03-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/4/503 |
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| author | Hayder Hasan Mohamed Madkour Samir Awadallah Mohamed Hassanein Haitham Jahrami MoezAlIslam Faris |
| author_facet | Hayder Hasan Mohamed Madkour Samir Awadallah Mohamed Hassanein Haitham Jahrami MoezAlIslam Faris |
| author_sort | Hayder Hasan |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> Dietary modification is the principal approach to the management of hyperlipidemia in adults. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of plasma cholesterol and a target for novel lipid-lowering pharmacotherapies. This study aimed to explore how circulating levels of PCSK9 changed during Ramadan intermittent fasting in metabolically healthy obese subjects. <i>Materials and Methods</i>: This cross-sectional study used convenience sampling to recruit 55 overweight and obese participants (22 females and 33 males) who observed Ramadan fasting. Body weight and composition, glucoregulatory factors, serum PCSK9 concentration, dietary intake, and physical activity were assessed 1 week before and at the end of Ramadan fasting. <i>Results:</i> The median (interquartile range) age was 35 (22) years, and body mass index was 30.2 (5.4). We found significant (<i>p</i> < 0.05) increases in serum levels of PCSK9, serum insulin, insulin resistance, and leptin at the end of Ramadan compared with pre-fasting levels. Significant (<i>p</i> < 0.05) reductions in body weight, waist circumference, systolic and diastolic blood pressure, total cholesterol, triglycerides, high-density lipoprotein cholesterol, and adiponectin were also observed at the end of Ramadan. <i>Conclusions:</i> Observing Ramadan fasting was associated with increased PCSK9 levels in metabolically healthy obese subjects. The complex relationships between PCSK9 and insulin resistance and dysregulation of adipokine secretion in relation to dietary and lifestyle modifications during Ramadan warrant further research. |
| first_indexed | 2024-03-09T04:26:22Z |
| format | Article |
| id | doaj.art-efc8f33cca3a48539d875f68b3a07f08 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T04:26:22Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-efc8f33cca3a48539d875f68b3a07f082023-12-03T13:41:09ZengMDPI AGMedicina1010-660X1648-91442022-03-0158450310.3390/medicina58040503Ramadan Intermittent Fasting Is Associated with Changes in Circulating Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Metabolically Healthy Obese SubjectsHayder Hasan0Mohamed Madkour1Samir Awadallah2Mohamed Hassanein3Haitham Jahrami4MoezAlIslam Faris5Department of Clinical Nutrition and Dietetics, College of Health Sciences/Research Institute for Medical and Health Sciences (RIMHS), University of Sharjah, Sharjah P.O. Box 27272, United Arab EmiratesDepartment of Medical Laboratory Sciences, College of Health Sciences/Research Institute for Medical and Health Sciences (RIMHS), University of Sharjah, Sharjah P.O. Box 27272, United Arab EmiratesDepartment of Medical Laboratory Sciences, College of Health Sciences/Research Institute for Medical and Health Sciences (RIMHS), University of Sharjah, Sharjah P.O. Box 27272, United Arab EmiratesEndocrine Department, Dubai Hospital, Dubai Health Authority, Dubai P.O. Box 7272, United Arab EmiratesCollege of Medicine and Medical Sciences, Arabian Gulf University, Manama P.O. Box 26671, BahrainDepartment of Clinical Nutrition and Dietetics, College of Health Sciences/Research Institute for Medical and Health Sciences (RIMHS), University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates<i>Background and Objectives:</i> Dietary modification is the principal approach to the management of hyperlipidemia in adults. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of plasma cholesterol and a target for novel lipid-lowering pharmacotherapies. This study aimed to explore how circulating levels of PCSK9 changed during Ramadan intermittent fasting in metabolically healthy obese subjects. <i>Materials and Methods</i>: This cross-sectional study used convenience sampling to recruit 55 overweight and obese participants (22 females and 33 males) who observed Ramadan fasting. Body weight and composition, glucoregulatory factors, serum PCSK9 concentration, dietary intake, and physical activity were assessed 1 week before and at the end of Ramadan fasting. <i>Results:</i> The median (interquartile range) age was 35 (22) years, and body mass index was 30.2 (5.4). We found significant (<i>p</i> < 0.05) increases in serum levels of PCSK9, serum insulin, insulin resistance, and leptin at the end of Ramadan compared with pre-fasting levels. Significant (<i>p</i> < 0.05) reductions in body weight, waist circumference, systolic and diastolic blood pressure, total cholesterol, triglycerides, high-density lipoprotein cholesterol, and adiponectin were also observed at the end of Ramadan. <i>Conclusions:</i> Observing Ramadan fasting was associated with increased PCSK9 levels in metabolically healthy obese subjects. The complex relationships between PCSK9 and insulin resistance and dysregulation of adipokine secretion in relation to dietary and lifestyle modifications during Ramadan warrant further research.https://www.mdpi.com/1648-9144/58/4/503blood lipidscaloric restrictioncardiometabolic risk factorsintermittent fastinglipid metabolismobesity |
| spellingShingle | Hayder Hasan Mohamed Madkour Samir Awadallah Mohamed Hassanein Haitham Jahrami MoezAlIslam Faris Ramadan Intermittent Fasting Is Associated with Changes in Circulating Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Metabolically Healthy Obese Subjects Medicina blood lipids caloric restriction cardiometabolic risk factors intermittent fasting lipid metabolism obesity |
| title | Ramadan Intermittent Fasting Is Associated with Changes in Circulating Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Metabolically Healthy Obese Subjects |
| title_full | Ramadan Intermittent Fasting Is Associated with Changes in Circulating Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Metabolically Healthy Obese Subjects |
| title_fullStr | Ramadan Intermittent Fasting Is Associated with Changes in Circulating Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Metabolically Healthy Obese Subjects |
| title_full_unstemmed | Ramadan Intermittent Fasting Is Associated with Changes in Circulating Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Metabolically Healthy Obese Subjects |
| title_short | Ramadan Intermittent Fasting Is Associated with Changes in Circulating Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Metabolically Healthy Obese Subjects |
| title_sort | ramadan intermittent fasting is associated with changes in circulating proprotein convertase subtilisin kexin type 9 pcsk9 in metabolically healthy obese subjects |
| topic | blood lipids caloric restriction cardiometabolic risk factors intermittent fasting lipid metabolism obesity |
| url | https://www.mdpi.com/1648-9144/58/4/503 |
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