High-Throughput Sequencing is a Crucial Tool to Investigate the Contribution of Human Endogenous Retroviruses (HERVs) to Human Biology and Development
Human Endogenous retroviruses (HERVs) are remnants of ancient retroviral infections that represent a large fraction of our genome. Their transcriptional activity is finely regulated in early developmental stages and their expression is modulated in different cell types and tissues. Such activity has...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/12/6/633 |
| _version_ | 1797565607078526976 |
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| author | Maria Paola Pisano Nicole Grandi Enzo Tramontano |
| author_facet | Maria Paola Pisano Nicole Grandi Enzo Tramontano |
| author_sort | Maria Paola Pisano |
| collection | DOAJ |
| description | Human Endogenous retroviruses (HERVs) are remnants of ancient retroviral infections that represent a large fraction of our genome. Their transcriptional activity is finely regulated in early developmental stages and their expression is modulated in different cell types and tissues. Such activity has an impact on human physiology and pathology that is only partially understood up to date. Novel high-throughput sequencing tools have recently allowed for a great advancement in elucidating the various HERV expression patterns in different tissues as well as the mechanisms controlling their transcription, and overall, have helped in gaining better insights in an all-inclusive understanding of the impact of HERVs in biology of the host. |
| first_indexed | 2024-03-10T19:14:34Z |
| format | Article |
| id | doaj.art-efcc0a60645b4e2caea1c573d0b4fd37 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T19:14:34Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-efcc0a60645b4e2caea1c573d0b4fd372023-11-20T03:31:12ZengMDPI AGViruses1999-49152020-06-0112663310.3390/v12060633High-Throughput Sequencing is a Crucial Tool to Investigate the Contribution of Human Endogenous Retroviruses (HERVs) to Human Biology and DevelopmentMaria Paola Pisano0Nicole Grandi1Enzo Tramontano2Laboratory of Molecular Virology, Department of Life and Environmental Sciences, University of Cagliari, 09042 Cagliari, ItalyLaboratory of Molecular Virology, Department of Life and Environmental Sciences, University of Cagliari, 09042 Cagliari, ItalyLaboratory of Molecular Virology, Department of Life and Environmental Sciences, University of Cagliari, 09042 Cagliari, ItalyHuman Endogenous retroviruses (HERVs) are remnants of ancient retroviral infections that represent a large fraction of our genome. Their transcriptional activity is finely regulated in early developmental stages and their expression is modulated in different cell types and tissues. Such activity has an impact on human physiology and pathology that is only partially understood up to date. Novel high-throughput sequencing tools have recently allowed for a great advancement in elucidating the various HERV expression patterns in different tissues as well as the mechanisms controlling their transcription, and overall, have helped in gaining better insights in an all-inclusive understanding of the impact of HERVs in biology of the host.https://www.mdpi.com/1999-4915/12/6/633HERVshuman genomehigh-throughput sequencingexpression |
| spellingShingle | Maria Paola Pisano Nicole Grandi Enzo Tramontano High-Throughput Sequencing is a Crucial Tool to Investigate the Contribution of Human Endogenous Retroviruses (HERVs) to Human Biology and Development Viruses HERVs human genome high-throughput sequencing expression |
| title | High-Throughput Sequencing is a Crucial Tool to Investigate the Contribution of Human Endogenous Retroviruses (HERVs) to Human Biology and Development |
| title_full | High-Throughput Sequencing is a Crucial Tool to Investigate the Contribution of Human Endogenous Retroviruses (HERVs) to Human Biology and Development |
| title_fullStr | High-Throughput Sequencing is a Crucial Tool to Investigate the Contribution of Human Endogenous Retroviruses (HERVs) to Human Biology and Development |
| title_full_unstemmed | High-Throughput Sequencing is a Crucial Tool to Investigate the Contribution of Human Endogenous Retroviruses (HERVs) to Human Biology and Development |
| title_short | High-Throughput Sequencing is a Crucial Tool to Investigate the Contribution of Human Endogenous Retroviruses (HERVs) to Human Biology and Development |
| title_sort | high throughput sequencing is a crucial tool to investigate the contribution of human endogenous retroviruses hervs to human biology and development |
| topic | HERVs human genome high-throughput sequencing expression |
| url | https://www.mdpi.com/1999-4915/12/6/633 |
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