Analysis of the risk factors for allograft vasculopathy in asymptomatic patients after cardiac transplantation
OBJECTIVE: To study the influence of immune and nonimmune risk factors on the development of allograft vasculopathy after cardiac transplantation. METHODS: We studied 39 patients with a mean age of 46±12 years. The following variables were analyzed: weight (kg), body mass index (kg/m²), donor's...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Cardiologia (SBC)
2000-11-01
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| Series: | Arquivos Brasileiros de Cardiologia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2000001100006 |
| _version_ | 1828365745175658496 |
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| author | Fernando Bacal Viviane Cordeiro Veiga Alfredo Inácio Fiorelli Giovanni Bellotti Edimar Alcides Bocchi Noedir Antonio Groppo Stolf José Antonio Franchini Ramires |
| author_facet | Fernando Bacal Viviane Cordeiro Veiga Alfredo Inácio Fiorelli Giovanni Bellotti Edimar Alcides Bocchi Noedir Antonio Groppo Stolf José Antonio Franchini Ramires |
| author_sort | Fernando Bacal |
| collection | DOAJ |
| description | OBJECTIVE: To study the influence of immune and nonimmune risk factors on the development of allograft vasculopathy after cardiac transplantation. METHODS: We studied 39 patients with a mean age of 46±12 years. The following variables were analyzed: weight (kg), body mass index (kg/m²), donor's age and sex, rejection episodes in the first and second years after transplantation, systolic and diastolic blood pressures (mmHg), total cholesterol and fractions (mg/dL), triglycerides (mg/dL), diabetes, and cytomegalovirus infection. The presence of allograft vasculopathy was established through coronary angiography. RESULTS: Allograft vasculopathy was observed in 15 (38%) patients. No statistically significant difference was observed between the two groups in regard to hypertension, cytomegalovirus infection, diabetes, donor's sex and age, rejection episodes in the first and second years after transplantation, and cholesterol levels. We observed a tendency toward higher levels of triglycerides in the group with disease. Univariate and multivariate analyses showed statistically significant differences between the two groups when we analyzed the body mass index (24.53±4.3 versus 28.11±4.6; p=0.019). CONCLUSION: Body mass index was an important marker of allograft vasculopathy in the population studied. |
| first_indexed | 2024-04-14T05:36:08Z |
| format | Article |
| id | doaj.art-efcca3a5393b405a8a2be4adb52fca13 |
| institution | Directory Open Access Journal |
| issn | 0066-782X 1678-4170 |
| language | English |
| last_indexed | 2024-04-14T05:36:08Z |
| publishDate | 2000-11-01 |
| publisher | Sociedade Brasileira de Cardiologia (SBC) |
| record_format | Article |
| series | Arquivos Brasileiros de Cardiologia |
| spelling | doaj.art-efcca3a5393b405a8a2be4adb52fca132022-12-22T02:09:39ZengSociedade Brasileira de Cardiologia (SBC)Arquivos Brasileiros de Cardiologia0066-782X1678-41702000-11-0175542142810.1590/S0066-782X2000001100006Analysis of the risk factors for allograft vasculopathy in asymptomatic patients after cardiac transplantationFernando BacalViviane Cordeiro VeigaAlfredo Inácio FiorelliGiovanni BellottiEdimar Alcides BocchiNoedir Antonio Groppo StolfJosé Antonio Franchini RamiresOBJECTIVE: To study the influence of immune and nonimmune risk factors on the development of allograft vasculopathy after cardiac transplantation. METHODS: We studied 39 patients with a mean age of 46±12 years. The following variables were analyzed: weight (kg), body mass index (kg/m²), donor's age and sex, rejection episodes in the first and second years after transplantation, systolic and diastolic blood pressures (mmHg), total cholesterol and fractions (mg/dL), triglycerides (mg/dL), diabetes, and cytomegalovirus infection. The presence of allograft vasculopathy was established through coronary angiography. RESULTS: Allograft vasculopathy was observed in 15 (38%) patients. No statistically significant difference was observed between the two groups in regard to hypertension, cytomegalovirus infection, diabetes, donor's sex and age, rejection episodes in the first and second years after transplantation, and cholesterol levels. We observed a tendency toward higher levels of triglycerides in the group with disease. Univariate and multivariate analyses showed statistically significant differences between the two groups when we analyzed the body mass index (24.53±4.3 versus 28.11±4.6; p=0.019). CONCLUSION: Body mass index was an important marker of allograft vasculopathy in the population studied.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2000001100006cardiac transplantationallograft vasculopathyrisk factorsbody mass index |
| spellingShingle | Fernando Bacal Viviane Cordeiro Veiga Alfredo Inácio Fiorelli Giovanni Bellotti Edimar Alcides Bocchi Noedir Antonio Groppo Stolf José Antonio Franchini Ramires Analysis of the risk factors for allograft vasculopathy in asymptomatic patients after cardiac transplantation Arquivos Brasileiros de Cardiologia cardiac transplantation allograft vasculopathy risk factors body mass index |
| title | Analysis of the risk factors for allograft vasculopathy in asymptomatic patients after cardiac transplantation |
| title_full | Analysis of the risk factors for allograft vasculopathy in asymptomatic patients after cardiac transplantation |
| title_fullStr | Analysis of the risk factors for allograft vasculopathy in asymptomatic patients after cardiac transplantation |
| title_full_unstemmed | Analysis of the risk factors for allograft vasculopathy in asymptomatic patients after cardiac transplantation |
| title_short | Analysis of the risk factors for allograft vasculopathy in asymptomatic patients after cardiac transplantation |
| title_sort | analysis of the risk factors for allograft vasculopathy in asymptomatic patients after cardiac transplantation |
| topic | cardiac transplantation allograft vasculopathy risk factors body mass index |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2000001100006 |
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