INTERACTION OF VESICULAR MONOAMINE TRANSPORTER 2 (VMAT2) AND NEUROMELANIN PIGMENT AMONG THE MIDBRAIN DOPAMINERGIC NEURONS, IN MAN

INTERACTION OF VESICULAR MONOAMINE TRANSPORTER 2 (VMAT2) AND NEUROMELANIN PIGMENT AMONG THE MIDBRAIN DOPAMINERGIC NEURONS, IN MAN

Neuromelanin (NM) pigment accumulates with age in catecholaminergic neurons in man, and the ventral substantia nigra dopaminergic neurons that are the most vulnerable to degeneration in Parkinson's disease (PD) contain the greatest amount of this pigment. In vitro data indicate that NM pigm...

Full description

Bibliographic Details
Main Authors:	P. Pasbakhsh, D.C. German N. Omidi
Format:	Article
Language:	English
Published:	Tehran University of Medical Sciences 2004-05-01
Series:	Acta Medica Iranica
Subjects:	Substantia nigra tyrosine hydroxylase locus coeruleus
Online Access:	http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/345.pdf&manuscript_id=345

Similar Items

Selective Knockout of the Vesicular Monoamine Transporter 2 (Vmat2) Gene in Calbindin2/Calretinin-Positive Neurons Results in Profound Changes in Behavior and Response to Drugs of Abuse
by: Niclas König, et al.
Published: (2020-11-01)

An investigation of neuromelanin distribution in substantia nigra and locus coeruleus in patients with Parkinson’s disease using neuromelanin-sensitive MRI
by: Qiang Liu, et al.
Published: (2023-08-01)

Locus coeruleus and substantia nigra neuromelanin magnetic resonance imaging differentiates Parkinson’s disease and essential tremor
by: Xinhui Wang, et al.
Published: (2023-01-01)

Neuromelanin magnetic resonance imaging of substantia nigra and locus coeruleus in Parkinson’s disease with freezing of gait
by: Shangpei Wang, et al.
Published: (2023-02-01)

Interaction of Neuromelanin with Xenobiotics and Consequences for Neurodegeneration; Promising Experimental Models
by: Andrea Capucciati, et al.
Published: (2021-05-01)

The Use of Physiological Signals in Brainstem/Midbrain fMRI
by: Andy Schumann, et al.
Published: (2018-10-01)

Neuromelanin related ultra-high field signal intensity of the locus coeruleus differs between Parkinson’s disease and controls
by: Amée F. Wolters, et al.
Published: (2023-01-01)

Interplay of Ferritin Accumulation and Ferroportin Loss in Ageing Brain: Implication for Protein Aggregation in Down Syndrome Dementia, Alzheimer’s, and Parkinson’s Diseases
by: Animesh Alexander Raha, et al.
Published: (2022-01-01)

Vesicular expression and release of ATP from dopaminergic neurons of the mouse retina and midbrain
by: Tracy eHo, et al.
Published: (2015-10-01)

Effect of D-amphetamine on dopaminergic neurons of substantia nigra and expression of tyrosine hydroxylase in striatum and pre-frontal cortex of D-amphetamine treated Wistar rats
by: Sarun Koirala, et al.
Published: (2014-10-01)

Visualization of dopaminergic midbrain structures in Parkinson’s disease
by: R. R. Bogdanov, et al.
Published: (2017-02-01)

Repeated Methamphetamine Administration Results in Axon Loss Prior to Somatic Loss of Substantia Nigra Pars Compacta and Locus Coeruleus Neurons in Male but Not Female Mice
by: Alexander Pilski, et al.
Published: (2023-08-01)

Application of the Catecholaminergic Neuron Electron Transport (CNET) Physical Substrate for Consciousness and Action Selection to Integrated Information Theory
by: Chris Rourk
Published: (2022-01-01)

The effect of titanium dioxide nanoparticles on mice midbrain substantia nigra
by: Zahra Heidari, et al.
Published: (2019-07-01)

Neonatal exposure to lipopolysaccharide enhances vulnerability of nigrostriatal dopaminergic neurons to rotenone neurotoxicity in later life
by: Lir-Wan Fan, et al.
Published: (2011-12-01)

Tyrosine Hydroxylase, Vesicular Monoamine Transporter and Dopamine Transporter mRNA Expression in Nigrostriatal Tissue of Rats with Pedunculopontine Neurotoxic Lesion
by: Lisette Blanco-Lezcano, et al.
Published: (2018-02-01)

Dopaminergic neurotoxins require excitotoxic stimulation in organotypic cultures
by: Geraldine J. Kress, et al.
Published: (2005-12-01)

Nicotine-Mediated Recruitment of GABAergic Neurons to a Dopaminergic Phenotype Attenuates Motor Deficits in an Alpha-Synuclein Parkinson’s Model
by: Jessica IChi Lai, et al.
Published: (2023-02-01)

Hypoxic-ischemic injury decreases anxiety-like behavior in rats when associated with loss of tyrosine-hydroxylase immunoreactive neurons of the substantia nigra
by: Hei Ming-Yan, et al.
Published: (2012-01-01)

Hypoxic-ischemic injury decreases anxiety-like behavior in rats when associated with loss of tyrosine-hydroxylase immunoreactive neurons of the substantia nigra
by: Hei Ming-Yan, et al.
Published: (2012-01-01)

Diagnosing Parkinson's disease by combining neuromelanin and iron imaging features using an automated midbrain template approach
by: Mojtaba Jokar, et al.
Published: (2023-02-01)

THE ORGANIZATION OF NON-DOPAMINERGIC NIGRAL PROJECTIONS TO THE THALAMIC NUCLEUS OF THE RAT
by: Mehdizadeh M, et al.
Published: (2001-01-01)

Neuromelanin in Parkinson’s Disease: Tyrosine Hydroxylase and Tyrosinase
by: Toshiharu Nagatsu, et al.
Published: (2022-04-01)

Changes in cytoplasmic and extracellular neuromelanin in human substantia nigra with normal aging
by: Dmitrii E. Korzhevskii, et al.
Published: (2021-09-01)

MRI T2 and T2* relaxometry to visualize neuromelanin in the dorsal substantia nigra pars compacta
by: Hansol Lee, et al.
Published: (2020-05-01)

Semi-Automatic Signature-Based Segmentation Method for Quantification of Neuromelanin in Substantia Nigra
by: Gašper Zupan, et al.
Published: (2019-11-01)

Midbrain dopaminergic neurons generate calcium and sodium currents and release dopamine in the striatum of pups
by: Diana Carolina Ferrari, et al.
Published: (2012-03-01)

Rhythmic oscillations in the midbrain dopaminergic nuclei in mice
by: Virginie J. Oberto, et al.
Published: (2023-06-01)

Co-Expression of Nogo-A in Dopaminergic Neurons of the Human Substantia Nigra Pars Compacta Is Reduced in Parkinson’s Disease
by: Gian-Carlo Eyer, et al.
Published: (2021-11-01)

Structural Connectivity-Based Parcellation of the Dopaminergic Midbrain in Healthy Subjects and Schizophrenic Patients
by: Gianpaolo Antonio Basile, et al.
Published: (2020-12-01)

Evidence of functional duplicity of Nestin expression in the adult mouse midbrain
by: Parisa Farzanehfar, et al.
Published: (2017-03-01)

Decreased locus coeruleus signal associated with Alzheimer’s disease based on neuromelanin-sensitive magnetic resonance imaging technique
by: Meng Li, et al.
Published: (2022-10-01)

Dopamine Signaling in Substantia Nigra and Its Impact on Locomotor Function—Not a New Concept, but Neglected Reality
by: Michael F. Salvatore
Published: (2024-01-01)

Lesion of the subthalamic nucleus reverses motor deficits but not death of nigrostriatal dopaminergic neurons in a rat 6-hydroxydopamine-lesion model of Parkinson's disease
by: V. Rizelio, et al.
Published: (2010-01-01)

Dopaminergic nuclei in the chick midbrain express serotonin receptor subfamily genes
by: Toshiyuki Fujita, et al.
Published: (2022-11-01)

Quantitative iron–neuromelanin MRI associates with motor severity in Parkinson's disease and matches radiological disease classification
by: Septian Hartono, et al.
Published: (2023-11-01)

Non-linear developmental trajectory of electrical phenotype in rat substantia nigra pars compacta dopaminergic neurons
by: Martial A Dufour, et al.
Published: (2014-10-01)

Locus coeruleus: A brain region exhibiting neuronal alterations in Parkinson’s disease rat model
by: Samah M. Fathy
Published: (2015-05-01)

Levodopa Improves Behavioral Deficits of Mice with Parkinson's Disease Symptoms via Curbing NLRP3 Inflammasome Activation and Enhancing Tyrosine Hydroxylase Levels in the Striatum and Substantia Nigra
by: Xi Chen, et al.
Published: (2024-01-01)

Peripheral inflammation and neuroprotection: Systemic pretreatment with complete Freund's adjuvant reduces 6-hydroxydopamine toxicity in a rodent model of Parkinson's disease
by: Marie-Thérèse Armentero, et al.
Published: (2006-12-01)