Summary: | A hybrid compound <b>5</b>: (<i>E</i>)-6-hydroxy-2-oxo-2<i>H</i>-chromen-7-yl 3-(4-hydroxy-3-methoxyphenyl)acrylate composed of (<i>E</i>)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid (ferulic acid) <b>1</b> and 6,7-hydroxycoumarin (esculetin) <b>3</b> was prepared in a 61% yield by the esterification reaction of protected ferulic acid <b>2a</b> with esculetin <b>3</b> in the presence of triethylamine in dichloromethane for 3 h, followed by deprotection using 3M HCl. The structure of compound <b>5</b> was confirmed by <sup>1</sup>H, <sup>13</sup>C NMR spectroscopy, mass-spectrometry and elemental analysis.
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