In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury
Non-biodegradable metals such as mercury accumulate in living organisms during life (bioaccumulation) and also within trophic webs (biomagnification) and may reach high concentrations in humans. The contamination of humans by mercury in drinking water and food may be common, in particular in riversi...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2022-07-01
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| Series: | Brazilian Journal of Medical and Biological Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100647&tlng=en |
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| author | L. Cunha L. Bonfim G. Lima R. Silva L. Silva P. Lima V. Oliveira-Bahia J. Freitas R. Burbano C. Rocha |
| author_facet | L. Cunha L. Bonfim G. Lima R. Silva L. Silva P. Lima V. Oliveira-Bahia J. Freitas R. Burbano C. Rocha |
| author_sort | L. Cunha |
| collection | DOAJ |
| description | Non-biodegradable metals such as mercury accumulate in living organisms during life (bioaccumulation) and also within trophic webs (biomagnification) and may reach high concentrations in humans. The contamination of humans by mercury in drinking water and food may be common, in particular in riverside communities that have a diet rich in fish. In vitro studies of human cell lines exposed to the cytotoxic and mutagenic effects of methylmercury have shown that prolactin has potential cytoprotective properties and may act as a co-mitogenic factor and inhibitor of apoptosis. The present in vivo study investigated the protective potential of prolactin against the toxic effects of methylmercury in the mammal Mus musculus. Histological and biochemical analyses, together with biomarker of genotoxicity, were used to verify the protective potential of prolactin in mice exposed to methylmercury. The reduction in kidney and liver tissue damage was not significant. However, results of biochemical and genotoxic analyses were excellent. After prolactin treatment, a significant reduction was observed in biochemical parameters and mutagenic effects of methylmercury. The study results therefore indicated that prolactin has protective effects against the toxicity of methylmercury and allowed us to suggest the continuation of research to propose prolactin in the future, as an alternative to prevent the damage caused by mercury, especially in populations that are more exposed. |
| first_indexed | 2024-04-12T10:19:42Z |
| format | Article |
| id | doaj.art-efcf2adf25ed445b862ca7266b2a6239 |
| institution | Directory Open Access Journal |
| issn | 1414-431X |
| language | English |
| last_indexed | 2024-04-12T10:19:42Z |
| publishDate | 2022-07-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-efcf2adf25ed445b862ca7266b2a62392022-12-22T03:37:08ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X2022-07-015510.1590/1414-431x2022e11976In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercuryL. Cunhahttps://orcid.org/0000-0002-1085-3635L. Bonfimhttps://orcid.org/0000-0001-6542-6641G. Limahttps://orcid.org/0000-0002-9168-2881R. Silvahttps://orcid.org/0000-0002-6056-7880L. Silvahttps://orcid.org/0000-0002-4417-7401P. Limahttps://orcid.org/0000-0002-1068-2813V. Oliveira-Bahiahttps://orcid.org/0000-0002-5439-4223J. Freitashttps://orcid.org/0000-0002-0568-7177R. Burbanohttps://orcid.org/0000-0002-4872-234XC. Rochahttps://orcid.org/0000-0003-3037-1323Non-biodegradable metals such as mercury accumulate in living organisms during life (bioaccumulation) and also within trophic webs (biomagnification) and may reach high concentrations in humans. The contamination of humans by mercury in drinking water and food may be common, in particular in riverside communities that have a diet rich in fish. In vitro studies of human cell lines exposed to the cytotoxic and mutagenic effects of methylmercury have shown that prolactin has potential cytoprotective properties and may act as a co-mitogenic factor and inhibitor of apoptosis. The present in vivo study investigated the protective potential of prolactin against the toxic effects of methylmercury in the mammal Mus musculus. Histological and biochemical analyses, together with biomarker of genotoxicity, were used to verify the protective potential of prolactin in mice exposed to methylmercury. The reduction in kidney and liver tissue damage was not significant. However, results of biochemical and genotoxic analyses were excellent. After prolactin treatment, a significant reduction was observed in biochemical parameters and mutagenic effects of methylmercury. The study results therefore indicated that prolactin has protective effects against the toxicity of methylmercury and allowed us to suggest the continuation of research to propose prolactin in the future, as an alternative to prevent the damage caused by mercury, especially in populations that are more exposed.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100647&tlng=enMercuryProlactinHistological evaluationBiochemical parametersGenotoxicity |
| spellingShingle | L. Cunha L. Bonfim G. Lima R. Silva L. Silva P. Lima V. Oliveira-Bahia J. Freitas R. Burbano C. Rocha In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury Brazilian Journal of Medical and Biological Research Mercury Prolactin Histological evaluation Biochemical parameters Genotoxicity |
| title | In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury |
| title_full | In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury |
| title_fullStr | In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury |
| title_full_unstemmed | In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury |
| title_short | In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury |
| title_sort | in vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury |
| topic | Mercury Prolactin Histological evaluation Biochemical parameters Genotoxicity |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100647&tlng=en |
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