KRAS-related miR-143 expression is associated with lymph node involvement and correlates with outcome in pancreatic adenocarcinoma patients

KRAS-related miR-143 expression is associated with lymph node involvement and correlates with outcome in pancreatic adenocarcinoma patients

IntroductionPancreatic adenocarcinoma (PC) is one of the most lethal malignancies; even after resection the patients’ 5-year disease-free survival (DFS) is lower than 26%. The genetic mutational landscape of PC is dominated by activating KRAS mutations, that have been reported in approximately 90% o...

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Main Authors: Daniele Lavacchi, Simone Polvani, Antonio Taddei, Federico Scolari, Luca Messerini, Enrico Caliman, Luca Moraldi, Alessia Guidolin, Gian Luca Grazi, Andrea Galli, Serena Pillozzi, Lorenzo Antonuzzo
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Oncology
Subjects:
pancreatic cancer
miRNA
KRAS
miR-143
miR-155
miR-206
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1295936/full

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