Endothelial nitric oxide synthase-derived nitric oxide in the regulation of metabolism [version 1; peer review: 3 approved]
Nitric oxide is an endogenously formed gas that acts as a signaling molecule in the human body. The signaling functions of nitric oxide are accomplished through two primer mechanisms: cGMP-mediated phosphorylation and the formation of S-nitrosocysteine on proteins. This review presents and discusses...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2020-10-01
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| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/9-1190/v1 |
| _version_ | 1811324772044242944 |
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| author | Margarita Tenopoulou Paschalis-Thomas Doulias |
| author_facet | Margarita Tenopoulou Paschalis-Thomas Doulias |
| author_sort | Margarita Tenopoulou |
| collection | DOAJ |
| description | Nitric oxide is an endogenously formed gas that acts as a signaling molecule in the human body. The signaling functions of nitric oxide are accomplished through two primer mechanisms: cGMP-mediated phosphorylation and the formation of S-nitrosocysteine on proteins. This review presents and discusses previous and more recent findings documenting that nitric oxide signaling regulates metabolic activity. These discussions primarily focus on endothelial nitric oxide synthase (eNOS) as the source of nitric oxide. |
| first_indexed | 2024-04-13T14:20:18Z |
| format | Article |
| id | doaj.art-efd4a891fbac492593385ca3ad3261cc |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-04-13T14:20:18Z |
| publishDate | 2020-10-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-efd4a891fbac492593385ca3ad3261cc2022-12-22T02:43:30ZengF1000 Research LtdF1000Research2046-14022020-10-01910.12688/f1000research.19998.121951Endothelial nitric oxide synthase-derived nitric oxide in the regulation of metabolism [version 1; peer review: 3 approved]Margarita Tenopoulou0Paschalis-Thomas Doulias1Children's Hospital of Philadelphia Research Institute, 3517 Civic Center Boulevard, Philadelphia, Pennsylvania, 19104-4318, USAChildren's Hospital of Philadelphia Research Institute, 3517 Civic Center Boulevard, Philadelphia, Pennsylvania, 19104-4318, USANitric oxide is an endogenously formed gas that acts as a signaling molecule in the human body. The signaling functions of nitric oxide are accomplished through two primer mechanisms: cGMP-mediated phosphorylation and the formation of S-nitrosocysteine on proteins. This review presents and discusses previous and more recent findings documenting that nitric oxide signaling regulates metabolic activity. These discussions primarily focus on endothelial nitric oxide synthase (eNOS) as the source of nitric oxide.https://f1000research.com/articles/9-1190/v1 |
| spellingShingle | Margarita Tenopoulou Paschalis-Thomas Doulias Endothelial nitric oxide synthase-derived nitric oxide in the regulation of metabolism [version 1; peer review: 3 approved] F1000Research |
| title | Endothelial nitric oxide synthase-derived nitric oxide in the regulation of metabolism [version 1; peer review: 3 approved] |
| title_full | Endothelial nitric oxide synthase-derived nitric oxide in the regulation of metabolism [version 1; peer review: 3 approved] |
| title_fullStr | Endothelial nitric oxide synthase-derived nitric oxide in the regulation of metabolism [version 1; peer review: 3 approved] |
| title_full_unstemmed | Endothelial nitric oxide synthase-derived nitric oxide in the regulation of metabolism [version 1; peer review: 3 approved] |
| title_short | Endothelial nitric oxide synthase-derived nitric oxide in the regulation of metabolism [version 1; peer review: 3 approved] |
| title_sort | endothelial nitric oxide synthase derived nitric oxide in the regulation of metabolism version 1 peer review 3 approved |
| url | https://f1000research.com/articles/9-1190/v1 |
| work_keys_str_mv | AT margaritatenopoulou endothelialnitricoxidesynthasederivednitricoxideintheregulationofmetabolismversion1peerreview3approved AT paschalisthomasdoulias endothelialnitricoxidesynthasederivednitricoxideintheregulationofmetabolismversion1peerreview3approved |