Juglone induces ferroptosis in glioblastoma cells by inhibiting the Nrf2-GPX4 axis through the phosphorylation of p38MAPK

Juglone induces ferroptosis in glioblastoma cells by inhibiting the Nrf2-GPX4 axis through the phosphorylation of p38MAPK

Abstract Background Ferroptosis, a non-apoptotic form of cell death induced by accumulation of free iron ions and lipid peroxidation, its importance for cancer treatment is gradually being recognized. Research on the anti-cancer mechanism of juglone is accumulating. However, the specific mechanism b...

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Bibliographic Details
Main Authors: Fangzhou Guo, Guoyuan Ling, Jianting Qiu, Jicheng Li, Yu Gan, YingYing Yu, Jiamei Tang, Ligen Mo, Haozhe Piao
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Chinese Medicine
Subjects:
Juglone
Glioblastoma
Ferroptosis
p38MAPK
Nrf2
Online Access:https://doi.org/10.1186/s13020-024-00920-2

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