Interaction between the Hepatitis B Virus and Cellular FLIP Variants in Viral Replication and the Innate Immune System
During viral evolution and adaptation, many viruses have utilized host cellular factors and machinery as their partners. HBx, as a multifunctional viral protein encoded by the hepatitis B virus (HBV), promotes HBV replication and greatly contributes to the development of HBV-associated hepatocellula...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/2/373 |
| _version_ | 1827652191549128704 |
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| author | Ah Ram Lee Yong Kwang Park Mehrangiz Dezhbord Kyun-Hwan Kim |
| author_facet | Ah Ram Lee Yong Kwang Park Mehrangiz Dezhbord Kyun-Hwan Kim |
| author_sort | Ah Ram Lee |
| collection | DOAJ |
| description | During viral evolution and adaptation, many viruses have utilized host cellular factors and machinery as their partners. HBx, as a multifunctional viral protein encoded by the hepatitis B virus (HBV), promotes HBV replication and greatly contributes to the development of HBV-associated hepatocellular carcinoma (HCC). HBx interacts with several host factors in order to regulate HBV replication and evolve carcinogenesis. The cellular FADD-like IL-1β-converting enzyme (FLICE)-like inhibitory protein (c-FLIP) is a major factor that functions in a variety of cellular pathways and specifically in apoptosis. It has been shown that the interaction between HBx and c-FLIP determines HBV fate. In this review, we provide a comprehensive and detailed overview of the interplay between c-FLIP and HBV in various environmental circumstances. We describe strategies adapted by HBV to establish its chronic infection. We also summarize the conventional roles of c-FLIP and highlight the functional outcome of the interaction between c-FLIP and HBV or other viruses in viral replication and the innate immune system. |
| first_indexed | 2024-03-09T20:52:05Z |
| format | Article |
| id | doaj.art-efd76ef130bb436ab1cdee3048de109b |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T20:52:05Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-efd76ef130bb436ab1cdee3048de109b2023-11-23T22:31:55ZengMDPI AGViruses1999-49152022-02-0114237310.3390/v14020373Interaction between the Hepatitis B Virus and Cellular FLIP Variants in Viral Replication and the Innate Immune SystemAh Ram Lee0Yong Kwang Park1Mehrangiz Dezhbord2Kyun-Hwan Kim3Department of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon 16419, KoreaDivision of Chronic Viral Diseases, Center for Emerging Virus Research, National Institute of Infectious Disease, National Institute of Health, Cheongju 28159, KoreaDepartment of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon 16419, KoreaDepartment of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon 16419, KoreaDuring viral evolution and adaptation, many viruses have utilized host cellular factors and machinery as their partners. HBx, as a multifunctional viral protein encoded by the hepatitis B virus (HBV), promotes HBV replication and greatly contributes to the development of HBV-associated hepatocellular carcinoma (HCC). HBx interacts with several host factors in order to regulate HBV replication and evolve carcinogenesis. The cellular FADD-like IL-1β-converting enzyme (FLICE)-like inhibitory protein (c-FLIP) is a major factor that functions in a variety of cellular pathways and specifically in apoptosis. It has been shown that the interaction between HBx and c-FLIP determines HBV fate. In this review, we provide a comprehensive and detailed overview of the interplay between c-FLIP and HBV in various environmental circumstances. We describe strategies adapted by HBV to establish its chronic infection. We also summarize the conventional roles of c-FLIP and highlight the functional outcome of the interaction between c-FLIP and HBV or other viruses in viral replication and the innate immune system.https://www.mdpi.com/1999-4915/14/2/373hepatitis B viruscellular FLIP (c-FLIP)viral FLIP (v-FLIP)HBxinnate immune system |
| spellingShingle | Ah Ram Lee Yong Kwang Park Mehrangiz Dezhbord Kyun-Hwan Kim Interaction between the Hepatitis B Virus and Cellular FLIP Variants in Viral Replication and the Innate Immune System Viruses hepatitis B virus cellular FLIP (c-FLIP) viral FLIP (v-FLIP) HBx innate immune system |
| title | Interaction between the Hepatitis B Virus and Cellular FLIP Variants in Viral Replication and the Innate Immune System |
| title_full | Interaction between the Hepatitis B Virus and Cellular FLIP Variants in Viral Replication and the Innate Immune System |
| title_fullStr | Interaction between the Hepatitis B Virus and Cellular FLIP Variants in Viral Replication and the Innate Immune System |
| title_full_unstemmed | Interaction between the Hepatitis B Virus and Cellular FLIP Variants in Viral Replication and the Innate Immune System |
| title_short | Interaction between the Hepatitis B Virus and Cellular FLIP Variants in Viral Replication and the Innate Immune System |
| title_sort | interaction between the hepatitis b virus and cellular flip variants in viral replication and the innate immune system |
| topic | hepatitis B virus cellular FLIP (c-FLIP) viral FLIP (v-FLIP) HBx innate immune system |
| url | https://www.mdpi.com/1999-4915/14/2/373 |
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