Clinical characteristics associated with occurrence and poor prognosis of interstitial lung disease in rheumatoid arthritis
Background/Aims To analyze clinical characteristics of interstitial lung disease (ILD) associated with rheumatoid arthritis (RA), especially in patients with poor prognosis. Methods Seventy-seven RA patients with ILD and 231 age, sex, and disease duration-matched RA patients without ILD were enrolle...
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| Format: | Article |
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The Korean Association of Internal Medicine
2019-03-01
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| Series: | The Korean Journal of Internal Medicine |
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| Online Access: | http://www.kjim.org/upload/pdf/kjim-2016-349.pdf |
| _version_ | 1818355778134736896 |
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| author | Ji Ae Yang Jeong Seok Lee Jin Kyun Park Eun Bong Lee Yeong Wook Song Eun Young Lee |
| author_facet | Ji Ae Yang Jeong Seok Lee Jin Kyun Park Eun Bong Lee Yeong Wook Song Eun Young Lee |
| author_sort | Ji Ae Yang |
| collection | DOAJ |
| description | Background/Aims To analyze clinical characteristics of interstitial lung disease (ILD) associated with rheumatoid arthritis (RA), especially in patients with poor prognosis. Methods Seventy-seven RA patients with ILD and 231 age, sex, and disease duration-matched RA patients without ILD were enrolled in this retrospective study. Epidemiologic, clinical, and laboratory information were obtained through a medical chart review. Logistic regression analysis was used to estimate the risk of mortality in RA patients with ILD. Results Compared to the RA without ILD group, the RA with ILD group had significantly higher titers of rheumatoid factor and the anti-cyclic citrullinated peptide (p = 0.001 for both), higher levels of C-reactive protein (CRP) at the time of RA diagnosis (p = 0.014), and a higher erythrocyte sedimentation rate (p = 0.022) and CRP levels (p < 0.001) throughout the 10-year follow-up period. These patients also received a higher mean daily dose of corticosteroids (p < 0.001). In the subgroup analysis of RA patients with ILD, 28 patients (36.4%) died during follow-up. Multivariate analysis revealed that older age at the time of ILD diagnosis was significantly associated with mortality. Usual interstitial pneumonia (UIP) subtype on high-resolution computed tomography (HRCT) was also suggested as a poor prognostic factor. Conclusions The survival of RA patients with ILD is adversely affected by age at the time of ILD diagnosis. RA-ILD patients diagnosed after age 65 or with a UIP subtype on HRCT may have a poor prognosis. |
| first_indexed | 2024-12-13T19:46:43Z |
| format | Article |
| id | doaj.art-efd9ad41709c4b93a252974234ab3912 |
| institution | Directory Open Access Journal |
| issn | 1226-3303 2005-6648 |
| language | English |
| last_indexed | 2024-12-13T19:46:43Z |
| publishDate | 2019-03-01 |
| publisher | The Korean Association of Internal Medicine |
| record_format | Article |
| series | The Korean Journal of Internal Medicine |
| spelling | doaj.art-efd9ad41709c4b93a252974234ab39122022-12-21T23:33:32ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482019-03-0134243444110.3904/kjim.2016.349169820Clinical characteristics associated with occurrence and poor prognosis of interstitial lung disease in rheumatoid arthritisJi Ae Yang0Jeong Seok Lee1Jin Kyun Park2Eun Bong Lee3Yeong Wook Song4Eun Young Lee5 Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, KoreaBackground/Aims To analyze clinical characteristics of interstitial lung disease (ILD) associated with rheumatoid arthritis (RA), especially in patients with poor prognosis. Methods Seventy-seven RA patients with ILD and 231 age, sex, and disease duration-matched RA patients without ILD were enrolled in this retrospective study. Epidemiologic, clinical, and laboratory information were obtained through a medical chart review. Logistic regression analysis was used to estimate the risk of mortality in RA patients with ILD. Results Compared to the RA without ILD group, the RA with ILD group had significantly higher titers of rheumatoid factor and the anti-cyclic citrullinated peptide (p = 0.001 for both), higher levels of C-reactive protein (CRP) at the time of RA diagnosis (p = 0.014), and a higher erythrocyte sedimentation rate (p = 0.022) and CRP levels (p < 0.001) throughout the 10-year follow-up period. These patients also received a higher mean daily dose of corticosteroids (p < 0.001). In the subgroup analysis of RA patients with ILD, 28 patients (36.4%) died during follow-up. Multivariate analysis revealed that older age at the time of ILD diagnosis was significantly associated with mortality. Usual interstitial pneumonia (UIP) subtype on high-resolution computed tomography (HRCT) was also suggested as a poor prognostic factor. Conclusions The survival of RA patients with ILD is adversely affected by age at the time of ILD diagnosis. RA-ILD patients diagnosed after age 65 or with a UIP subtype on HRCT may have a poor prognosis.http://www.kjim.org/upload/pdf/kjim-2016-349.pdfarthritis, rheumatoidlung diseases, interstitialrheumatoid arthritis-associated interstitial lung disease |
| spellingShingle | Ji Ae Yang Jeong Seok Lee Jin Kyun Park Eun Bong Lee Yeong Wook Song Eun Young Lee Clinical characteristics associated with occurrence and poor prognosis of interstitial lung disease in rheumatoid arthritis The Korean Journal of Internal Medicine arthritis, rheumatoid lung diseases, interstitial rheumatoid arthritis-associated interstitial lung disease |
| title | Clinical characteristics associated with occurrence and poor prognosis of interstitial lung disease in rheumatoid arthritis |
| title_full | Clinical characteristics associated with occurrence and poor prognosis of interstitial lung disease in rheumatoid arthritis |
| title_fullStr | Clinical characteristics associated with occurrence and poor prognosis of interstitial lung disease in rheumatoid arthritis |
| title_full_unstemmed | Clinical characteristics associated with occurrence and poor prognosis of interstitial lung disease in rheumatoid arthritis |
| title_short | Clinical characteristics associated with occurrence and poor prognosis of interstitial lung disease in rheumatoid arthritis |
| title_sort | clinical characteristics associated with occurrence and poor prognosis of interstitial lung disease in rheumatoid arthritis |
| topic | arthritis, rheumatoid lung diseases, interstitial rheumatoid arthritis-associated interstitial lung disease |
| url | http://www.kjim.org/upload/pdf/kjim-2016-349.pdf |
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