Atrial Fibrillation and Risk of Dementia: Epidemiology, Mechanisms, and Effect of Anticoagulation
Atrial fibrillation (AF) is one of the cardiovascular risk factors for dementia. Several longitudinal studies have reported an association between AF and dementia independently of stroke history. Although the mechanisms underlying this association are not fully understood, proposed mechanisms includ...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-01-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2019.00018/full |
| _version_ | 1818778139854110720 |
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| author | Rose Mary Ferreira Lisboa Da Silva Cláudia Madeira Miranda Tong Liu Gary Tse Leonardo Roever |
| author_facet | Rose Mary Ferreira Lisboa Da Silva Cláudia Madeira Miranda Tong Liu Gary Tse Leonardo Roever |
| author_sort | Rose Mary Ferreira Lisboa Da Silva |
| collection | DOAJ |
| description | Atrial fibrillation (AF) is one of the cardiovascular risk factors for dementia. Several longitudinal studies have reported an association between AF and dementia independently of stroke history. Although the mechanisms underlying this association are not fully understood, proposed mechanisms include cerebral hypoperfusion, inflammation, genetic factors, cerebral microbleeds, and recurrent silent cerebral ischemia. Oral anticoagulation can be used to minimize risk of cognitive decline and dementia, given that brain insults can be caused by chronic microemboli or microbleeds. However, controversy on the effects of warfarin and direct oral anticoagulants on this risk exists. This article will address these aspects, with data on the studies already published and a critical view on this subject. |
| first_indexed | 2024-12-18T11:39:59Z |
| format | Article |
| id | doaj.art-efdb481ddaee42d698b248187a077675 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-18T11:39:59Z |
| publishDate | 2019-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-efdb481ddaee42d698b248187a0776752022-12-21T21:09:26ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2019-01-011310.3389/fnins.2019.00018408404Atrial Fibrillation and Risk of Dementia: Epidemiology, Mechanisms, and Effect of AnticoagulationRose Mary Ferreira Lisboa Da Silva0Cláudia Madeira Miranda1Tong Liu2Gary Tse3Leonardo Roever4Department of Internal Medicine, Federal Institute of Minas Gerais, Belo Horizonte, BrazilDepartment of Internal Medicine, Federal Institute of Minas Gerais, Belo Horizonte, BrazilDepartment of Cardiology, Tianjin Cardiovascular Institute, Tianjin Chest Hospital, Tianjin, ChinaDepartment of Medicine and Therapeutics, The University of Hong Kong, Pokfulam, Hong KongDepartment of Clinical Research, Federal University of Uberlandia, Uberlândia, BrazilAtrial fibrillation (AF) is one of the cardiovascular risk factors for dementia. Several longitudinal studies have reported an association between AF and dementia independently of stroke history. Although the mechanisms underlying this association are not fully understood, proposed mechanisms include cerebral hypoperfusion, inflammation, genetic factors, cerebral microbleeds, and recurrent silent cerebral ischemia. Oral anticoagulation can be used to minimize risk of cognitive decline and dementia, given that brain insults can be caused by chronic microemboli or microbleeds. However, controversy on the effects of warfarin and direct oral anticoagulants on this risk exists. This article will address these aspects, with data on the studies already published and a critical view on this subject.https://www.frontiersin.org/article/10.3389/fnins.2019.00018/fullatrial fibrillationdementiacognitionAlzheimer's diseaseanticoagulation therapy |
| spellingShingle | Rose Mary Ferreira Lisboa Da Silva Cláudia Madeira Miranda Tong Liu Gary Tse Leonardo Roever Atrial Fibrillation and Risk of Dementia: Epidemiology, Mechanisms, and Effect of Anticoagulation Frontiers in Neuroscience atrial fibrillation dementia cognition Alzheimer's disease anticoagulation therapy |
| title | Atrial Fibrillation and Risk of Dementia: Epidemiology, Mechanisms, and Effect of Anticoagulation |
| title_full | Atrial Fibrillation and Risk of Dementia: Epidemiology, Mechanisms, and Effect of Anticoagulation |
| title_fullStr | Atrial Fibrillation and Risk of Dementia: Epidemiology, Mechanisms, and Effect of Anticoagulation |
| title_full_unstemmed | Atrial Fibrillation and Risk of Dementia: Epidemiology, Mechanisms, and Effect of Anticoagulation |
| title_short | Atrial Fibrillation and Risk of Dementia: Epidemiology, Mechanisms, and Effect of Anticoagulation |
| title_sort | atrial fibrillation and risk of dementia epidemiology mechanisms and effect of anticoagulation |
| topic | atrial fibrillation dementia cognition Alzheimer's disease anticoagulation therapy |
| url | https://www.frontiersin.org/article/10.3389/fnins.2019.00018/full |
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