Type I regulatory T cells in malaria: of mice and men
Type I regulatory T (Tr1) cells are a population of regulatory CD4+ T cells implicated in the suppression of pathological immune responses across multiple diseases, but a unifying transcriptional signature of Tr1 identity across disease contexts has not been characterized. In this issue of the JCI,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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American Society for Clinical Investigation
2023-01-01
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| Series: | The Journal of Clinical Investigation |
| Online Access: | https://doi.org/10.1172/JCI166019 |
| _version_ | 1797634547191382016 |
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| author | Jason Nideffer Prasanna Jagannathan |
| author_facet | Jason Nideffer Prasanna Jagannathan |
| author_sort | Jason Nideffer |
| collection | DOAJ |
| description | Type I regulatory T (Tr1) cells are a population of regulatory CD4+ T cells implicated in the suppression of pathological immune responses across multiple diseases, but a unifying transcriptional signature of Tr1 identity across disease contexts has not been characterized. In this issue of the JCI, Edward, Ng, and colleagues identified a conserved transcriptional signature that distinguished Tr1 (IL-10+IFN-γ+) from Th1 (IL-10–IFN-γ+) cells in human and mouse malaria. This signature implicated genes encoding inhibitory receptors — including CTLA-4 and LAG-3 — and transcription factors — including cMAF. The authors identified coinhibitory receptor expression that distinguished Tr1 cells from other CD4+ T cell subsets. Furthermore, cMAF — and, to a lesser extent, BLIMP-1 — promoted IL-10 production in human CD4+ T cells. BLIMP-1 also played a role in supporting the expression of inhibitory receptors. These findings describe a few key features that seem to be conserved by Tr1 cells across multiple species, disease contexts, and marker definitions. |
| first_indexed | 2024-03-11T12:09:16Z |
| format | Article |
| id | doaj.art-efdbbf95c8e54407bb3305d4d27c2989 |
| institution | Directory Open Access Journal |
| issn | 1558-8238 |
| language | English |
| last_indexed | 2024-03-11T12:09:16Z |
| publishDate | 2023-01-01 |
| publisher | American Society for Clinical Investigation |
| record_format | Article |
| series | The Journal of Clinical Investigation |
| spelling | doaj.art-efdbbf95c8e54407bb3305d4d27c29892023-11-07T16:19:42ZengAmerican Society for Clinical InvestigationThe Journal of Clinical Investigation1558-82382023-01-011331Type I regulatory T cells in malaria: of mice and menJason NidefferPrasanna JagannathanType I regulatory T (Tr1) cells are a population of regulatory CD4+ T cells implicated in the suppression of pathological immune responses across multiple diseases, but a unifying transcriptional signature of Tr1 identity across disease contexts has not been characterized. In this issue of the JCI, Edward, Ng, and colleagues identified a conserved transcriptional signature that distinguished Tr1 (IL-10+IFN-γ+) from Th1 (IL-10–IFN-γ+) cells in human and mouse malaria. This signature implicated genes encoding inhibitory receptors — including CTLA-4 and LAG-3 — and transcription factors — including cMAF. The authors identified coinhibitory receptor expression that distinguished Tr1 cells from other CD4+ T cell subsets. Furthermore, cMAF — and, to a lesser extent, BLIMP-1 — promoted IL-10 production in human CD4+ T cells. BLIMP-1 also played a role in supporting the expression of inhibitory receptors. These findings describe a few key features that seem to be conserved by Tr1 cells across multiple species, disease contexts, and marker definitions.https://doi.org/10.1172/JCI166019 |
| spellingShingle | Jason Nideffer Prasanna Jagannathan Type I regulatory T cells in malaria: of mice and men The Journal of Clinical Investigation |
| title | Type I regulatory T cells in malaria: of mice and men |
| title_full | Type I regulatory T cells in malaria: of mice and men |
| title_fullStr | Type I regulatory T cells in malaria: of mice and men |
| title_full_unstemmed | Type I regulatory T cells in malaria: of mice and men |
| title_short | Type I regulatory T cells in malaria: of mice and men |
| title_sort | type i regulatory t cells in malaria of mice and men |
| url | https://doi.org/10.1172/JCI166019 |
| work_keys_str_mv | AT jasonnideffer typeiregulatorytcellsinmalariaofmiceandmen AT prasannajagannathan typeiregulatorytcellsinmalariaofmiceandmen |