Characteristics of culprit intracranial plaque without substantial stenosis in ischemic stroke using three-dimensional high-resolution vessel wall magnetic resonance imaging
Background and aimsWe aim to analyze the difference in quantitative features between culprit and non-culprit intracranial plaque without substantial stenosis using three-dimensional high-resolution vessel wall MRI (3D hr-vw-MRI).MethodsThe patients with cerebral ischemic symptoms of the unilateral a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1160018/full |
| _version_ | 1797862147973185536 |
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| author | Xia Tian Zhang Shi Zhen Wang Bing Xu Wen-Jia Peng Xue-Feng Zhang Qi Liu Shi-Yue Chen Bing Tian Jian-Ping Lu Cheng-Wei Shao |
| author_facet | Xia Tian Zhang Shi Zhen Wang Bing Xu Wen-Jia Peng Xue-Feng Zhang Qi Liu Shi-Yue Chen Bing Tian Jian-Ping Lu Cheng-Wei Shao |
| author_sort | Xia Tian |
| collection | DOAJ |
| description | Background and aimsWe aim to analyze the difference in quantitative features between culprit and non-culprit intracranial plaque without substantial stenosis using three-dimensional high-resolution vessel wall MRI (3D hr-vw-MRI).MethodsThe patients with cerebral ischemic symptoms of the unilateral anterior circulation were recruited who had non-stenotic intracranial atherosclerosis (<50%) confirmed by computed tomographic angiographic (CTA) or magnetic resonance angiography (MRA). All patients underwent 3D hr-vw MRI within 1 month after symptom onset. 3D hr-vw-MRI characteristics, including wall thickness, plaque burden, enhancement ratio, plaque volume and intraplaque hemorrhage, and histogram features were analyzed based on T2-, precontrast T1-, and post-contrast T1-weighted images. Univariate and multivariate logistic regression analysis were used to identify key determinates differentiating culprit and non-culprit plaques and to calculate the odds ratios (ORs) with 95% confidence intervals (CIs).ResultsA total of 150 plaques were identified, of which 133 plaques (97 culprit and 36 non-culprit) were in the middle cerebral artery, three plaques (all culprit) were in the anterior cerebral artery (ACA) and 14 (11 culprit and three non-culprit) were in the internal carotid artery (ICA). Of all the quantitative parameters analyzed, plaque volume, maximum wall thickness, minimum wall thickness, plaque burden, enhancement ratio, coefficient of variation of the most stenotic site, enhancement ratio of whole culprit plaque in culprit plaques were significantly higher than those in non-culprit plaques. Multivariate logistic regression analysis found that plaque volume [OR, 1.527 (95% CI, 1.231–1.894); P < 0.001] and enhancement ratio of whole plaque [OR, 1.095 (95% CI, 1.021–1.175); P = 0.011] were significantly associated with culprit plaque. The combination of the two features obtained a better diagnostic efficacy for culprit plaque with sensitivity and specificity (0.910 and 0.897, respectively) than each of the two parameters alone.Conclusion3D hr-vw MRI features of intracranial atherosclerotic plaques provided potential values over prediction of ischemic stroke patients with non-stenotic arteries. The plaque volume and enhancement ratio of whole plaque of stenosis site were found to be effective predictive parameters. |
| first_indexed | 2024-04-09T22:14:35Z |
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| id | doaj.art-efde9426b4d44c6f80e0434402499246 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-09T22:14:35Z |
| publishDate | 2023-03-01 |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-efde9426b4d44c6f80e04344024992462023-03-23T04:49:39ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-03-011710.3389/fnins.2023.11600181160018Characteristics of culprit intracranial plaque without substantial stenosis in ischemic stroke using three-dimensional high-resolution vessel wall magnetic resonance imagingXia Tian0Zhang Shi1Zhen Wang2Bing Xu3Wen-Jia Peng4Xue-Feng Zhang5Qi Liu6Shi-Yue Chen7Bing Tian8Jian-Ping Lu9Cheng-Wei Shao10Department of Radiology, Changhai Hospital, Naval Medical University, Shanghai, ChinaDepartment of Radiology, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Radiology, Changhai Hospital, Naval Medical University, Shanghai, ChinaDepartment of Radiology, Changhai Hospital, Naval Medical University, Shanghai, ChinaDepartment of Radiology, Changhai Hospital, Naval Medical University, Shanghai, ChinaDepartment of Radiology, Changhai Hospital, Naval Medical University, Shanghai, ChinaDepartment of Radiology, Changhai Hospital, Naval Medical University, Shanghai, ChinaDepartment of Radiology, Changhai Hospital, Naval Medical University, Shanghai, ChinaDepartment of Radiology, Changhai Hospital, Naval Medical University, Shanghai, ChinaDepartment of Radiology, Changhai Hospital, Naval Medical University, Shanghai, ChinaDepartment of Radiology, Changhai Hospital, Naval Medical University, Shanghai, ChinaBackground and aimsWe aim to analyze the difference in quantitative features between culprit and non-culprit intracranial plaque without substantial stenosis using three-dimensional high-resolution vessel wall MRI (3D hr-vw-MRI).MethodsThe patients with cerebral ischemic symptoms of the unilateral anterior circulation were recruited who had non-stenotic intracranial atherosclerosis (<50%) confirmed by computed tomographic angiographic (CTA) or magnetic resonance angiography (MRA). All patients underwent 3D hr-vw MRI within 1 month after symptom onset. 3D hr-vw-MRI characteristics, including wall thickness, plaque burden, enhancement ratio, plaque volume and intraplaque hemorrhage, and histogram features were analyzed based on T2-, precontrast T1-, and post-contrast T1-weighted images. Univariate and multivariate logistic regression analysis were used to identify key determinates differentiating culprit and non-culprit plaques and to calculate the odds ratios (ORs) with 95% confidence intervals (CIs).ResultsA total of 150 plaques were identified, of which 133 plaques (97 culprit and 36 non-culprit) were in the middle cerebral artery, three plaques (all culprit) were in the anterior cerebral artery (ACA) and 14 (11 culprit and three non-culprit) were in the internal carotid artery (ICA). Of all the quantitative parameters analyzed, plaque volume, maximum wall thickness, minimum wall thickness, plaque burden, enhancement ratio, coefficient of variation of the most stenotic site, enhancement ratio of whole culprit plaque in culprit plaques were significantly higher than those in non-culprit plaques. Multivariate logistic regression analysis found that plaque volume [OR, 1.527 (95% CI, 1.231–1.894); P < 0.001] and enhancement ratio of whole plaque [OR, 1.095 (95% CI, 1.021–1.175); P = 0.011] were significantly associated with culprit plaque. The combination of the two features obtained a better diagnostic efficacy for culprit plaque with sensitivity and specificity (0.910 and 0.897, respectively) than each of the two parameters alone.Conclusion3D hr-vw MRI features of intracranial atherosclerotic plaques provided potential values over prediction of ischemic stroke patients with non-stenotic arteries. The plaque volume and enhancement ratio of whole plaque of stenosis site were found to be effective predictive parameters.https://www.frontiersin.org/articles/10.3389/fnins.2023.1160018/full3D high-resolution magnetic resonance imagingintracranial non-stenotic atherosclerotic plaquesischemic strokehistogram featuresdiagnostic efficacy |
| spellingShingle | Xia Tian Zhang Shi Zhen Wang Bing Xu Wen-Jia Peng Xue-Feng Zhang Qi Liu Shi-Yue Chen Bing Tian Jian-Ping Lu Cheng-Wei Shao Characteristics of culprit intracranial plaque without substantial stenosis in ischemic stroke using three-dimensional high-resolution vessel wall magnetic resonance imaging Frontiers in Neuroscience 3D high-resolution magnetic resonance imaging intracranial non-stenotic atherosclerotic plaques ischemic stroke histogram features diagnostic efficacy |
| title | Characteristics of culprit intracranial plaque without substantial stenosis in ischemic stroke using three-dimensional high-resolution vessel wall magnetic resonance imaging |
| title_full | Characteristics of culprit intracranial plaque without substantial stenosis in ischemic stroke using three-dimensional high-resolution vessel wall magnetic resonance imaging |
| title_fullStr | Characteristics of culprit intracranial plaque without substantial stenosis in ischemic stroke using three-dimensional high-resolution vessel wall magnetic resonance imaging |
| title_full_unstemmed | Characteristics of culprit intracranial plaque without substantial stenosis in ischemic stroke using three-dimensional high-resolution vessel wall magnetic resonance imaging |
| title_short | Characteristics of culprit intracranial plaque without substantial stenosis in ischemic stroke using three-dimensional high-resolution vessel wall magnetic resonance imaging |
| title_sort | characteristics of culprit intracranial plaque without substantial stenosis in ischemic stroke using three dimensional high resolution vessel wall magnetic resonance imaging |
| topic | 3D high-resolution magnetic resonance imaging intracranial non-stenotic atherosclerotic plaques ischemic stroke histogram features diagnostic efficacy |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1160018/full |
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