The Effects of Oral Probiotics on Type 2 Diabetes Mellitus (T2DM): A Clinical Trial Systematic Literature Review
Type 2 diabetes mellitus (T2DM) remains a global health concern. Emerging clinical trial (CT) evidence suggests that probiotic intervention may promote a healthy gut microbiome in individuals with T2DM, thereby improving management of the disease. This systematic literature review summarizes thirty-...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-11-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/15/21/4690 |
| _version_ | 1797631528911503360 |
|---|---|
| author | Simon Paquette Sean C. Thomas Krishnan Venkataraman Vasu D. Appanna Sujeenthar Tharmalingam |
| author_facet | Simon Paquette Sean C. Thomas Krishnan Venkataraman Vasu D. Appanna Sujeenthar Tharmalingam |
| author_sort | Simon Paquette |
| collection | DOAJ |
| description | Type 2 diabetes mellitus (T2DM) remains a global health concern. Emerging clinical trial (CT) evidence suggests that probiotic intervention may promote a healthy gut microbiome in individuals with T2DM, thereby improving management of the disease. This systematic literature review summarizes thirty-three CTs investigating the use of oral probiotics for the management of T2DM. Here, twenty-one studies (64%) demonstrated an improvement in at least one glycemic parameter, while fifteen studies (45%) showed an improvement in at least one lipid parameter. However, no article in this review was able to establish a uniform decrease in glycemic, lipid, or blood pressure profiles. The lack of consistency across the studies may be attributed to differences in probiotic composition, duration of probiotic consumption, and probiotic dose. An interesting finding of this literature review was the beneficial trend of metformin and probiotic co-administration. Here, patients with T2DM taking metformin demonstrated enhanced glycemic control via the co-administration of probiotics. Taken together, the overall positive findings reported across the studies in combination with minimal adverse effects constitute ground for further quality CTs. This review provides recommendations for future CTs that may address the shortcomings of the current studies and help to extract useful data from future investigations of the use of probiotics in T2DM management. |
| first_indexed | 2024-03-11T11:23:53Z |
| format | Article |
| id | doaj.art-efdf2196af9e403c84fcaa960c31b541 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T11:23:53Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-efdf2196af9e403c84fcaa960c31b5412023-11-10T15:10:03ZengMDPI AGNutrients2072-66432023-11-011521469010.3390/nu15214690The Effects of Oral Probiotics on Type 2 Diabetes Mellitus (T2DM): A Clinical Trial Systematic Literature ReviewSimon Paquette0Sean C. Thomas1Krishnan Venkataraman2Vasu D. Appanna3Sujeenthar Tharmalingam4Medical Sciences Division, NOSM University, Sudbury, ON P3E 2C6, CanadaMedical Sciences Division, NOSM University, Sudbury, ON P3E 2C6, CanadaMedical Sciences Division, NOSM University, Sudbury, ON P3E 2C6, CanadaSchool of Natural Sciences, Laurentian University, Sudbury, ON P3E 2C6, CanadaMedical Sciences Division, NOSM University, Sudbury, ON P3E 2C6, CanadaType 2 diabetes mellitus (T2DM) remains a global health concern. Emerging clinical trial (CT) evidence suggests that probiotic intervention may promote a healthy gut microbiome in individuals with T2DM, thereby improving management of the disease. This systematic literature review summarizes thirty-three CTs investigating the use of oral probiotics for the management of T2DM. Here, twenty-one studies (64%) demonstrated an improvement in at least one glycemic parameter, while fifteen studies (45%) showed an improvement in at least one lipid parameter. However, no article in this review was able to establish a uniform decrease in glycemic, lipid, or blood pressure profiles. The lack of consistency across the studies may be attributed to differences in probiotic composition, duration of probiotic consumption, and probiotic dose. An interesting finding of this literature review was the beneficial trend of metformin and probiotic co-administration. Here, patients with T2DM taking metformin demonstrated enhanced glycemic control via the co-administration of probiotics. Taken together, the overall positive findings reported across the studies in combination with minimal adverse effects constitute ground for further quality CTs. This review provides recommendations for future CTs that may address the shortcomings of the current studies and help to extract useful data from future investigations of the use of probiotics in T2DM management.https://www.mdpi.com/2072-6643/15/21/4690probiotictype 2 diabetes mellitusT2DMglucosegut healthglycemic index |
| spellingShingle | Simon Paquette Sean C. Thomas Krishnan Venkataraman Vasu D. Appanna Sujeenthar Tharmalingam The Effects of Oral Probiotics on Type 2 Diabetes Mellitus (T2DM): A Clinical Trial Systematic Literature Review Nutrients probiotic type 2 diabetes mellitus T2DM glucose gut health glycemic index |
| title | The Effects of Oral Probiotics on Type 2 Diabetes Mellitus (T2DM): A Clinical Trial Systematic Literature Review |
| title_full | The Effects of Oral Probiotics on Type 2 Diabetes Mellitus (T2DM): A Clinical Trial Systematic Literature Review |
| title_fullStr | The Effects of Oral Probiotics on Type 2 Diabetes Mellitus (T2DM): A Clinical Trial Systematic Literature Review |
| title_full_unstemmed | The Effects of Oral Probiotics on Type 2 Diabetes Mellitus (T2DM): A Clinical Trial Systematic Literature Review |
| title_short | The Effects of Oral Probiotics on Type 2 Diabetes Mellitus (T2DM): A Clinical Trial Systematic Literature Review |
| title_sort | effects of oral probiotics on type 2 diabetes mellitus t2dm a clinical trial systematic literature review |
| topic | probiotic type 2 diabetes mellitus T2DM glucose gut health glycemic index |
| url | https://www.mdpi.com/2072-6643/15/21/4690 |
| work_keys_str_mv | AT simonpaquette theeffectsoforalprobioticsontype2diabetesmellitust2dmaclinicaltrialsystematicliteraturereview AT seancthomas theeffectsoforalprobioticsontype2diabetesmellitust2dmaclinicaltrialsystematicliteraturereview AT krishnanvenkataraman theeffectsoforalprobioticsontype2diabetesmellitust2dmaclinicaltrialsystematicliteraturereview AT vasudappanna theeffectsoforalprobioticsontype2diabetesmellitust2dmaclinicaltrialsystematicliteraturereview AT sujeenthartharmalingam theeffectsoforalprobioticsontype2diabetesmellitust2dmaclinicaltrialsystematicliteraturereview AT simonpaquette effectsoforalprobioticsontype2diabetesmellitust2dmaclinicaltrialsystematicliteraturereview AT seancthomas effectsoforalprobioticsontype2diabetesmellitust2dmaclinicaltrialsystematicliteraturereview AT krishnanvenkataraman effectsoforalprobioticsontype2diabetesmellitust2dmaclinicaltrialsystematicliteraturereview AT vasudappanna effectsoforalprobioticsontype2diabetesmellitust2dmaclinicaltrialsystematicliteraturereview AT sujeenthartharmalingam effectsoforalprobioticsontype2diabetesmellitust2dmaclinicaltrialsystematicliteraturereview |