p300 Acetylates JHDM1A to inhibit osteosarcoma carcinogenesis

p300 Acetylates JHDM1A to inhibit osteosarcoma carcinogenesis

JHDM1A participates in cancer development via demethylate dimethyl histone H3 lysine 36 (H3K36me2). p300 is an intrinsic acetyltransferase. This study explored the acetyltransferase activity of p300 on JHDM1A and analyzed the JHDM1A acetylation on H3K36me2 demethylation in osteosarcoma. Co-immunopre...

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Bibliographic Details
Main Authors: Yongkun Wang, Baozhen Sun, Qiao Zhang, Hang Dong, Jingzhe Zhang
Format: Article
Language:English
Published: Taylor & Francis Group 2019-12-01
Series:Artificial Cells, Nanomedicine, and Biotechnology
Subjects:
Osteosarcoma
p300
JHDM1A
H3K36me2
p21
puma
Online Access:https://www.tandfonline.com/doi/10.1080/21691401.2019.1638790

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