A review of serological tests to assist diagnosis of reactive arthritis: critical appraisal on methodologies
On a population-based level, the incidence of reactive arthritis (ReA) is 0.6-27/100,000. The definition of ReA varies and its pathogenesis is not yet clear. Attempts in basic immunology to suggest hypotheses for proliferation of forbidden B cell clones, molecular mimicry and involvement of cross-re...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-12-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00418/full |
| _version_ | 1818014567647674368 |
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| author | Tamara eTuuminen Tamara eTuuminen Kari eLounamo Marjatta eLeirisalo-Repo |
| author_facet | Tamara eTuuminen Tamara eTuuminen Kari eLounamo Marjatta eLeirisalo-Repo |
| author_sort | Tamara eTuuminen |
| collection | DOAJ |
| description | On a population-based level, the incidence of reactive arthritis (ReA) is 0.6-27/100,000. The definition of ReA varies and its pathogenesis is not yet clear. Attempts in basic immunology to suggest hypotheses for proliferation of forbidden B cell clones, molecular mimicry and involvement of cross-reactive antibodies are helpful but not sufficient. Importantly, for the clinical diagnosis of the preceding infection, serology is widely used. Unfortunately, the accuracy of associations between serologic findings and clinical conclusions is plagued by poor standardisation of methods. So far, few attempts have been done to examine the pitfalls of different approaches. Here, we review several serologic techniques, their performance and limitations. We will focus only on serology for Yersinia, Campylobacter, Salmonella and Chlamydia trachomatis because these bacteria have a longer history of being associated with ReA. We also address controversies regarding the role of serology for some other bacteria linked to autoimmune disorders. |
| first_indexed | 2024-04-14T06:46:12Z |
| format | Article |
| id | doaj.art-efdfad0c5e5f46f2b1783121c8bdc280 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-14T06:46:12Z |
| publishDate | 2013-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-efdfad0c5e5f46f2b1783121c8bdc2802022-12-22T02:07:10ZengFrontiers Media S.A.Frontiers in Immunology1664-32242013-12-01410.3389/fimmu.2013.0041861768A review of serological tests to assist diagnosis of reactive arthritis: critical appraisal on methodologiesTamara eTuuminen0Tamara eTuuminen1Kari eLounamo2Marjatta eLeirisalo-Repo3University of HelsinkiEastern Finland Laboratory Centre Joint Authority EnterpriseHealth Centre of LahtiUniversity of HelsinkiOn a population-based level, the incidence of reactive arthritis (ReA) is 0.6-27/100,000. The definition of ReA varies and its pathogenesis is not yet clear. Attempts in basic immunology to suggest hypotheses for proliferation of forbidden B cell clones, molecular mimicry and involvement of cross-reactive antibodies are helpful but not sufficient. Importantly, for the clinical diagnosis of the preceding infection, serology is widely used. Unfortunately, the accuracy of associations between serologic findings and clinical conclusions is plagued by poor standardisation of methods. So far, few attempts have been done to examine the pitfalls of different approaches. Here, we review several serologic techniques, their performance and limitations. We will focus only on serology for Yersinia, Campylobacter, Salmonella and Chlamydia trachomatis because these bacteria have a longer history of being associated with ReA. We also address controversies regarding the role of serology for some other bacteria linked to autoimmune disorders.http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00418/fullCampylobacterChlamydia trachomatisSalmonellaSerologyYersiniareactive arthritis |
| spellingShingle | Tamara eTuuminen Tamara eTuuminen Kari eLounamo Marjatta eLeirisalo-Repo A review of serological tests to assist diagnosis of reactive arthritis: critical appraisal on methodologies Frontiers in Immunology Campylobacter Chlamydia trachomatis Salmonella Serology Yersinia reactive arthritis |
| title | A review of serological tests to assist diagnosis of reactive arthritis: critical appraisal on methodologies |
| title_full | A review of serological tests to assist diagnosis of reactive arthritis: critical appraisal on methodologies |
| title_fullStr | A review of serological tests to assist diagnosis of reactive arthritis: critical appraisal on methodologies |
| title_full_unstemmed | A review of serological tests to assist diagnosis of reactive arthritis: critical appraisal on methodologies |
| title_short | A review of serological tests to assist diagnosis of reactive arthritis: critical appraisal on methodologies |
| title_sort | review of serological tests to assist diagnosis of reactive arthritis critical appraisal on methodologies |
| topic | Campylobacter Chlamydia trachomatis Salmonella Serology Yersinia reactive arthritis |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00418/full |
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