Hydrogels for Salivary Gland Tissue Engineering
Mimicking the complex architecture of salivary glands (SGs) outside their native niche is challenging due their multicellular and highly branched organization. However, significant progress has been made to recapitulate the gland structure and function using several in vitro and ex vivo models. Hydr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/8/11/730 |
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| author | Sangeeth Pillai Jose G. Munguia-Lopez Simon D. Tran |
| author_facet | Sangeeth Pillai Jose G. Munguia-Lopez Simon D. Tran |
| author_sort | Sangeeth Pillai |
| collection | DOAJ |
| description | Mimicking the complex architecture of salivary glands (SGs) outside their native niche is challenging due their multicellular and highly branched organization. However, significant progress has been made to recapitulate the gland structure and function using several in vitro and ex vivo models. Hydrogels are polymers with the potential to retain a large volume of water inside their three-dimensional structure, thus simulating extracellular matrix properties that are essential for the cell and tissue integrity. Hydrogel-based culture of SG cells has seen a tremendous success in terms of developing platforms for cell expansion, building an artificial gland, and for use in transplantation to rescue loss of SG function. Both natural and synthetic hydrogels have been used widely in SG tissue engineering applications owing to their properties that support the proliferation, reorganization, and polarization of SG epithelial cells. While recent improvements in hydrogel properties are essential to establish more sophisticated models, the emphasis should still be made towards supporting factors such as mechanotransduction and associated signaling cues. In this concise review, we discuss considerations of an ideal hydrogel-based biomaterial for SG engineering and their associated signaling pathways. We also discuss the current advances made in natural and synthetic hydrogels for SG tissue engineering applications. |
| first_indexed | 2024-03-09T19:04:01Z |
| format | Article |
| id | doaj.art-efe09df98c104044aba1f6cc5289526e |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-09T19:04:01Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-efe09df98c104044aba1f6cc5289526e2023-11-24T04:46:52ZengMDPI AGGels2310-28612022-11-0181173010.3390/gels8110730Hydrogels for Salivary Gland Tissue EngineeringSangeeth Pillai0Jose G. Munguia-Lopez1Simon D. Tran2McGill Craniofacial Tissue Engineering and Stem Cells Laboratory, Faculty of Dental Medicine and Oral Health Sciences, McGill University, 3640 Rue University, Montreal, QC H3A 0C7, CanadaMcGill Craniofacial Tissue Engineering and Stem Cells Laboratory, Faculty of Dental Medicine and Oral Health Sciences, McGill University, 3640 Rue University, Montreal, QC H3A 0C7, CanadaMcGill Craniofacial Tissue Engineering and Stem Cells Laboratory, Faculty of Dental Medicine and Oral Health Sciences, McGill University, 3640 Rue University, Montreal, QC H3A 0C7, CanadaMimicking the complex architecture of salivary glands (SGs) outside their native niche is challenging due their multicellular and highly branched organization. However, significant progress has been made to recapitulate the gland structure and function using several in vitro and ex vivo models. Hydrogels are polymers with the potential to retain a large volume of water inside their three-dimensional structure, thus simulating extracellular matrix properties that are essential for the cell and tissue integrity. Hydrogel-based culture of SG cells has seen a tremendous success in terms of developing platforms for cell expansion, building an artificial gland, and for use in transplantation to rescue loss of SG function. Both natural and synthetic hydrogels have been used widely in SG tissue engineering applications owing to their properties that support the proliferation, reorganization, and polarization of SG epithelial cells. While recent improvements in hydrogel properties are essential to establish more sophisticated models, the emphasis should still be made towards supporting factors such as mechanotransduction and associated signaling cues. In this concise review, we discuss considerations of an ideal hydrogel-based biomaterial for SG engineering and their associated signaling pathways. We also discuss the current advances made in natural and synthetic hydrogels for SG tissue engineering applications.https://www.mdpi.com/2310-2861/8/11/730salivary glandshydrogelsECMmechanotransductionsignaling pathways |
| spellingShingle | Sangeeth Pillai Jose G. Munguia-Lopez Simon D. Tran Hydrogels for Salivary Gland Tissue Engineering Gels salivary glands hydrogels ECM mechanotransduction signaling pathways |
| title | Hydrogels for Salivary Gland Tissue Engineering |
| title_full | Hydrogels for Salivary Gland Tissue Engineering |
| title_fullStr | Hydrogels for Salivary Gland Tissue Engineering |
| title_full_unstemmed | Hydrogels for Salivary Gland Tissue Engineering |
| title_short | Hydrogels for Salivary Gland Tissue Engineering |
| title_sort | hydrogels for salivary gland tissue engineering |
| topic | salivary glands hydrogels ECM mechanotransduction signaling pathways |
| url | https://www.mdpi.com/2310-2861/8/11/730 |
| work_keys_str_mv | AT sangeethpillai hydrogelsforsalivaryglandtissueengineering AT josegmunguialopez hydrogelsforsalivaryglandtissueengineering AT simondtran hydrogelsforsalivaryglandtissueengineering |