The mini-IDLE 3D biomimetic culture assay enables interrogation of mechanisms governing muscle stem cell quiescence and niche repopulation

The mini-IDLE 3D biomimetic culture assay enables interrogation of mechanisms governing muscle stem cell quiescence and niche repopulation

Adult skeletal muscle harbours a population of muscle stem cells (MuSCs) that are required for repair after tissue injury. In youth, MuSCs return to a reversible state of cell-cycle arrest termed ‘quiescence’ after injury resolution. Conversely, some MuSCs in aged muscle remain semi-activated, causi...

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Bibliographic Details
Main Authors: Erik Jacques, Yinni Kuang, Allison P Kann, Fabien Le Grand, Robert S Krauss, Penney M Gilbert
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-12-01
Series:eLife
Subjects:
muscle stem cell
skeletal muscle
quiescence
inactivation
in vitro assay
niche
Online Access:https://elifesciences.org/articles/81738

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