Specific MRP4 Inhibitor Ceefourin-1 Enhances Apoptosis Induced by 6-Mercaptopurine in Jurkat Leukemic Cells, but Not in Normal Lymphoblast Cell Line CRL-1991

Specific MRP4 Inhibitor Ceefourin-1 Enhances Apoptosis Induced by 6-Mercaptopurine in Jurkat Leukemic Cells, but Not in Normal Lymphoblast Cell Line CRL-1991

<i>Background and objectives</i>: The multidrug resistance protein 4 (MRP4) is a member of the ABC transporter, which has been extensively related to many types of cancer including leukemia. MRP4 overexpression and activity over the efflux of some chemotherapeutic drugs are the main caus...

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Bibliographic Details
Main Authors: Edgardo Becerra, Laura Berumen, Valeria Soto-Ontiveros, Guadalupe García-Alcocer
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Medicina
Subjects:
6-mercaptopurine
MRP4
leukemia
ceefourin-1
MRP4 inhibitor
apoptosis
Online Access:https://www.mdpi.com/1648-9144/58/6/695

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