RAI14 Promotes Melanoma Progression by Regulating the FBXO32/c-MYC Pathway
Melanoma originates from the malignant transformation of melanocytes. Compared with other skin cancers, melanoma has a higher fatality rate. The 5-year survival rate of patients with early-stage primary melanoma through surgical resection can reach more than 90%. However, the 5-year survival rate of...
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MDPI AG
2022-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/19/12036 |
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| author | Jie Xu Pengfei Shi Fanwei Xia Xuan Zhao Junfan Chen Rui Geng Hongjuan Cui Liqun Yang |
| author_facet | Jie Xu Pengfei Shi Fanwei Xia Xuan Zhao Junfan Chen Rui Geng Hongjuan Cui Liqun Yang |
| author_sort | Jie Xu |
| collection | DOAJ |
| description | Melanoma originates from the malignant transformation of melanocytes. Compared with other skin cancers, melanoma has a higher fatality rate. The 5-year survival rate of patients with early-stage primary melanoma through surgical resection can reach more than 90%. However, the 5-year survival rate of patients with metastatic melanoma is only 25%. Therefore, accurate assessment of melanoma progression is critical. Previous studies have found that Retinoic Acid Induced 14(RAI14) is critical in tumorigenesis. However, the biological function of RAI14 for the development of melanoma is unclear. In this study, RAI14 is highly expressed in melanoma and correlated with prognosis. The expression of RAI14 can affect the proliferation, migration and invasion of melanoma cells. F-Box Protein 32(FBXO32) is an E3 ubiquitin ligase of c-MYC. We found that RAI14 affects the transcriptional expression of FBXO32 and regulates the stability of c-MYC. These results suggest that RAI14 play an important role in the growth of melanoma and is expected to be a therapeutic target for melanoma. |
| first_indexed | 2024-03-09T21:36:47Z |
| format | Article |
| id | doaj.art-efe4f978a7fd4854999af617278ee821 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:36:47Z |
| publishDate | 2022-10-01 |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-efe4f978a7fd4854999af617278ee8212023-11-23T20:43:31ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-10-0123191203610.3390/ijms231912036RAI14 Promotes Melanoma Progression by Regulating the FBXO32/c-MYC PathwayJie Xu0Pengfei Shi1Fanwei Xia2Xuan Zhao3Junfan Chen4Rui Geng5Hongjuan Cui6Liqun Yang7State Key Laboratory of Silkworm Genome Biology, Institute of Sericulture and Systems Biology, Southwest University, Chongqing 400716, ChinaState Key Laboratory of Silkworm Genome Biology, Institute of Sericulture and Systems Biology, Southwest University, Chongqing 400716, ChinaState Key Laboratory of Silkworm Genome Biology, Institute of Sericulture and Systems Biology, Southwest University, Chongqing 400716, ChinaState Key Laboratory of Silkworm Genome Biology, Institute of Sericulture and Systems Biology, Southwest University, Chongqing 400716, ChinaState Key Laboratory of Silkworm Genome Biology, Institute of Sericulture and Systems Biology, Southwest University, Chongqing 400716, ChinaState Key Laboratory of Silkworm Genome Biology, Institute of Sericulture and Systems Biology, Southwest University, Chongqing 400716, ChinaState Key Laboratory of Silkworm Genome Biology, Institute of Sericulture and Systems Biology, Southwest University, Chongqing 400716, ChinaState Key Laboratory of Silkworm Genome Biology, Institute of Sericulture and Systems Biology, Southwest University, Chongqing 400716, ChinaMelanoma originates from the malignant transformation of melanocytes. Compared with other skin cancers, melanoma has a higher fatality rate. The 5-year survival rate of patients with early-stage primary melanoma through surgical resection can reach more than 90%. However, the 5-year survival rate of patients with metastatic melanoma is only 25%. Therefore, accurate assessment of melanoma progression is critical. Previous studies have found that Retinoic Acid Induced 14(RAI14) is critical in tumorigenesis. However, the biological function of RAI14 for the development of melanoma is unclear. In this study, RAI14 is highly expressed in melanoma and correlated with prognosis. The expression of RAI14 can affect the proliferation, migration and invasion of melanoma cells. F-Box Protein 32(FBXO32) is an E3 ubiquitin ligase of c-MYC. We found that RAI14 affects the transcriptional expression of FBXO32 and regulates the stability of c-MYC. These results suggest that RAI14 play an important role in the growth of melanoma and is expected to be a therapeutic target for melanoma.https://www.mdpi.com/1422-0067/23/19/12036RAI14c-MYCubiquitinationmelanomaproliferation |
| spellingShingle | Jie Xu Pengfei Shi Fanwei Xia Xuan Zhao Junfan Chen Rui Geng Hongjuan Cui Liqun Yang RAI14 Promotes Melanoma Progression by Regulating the FBXO32/c-MYC Pathway International Journal of Molecular Sciences RAI14 c-MYC ubiquitination melanoma proliferation |
| title | RAI14 Promotes Melanoma Progression by Regulating the FBXO32/c-MYC Pathway |
| title_full | RAI14 Promotes Melanoma Progression by Regulating the FBXO32/c-MYC Pathway |
| title_fullStr | RAI14 Promotes Melanoma Progression by Regulating the FBXO32/c-MYC Pathway |
| title_full_unstemmed | RAI14 Promotes Melanoma Progression by Regulating the FBXO32/c-MYC Pathway |
| title_short | RAI14 Promotes Melanoma Progression by Regulating the FBXO32/c-MYC Pathway |
| title_sort | rai14 promotes melanoma progression by regulating the fbxo32 c myc pathway |
| topic | RAI14 c-MYC ubiquitination melanoma proliferation |
| url | https://www.mdpi.com/1422-0067/23/19/12036 |
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