A case of diquat poisoning in pigs
Diquat is a bipyridyl compound which belongs to the group of herbicides. Its activity is based on the liberation of the superoxide anion radical and, subsequently, hydrogen peroxide, leading to tissue destruction by oxidative stress. Acute poisoning is associated with high mortality within several h...
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| Format: | Article |
| Language: | English |
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Czech Academy of Agricultural Sciences
2019-11-01
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| Series: | Veterinární Medicína |
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| Online Access: | https://vetmed.agriculturejournals.cz/artkey/vet-201911-0006_a-case-of-diquat-poisoning-in-pigs.php |
| _version_ | 1797897481960292352 |
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| author | Zuzana Siroka Martin Svoboda Zdenka Svobodova Ivan Nagl |
| author_facet | Zuzana Siroka Martin Svoboda Zdenka Svobodova Ivan Nagl |
| author_sort | Zuzana Siroka |
| collection | DOAJ |
| description | Diquat is a bipyridyl compound which belongs to the group of herbicides. Its activity is based on the liberation of the superoxide anion radical and, subsequently, hydrogen peroxide, leading to tissue destruction by oxidative stress. Acute poisoning is associated with high mortality within several hours to a few days. The reported case of poisoning occurred on a commercial farm. The fattening pigs of the Landrace and Large White breeds were affected. The pigs were kept on a deep litter. Reglone (active ingredient diquat dibromide, 200 g/l) was used on the farm fields to desiccate the clover crop. The dry clover straw was harvested and stored for approximately a month and then used as a litter. In total, 50 pigs were affected. The onset of the poisoning was very fast. Within eight hours after the litter administration, 20 animals died. The only clinical sign seen was severe haemorrhagic dermatitis. The pathological examination revealed acute superficial haemorrhagic dermatitis on the belly, the snout and the ears of the affected pigs. Hyperaemia of the tonsils, pharynx and oesophagus was diagnosed, as well as a pronounced hyperaemia of the stomach fundus. In the distal part of the trachea, there was a dense, white foam. The lungs were congested, with focal emphysema. The liver was slightly hyperaemic. The histological examination revealed a massive haemostasis in liver and diffuse acute polymorphonuclear hepatitis. The other organs were without changes. The examination revealed acute poisoning caused by the large body surface areas contacting with a toxic substance. The pigs that survived were immediately removed to a non-contaminated area. The changes on their skin were not so extensive compared to the dead ones. Within 5-7 days after the exposure to diquat, the skin lesions healed. |
| first_indexed | 2024-04-10T07:59:09Z |
| format | Article |
| id | doaj.art-efe7bf73f41a4f98ad0e2c1aa1f7ba94 |
| institution | Directory Open Access Journal |
| issn | 0375-8427 1805-9392 |
| language | English |
| last_indexed | 2024-04-10T07:59:09Z |
| publishDate | 2019-11-01 |
| publisher | Czech Academy of Agricultural Sciences |
| record_format | Article |
| series | Veterinární Medicína |
| spelling | doaj.art-efe7bf73f41a4f98ad0e2c1aa1f7ba942023-02-23T03:50:53ZengCzech Academy of Agricultural SciencesVeterinární Medicína0375-84271805-93922019-11-01641150551110.17221/87/2019-VETMEDvet-201911-0006A case of diquat poisoning in pigsZuzana Siroka0Martin Svoboda1Zdenka Svobodova2Ivan Nagl3Department of Animal Protection, Welfare and Behaviour, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech RepublicDepartment of Animal Protection, Welfare and Behaviour, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech RepublicDepartment of Animal Protection, Welfare and Behaviour, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech RepublicDepartment of Pathology and Parasitology, State Veterinary Institute Praha, Czech RepublicDiquat is a bipyridyl compound which belongs to the group of herbicides. Its activity is based on the liberation of the superoxide anion radical and, subsequently, hydrogen peroxide, leading to tissue destruction by oxidative stress. Acute poisoning is associated with high mortality within several hours to a few days. The reported case of poisoning occurred on a commercial farm. The fattening pigs of the Landrace and Large White breeds were affected. The pigs were kept on a deep litter. Reglone (active ingredient diquat dibromide, 200 g/l) was used on the farm fields to desiccate the clover crop. The dry clover straw was harvested and stored for approximately a month and then used as a litter. In total, 50 pigs were affected. The onset of the poisoning was very fast. Within eight hours after the litter administration, 20 animals died. The only clinical sign seen was severe haemorrhagic dermatitis. The pathological examination revealed acute superficial haemorrhagic dermatitis on the belly, the snout and the ears of the affected pigs. Hyperaemia of the tonsils, pharynx and oesophagus was diagnosed, as well as a pronounced hyperaemia of the stomach fundus. In the distal part of the trachea, there was a dense, white foam. The lungs were congested, with focal emphysema. The liver was slightly hyperaemic. The histological examination revealed a massive haemostasis in liver and diffuse acute polymorphonuclear hepatitis. The other organs were without changes. The examination revealed acute poisoning caused by the large body surface areas contacting with a toxic substance. The pigs that survived were immediately removed to a non-contaminated area. The changes on their skin were not so extensive compared to the dead ones. Within 5-7 days after the exposure to diquat, the skin lesions healed.https://vetmed.agriculturejournals.cz/artkey/vet-201911-0006_a-case-of-diquat-poisoning-in-pigs.phpherbicidebipyridyl derivatesdesiccanthaemorrhagic dermatitisoxidative stressreglone |
| spellingShingle | Zuzana Siroka Martin Svoboda Zdenka Svobodova Ivan Nagl A case of diquat poisoning in pigs Veterinární Medicína herbicide bipyridyl derivates desiccant haemorrhagic dermatitis oxidative stress reglone |
| title | A case of diquat poisoning in pigs |
| title_full | A case of diquat poisoning in pigs |
| title_fullStr | A case of diquat poisoning in pigs |
| title_full_unstemmed | A case of diquat poisoning in pigs |
| title_short | A case of diquat poisoning in pigs |
| title_sort | case of diquat poisoning in pigs |
| topic | herbicide bipyridyl derivates desiccant haemorrhagic dermatitis oxidative stress reglone |
| url | https://vetmed.agriculturejournals.cz/artkey/vet-201911-0006_a-case-of-diquat-poisoning-in-pigs.php |
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