Neutrophil and Natural Killer Cell Interactions in Cancers: Dangerous Liaisons Instructing Immunosuppression and Angiogenesis
The tumor immune microenvironment (TIME) has largely been reported to cooperate on tumor onset and progression, as a consequence of the phenotype/functional plasticity and adaptation capabilities of tumor-infiltrating and tumor-associated immune cells. Immune cells within the tumor micro (tissue-loc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/9/12/1488 |
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| author | Maria Teresa Palano Matteo Gallazzi Martina Cucchiara Andrea De Lerma Barbaro Daniela Gallo Barbara Bassani Antonino Bruno Lorenzo Mortara |
| author_facet | Maria Teresa Palano Matteo Gallazzi Martina Cucchiara Andrea De Lerma Barbaro Daniela Gallo Barbara Bassani Antonino Bruno Lorenzo Mortara |
| author_sort | Maria Teresa Palano |
| collection | DOAJ |
| description | The tumor immune microenvironment (TIME) has largely been reported to cooperate on tumor onset and progression, as a consequence of the phenotype/functional plasticity and adaptation capabilities of tumor-infiltrating and tumor-associated immune cells. Immune cells within the tumor micro (tissue-local) and macro (peripheral blood) environment closely interact by cell-to-cell contact and/or via soluble factors, also generating a tumor-permissive soil. These dangerous liaisons have been investigated for pillars of tumor immunology, such as tumor associated macrophages and T cell subsets. Here, we reviewed and discussed the contribution of selected innate immunity effector cells, namely neutrophils and natural killer cells, as “soloists” or by their “dangerous liaisons”, in favoring tumor progression by dissecting the cellular and molecular mechanisms involved. |
| first_indexed | 2024-03-10T03:56:36Z |
| format | Article |
| id | doaj.art-efe99bb488924e03901d708d69f3f4d3 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T03:56:36Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-efe99bb488924e03901d708d69f3f4d32023-11-23T10:55:02ZengMDPI AGVaccines2076-393X2021-12-01912148810.3390/vaccines9121488Neutrophil and Natural Killer Cell Interactions in Cancers: Dangerous Liaisons Instructing Immunosuppression and AngiogenesisMaria Teresa Palano0Matteo Gallazzi1Martina Cucchiara2Andrea De Lerma Barbaro3Daniela Gallo4Barbara Bassani5Antonino Bruno6Lorenzo Mortara7Laboratory of Innate Immunity, Unit of Molecular Pathology, Biochemistry, and Immunology, IRCCS MultiMedica, 20138 Milan, ItalyLaboratory of Immunology and General Pathology, Department of Biotechnology and Life Sciences, University of Insubria, 21100 Varese, ItalyLaboratory of Immunology and General Pathology, Department of Biotechnology and Life Sciences, University of Insubria, 21100 Varese, ItalyLaboratory of Comparative Physiopathology, Department of Biotechnology and Life Sciences, University of Insubria, 20145 Varese, ItalyEndocrine Unit, Department of Medicine and Surgery, University of Insubria, ASST dei Sette Laghi, 21100 Varese, ItalyMolecular Immunology Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, ItalyLaboratory of Innate Immunity, Unit of Molecular Pathology, Biochemistry, and Immunology, IRCCS MultiMedica, 20138 Milan, ItalyLaboratory of Immunology and General Pathology, Department of Biotechnology and Life Sciences, University of Insubria, 21100 Varese, ItalyThe tumor immune microenvironment (TIME) has largely been reported to cooperate on tumor onset and progression, as a consequence of the phenotype/functional plasticity and adaptation capabilities of tumor-infiltrating and tumor-associated immune cells. Immune cells within the tumor micro (tissue-local) and macro (peripheral blood) environment closely interact by cell-to-cell contact and/or via soluble factors, also generating a tumor-permissive soil. These dangerous liaisons have been investigated for pillars of tumor immunology, such as tumor associated macrophages and T cell subsets. Here, we reviewed and discussed the contribution of selected innate immunity effector cells, namely neutrophils and natural killer cells, as “soloists” or by their “dangerous liaisons”, in favoring tumor progression by dissecting the cellular and molecular mechanisms involved.https://www.mdpi.com/2076-393X/9/12/1488neutrophilsnatural killer cellsneutrophil-NK cell crosstalkimmunosuppressiontumor angiogenesistumor microenvironment |
| spellingShingle | Maria Teresa Palano Matteo Gallazzi Martina Cucchiara Andrea De Lerma Barbaro Daniela Gallo Barbara Bassani Antonino Bruno Lorenzo Mortara Neutrophil and Natural Killer Cell Interactions in Cancers: Dangerous Liaisons Instructing Immunosuppression and Angiogenesis Vaccines neutrophils natural killer cells neutrophil-NK cell crosstalk immunosuppression tumor angiogenesis tumor microenvironment |
| title | Neutrophil and Natural Killer Cell Interactions in Cancers: Dangerous Liaisons Instructing Immunosuppression and Angiogenesis |
| title_full | Neutrophil and Natural Killer Cell Interactions in Cancers: Dangerous Liaisons Instructing Immunosuppression and Angiogenesis |
| title_fullStr | Neutrophil and Natural Killer Cell Interactions in Cancers: Dangerous Liaisons Instructing Immunosuppression and Angiogenesis |
| title_full_unstemmed | Neutrophil and Natural Killer Cell Interactions in Cancers: Dangerous Liaisons Instructing Immunosuppression and Angiogenesis |
| title_short | Neutrophil and Natural Killer Cell Interactions in Cancers: Dangerous Liaisons Instructing Immunosuppression and Angiogenesis |
| title_sort | neutrophil and natural killer cell interactions in cancers dangerous liaisons instructing immunosuppression and angiogenesis |
| topic | neutrophils natural killer cells neutrophil-NK cell crosstalk immunosuppression tumor angiogenesis tumor microenvironment |
| url | https://www.mdpi.com/2076-393X/9/12/1488 |
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