A multifunctional biomimetic nanoplatform for image-guideded photothermal-ferroptotic synergistic osteosarcoma therapy
Much effort has been devoted to improving treatment efficiency for osteosarcoma (OS). However, most current approaches result in poor therapeutic responses, thus indicating the need for the development of other therapeutic options. This study developed a multifunctional nanoparticle, PDA-MOF-E-M, an...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2024-06-01
|
| Series: | Bioactive Materials |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X24000525 |
| _version_ | 1797272453951520768 |
|---|---|
| author | Yu-jie Liu Su-he Dong Wen-hao Hu Qiao-ling Chen Shao-fu Zhang Kai Song Zhen-chuan Han Meng-meng Li Zhi-tao Han Wei-bo Liu Xue-song Zhang |
| author_facet | Yu-jie Liu Su-he Dong Wen-hao Hu Qiao-ling Chen Shao-fu Zhang Kai Song Zhen-chuan Han Meng-meng Li Zhi-tao Han Wei-bo Liu Xue-song Zhang |
| author_sort | Yu-jie Liu |
| collection | DOAJ |
| description | Much effort has been devoted to improving treatment efficiency for osteosarcoma (OS). However, most current approaches result in poor therapeutic responses, thus indicating the need for the development of other therapeutic options. This study developed a multifunctional nanoparticle, PDA-MOF-E-M, an aggregation of OS targeting, programmed death targeting, and near-infrared (NIR)-aided targeting. At the same time, a multifunctional nanoparticle that utilises Fe-MOFs to create a cellular iron-rich environment and erastin as a ferroptosis inducer while ensuring targeted delivery to OS cells through cell membrane encapsulation is presented. The combination of PDA-MOF-E-M and PTT increased intracellular ROS and LPO levels and induced ferroptosis-related protein expression. A PDA-based PTT combined with erastin showed significant synergistic therapeutic improvement in the anti-tumour efficiency of the nanoparticle in vitro and vivo. The multifunctional nanoparticle efficiently prevents the osteoclasia progression of OS xenograft bone tumors in vivo. Finally, this study provides guidance and a point of reference for clinical approaches to treating OS. |
| first_indexed | 2024-03-07T14:28:26Z |
| format | Article |
| id | doaj.art-efeaa68a2d504f8ea95d520106ebfe19 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-03-07T14:28:26Z |
| publishDate | 2024-06-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-efeaa68a2d504f8ea95d520106ebfe192024-03-06T05:28:26ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2024-06-0136157167A multifunctional biomimetic nanoplatform for image-guideded photothermal-ferroptotic synergistic osteosarcoma therapyYu-jie Liu0Su-he Dong1Wen-hao Hu2Qiao-ling Chen3Shao-fu Zhang4Kai Song5Zhen-chuan Han6Meng-meng Li7Zhi-tao Han8Wei-bo Liu9Xue-song Zhang10Department of Orthopedic Oncology and Spine Tumor Center, Changzheng Hospital, Second Military Medical University, Shanghai, 200001, ChinaPLA Rocket Force Characteristic Medical Center, Beijing, 100088, ChinaDepartment of Orthopaedics, The Fourth Medical Centre, Chinese PLA General Hospital, 51 Fucheng Road, Haidian District, Beijing, 100048, ChinaDepartment of Orthopaedics, The Fourth Medical Centre, Chinese PLA General Hospital, 51 Fucheng Road, Haidian District, Beijing, 100048, ChinaDepartment of Orthopaedics, The Fourth Medical Centre, Chinese PLA General Hospital, 51 Fucheng Road, Haidian District, Beijing, 100048, ChinaDepartment of Orthopaedics, The Fourth Medical Centre, Chinese PLA General Hospital, 51 Fucheng Road, Haidian District, Beijing, 100048, ChinaPLA Rocket Force Characteristic Medical Center, Beijing, 100088, ChinaDepartment of Anesthesiology, The Fourth Medical Centre, Chinese PLA General Hospital, 51 Fucheng Road, Haidian District, Beijing, 100048, China; Corresponding author.School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, 210023, Jiangsu, China; Corresponding authors.Department of Orthopaedics, The Fourth Medical Centre, Chinese PLA General Hospital, 51 Fucheng Road, Haidian District, Beijing, 100048, China; Corresponding author.Department of Orthopaedics, The Fourth Medical Centre, Chinese PLA General Hospital, 51 Fucheng Road, Haidian District, Beijing, 100048, China; Corresponding authors.Much effort has been devoted to improving treatment efficiency for osteosarcoma (OS). However, most current approaches result in poor therapeutic responses, thus indicating the need for the development of other therapeutic options. This study developed a multifunctional nanoparticle, PDA-MOF-E-M, an aggregation of OS targeting, programmed death targeting, and near-infrared (NIR)-aided targeting. At the same time, a multifunctional nanoparticle that utilises Fe-MOFs to create a cellular iron-rich environment and erastin as a ferroptosis inducer while ensuring targeted delivery to OS cells through cell membrane encapsulation is presented. The combination of PDA-MOF-E-M and PTT increased intracellular ROS and LPO levels and induced ferroptosis-related protein expression. A PDA-based PTT combined with erastin showed significant synergistic therapeutic improvement in the anti-tumour efficiency of the nanoparticle in vitro and vivo. The multifunctional nanoparticle efficiently prevents the osteoclasia progression of OS xenograft bone tumors in vivo. Finally, this study provides guidance and a point of reference for clinical approaches to treating OS.http://www.sciencedirect.com/science/article/pii/S2452199X24000525 |
| spellingShingle | Yu-jie Liu Su-he Dong Wen-hao Hu Qiao-ling Chen Shao-fu Zhang Kai Song Zhen-chuan Han Meng-meng Li Zhi-tao Han Wei-bo Liu Xue-song Zhang A multifunctional biomimetic nanoplatform for image-guideded photothermal-ferroptotic synergistic osteosarcoma therapy Bioactive Materials |
| title | A multifunctional biomimetic nanoplatform for image-guideded photothermal-ferroptotic synergistic osteosarcoma therapy |
| title_full | A multifunctional biomimetic nanoplatform for image-guideded photothermal-ferroptotic synergistic osteosarcoma therapy |
| title_fullStr | A multifunctional biomimetic nanoplatform for image-guideded photothermal-ferroptotic synergistic osteosarcoma therapy |
| title_full_unstemmed | A multifunctional biomimetic nanoplatform for image-guideded photothermal-ferroptotic synergistic osteosarcoma therapy |
| title_short | A multifunctional biomimetic nanoplatform for image-guideded photothermal-ferroptotic synergistic osteosarcoma therapy |
| title_sort | multifunctional biomimetic nanoplatform for image guideded photothermal ferroptotic synergistic osteosarcoma therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X24000525 |
| work_keys_str_mv | AT yujieliu amultifunctionalbiomimeticnanoplatformforimageguidededphotothermalferroptoticsynergisticosteosarcomatherapy AT suhedong amultifunctionalbiomimeticnanoplatformforimageguidededphotothermalferroptoticsynergisticosteosarcomatherapy AT wenhaohu amultifunctionalbiomimeticnanoplatformforimageguidededphotothermalferroptoticsynergisticosteosarcomatherapy AT qiaolingchen amultifunctionalbiomimeticnanoplatformforimageguidededphotothermalferroptoticsynergisticosteosarcomatherapy AT shaofuzhang amultifunctionalbiomimeticnanoplatformforimageguidededphotothermalferroptoticsynergisticosteosarcomatherapy AT kaisong amultifunctionalbiomimeticnanoplatformforimageguidededphotothermalferroptoticsynergisticosteosarcomatherapy AT zhenchuanhan amultifunctionalbiomimeticnanoplatformforimageguidededphotothermalferroptoticsynergisticosteosarcomatherapy AT mengmengli amultifunctionalbiomimeticnanoplatformforimageguidededphotothermalferroptoticsynergisticosteosarcomatherapy AT zhitaohan amultifunctionalbiomimeticnanoplatformforimageguidededphotothermalferroptoticsynergisticosteosarcomatherapy AT weiboliu amultifunctionalbiomimeticnanoplatformforimageguidededphotothermalferroptoticsynergisticosteosarcomatherapy AT xuesongzhang amultifunctionalbiomimeticnanoplatformforimageguidededphotothermalferroptoticsynergisticosteosarcomatherapy AT yujieliu multifunctionalbiomimeticnanoplatformforimageguidededphotothermalferroptoticsynergisticosteosarcomatherapy AT suhedong multifunctionalbiomimeticnanoplatformforimageguidededphotothermalferroptoticsynergisticosteosarcomatherapy AT wenhaohu multifunctionalbiomimeticnanoplatformforimageguidededphotothermalferroptoticsynergisticosteosarcomatherapy AT qiaolingchen multifunctionalbiomimeticnanoplatformforimageguidededphotothermalferroptoticsynergisticosteosarcomatherapy AT shaofuzhang multifunctionalbiomimeticnanoplatformforimageguidededphotothermalferroptoticsynergisticosteosarcomatherapy AT kaisong multifunctionalbiomimeticnanoplatformforimageguidededphotothermalferroptoticsynergisticosteosarcomatherapy AT zhenchuanhan multifunctionalbiomimeticnanoplatformforimageguidededphotothermalferroptoticsynergisticosteosarcomatherapy AT mengmengli multifunctionalbiomimeticnanoplatformforimageguidededphotothermalferroptoticsynergisticosteosarcomatherapy AT zhitaohan multifunctionalbiomimeticnanoplatformforimageguidededphotothermalferroptoticsynergisticosteosarcomatherapy AT weiboliu multifunctionalbiomimeticnanoplatformforimageguidededphotothermalferroptoticsynergisticosteosarcomatherapy AT xuesongzhang multifunctionalbiomimeticnanoplatformforimageguidededphotothermalferroptoticsynergisticosteosarcomatherapy |