Revealing a novel nociceptive network that links the subthalamic nucleus to pain processing
Pain is a prevalent symptom of Parkinson’s disease, and is effectively treated by deep brain stimulation of the subthalamic nucleus (STN). However, the link between pain and the STN remains unclear. In the present work, using in vivo electrophysiology in rats, we report that STN neurons exhibit comp...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2018-08-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/36607 |
| _version_ | 1811200789154103296 |
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| author | Arnaud Pautrat Marta Rolland Margaux Barthelemy Christelle Baunez Valérie Sinniger Brigitte Piallat Marc Savasta Paul G Overton Olivier David Veronique Coizet |
| author_facet | Arnaud Pautrat Marta Rolland Margaux Barthelemy Christelle Baunez Valérie Sinniger Brigitte Piallat Marc Savasta Paul G Overton Olivier David Veronique Coizet |
| author_sort | Arnaud Pautrat |
| collection | DOAJ |
| description | Pain is a prevalent symptom of Parkinson’s disease, and is effectively treated by deep brain stimulation of the subthalamic nucleus (STN). However, the link between pain and the STN remains unclear. In the present work, using in vivo electrophysiology in rats, we report that STN neurons exhibit complex tonic and phasic responses to noxious stimuli. We also show that nociception is altered following lesions of the STN, and characterize the role of the superior colliculus and the parabrachial nucleus in the transmission of nociceptive information to the STN, physiologically from both structures and anatomically in the case of the parabrachial nucleus. We show that STN nociceptive responses are abnormal in a rat model of PD, suggesting their dependence on the integrity of the nigrostriatal dopaminergic system. The STN-linked nociceptive network that we reveal is likely to be of considerable clinical importance in neurological diseases involving a dysfunction of the basal ganglia. |
| first_indexed | 2024-04-12T02:09:35Z |
| format | Article |
| id | doaj.art-efec03aca01349d2a004887e2f8e6b24 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:09:35Z |
| publishDate | 2018-08-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-efec03aca01349d2a004887e2f8e6b242022-12-22T03:52:27ZengeLife Sciences Publications LtdeLife2050-084X2018-08-01710.7554/eLife.36607Revealing a novel nociceptive network that links the subthalamic nucleus to pain processingArnaud Pautrat0Marta Rolland1Margaux Barthelemy2Christelle Baunez3https://orcid.org/0000-0002-4368-652XValérie Sinniger4Brigitte Piallat5Marc Savasta6Paul G Overton7Olivier David8Veronique Coizet9https://orcid.org/0000-0001-5192-6610Inserm, Grenoble, France; Grenoble Institute of Neurosciences, Université Grenoble Alpes, Grenoble, FranceInserm, Grenoble, France; Grenoble Institute of Neurosciences, Université Grenoble Alpes, Grenoble, FranceInserm, Grenoble, France; Grenoble Institute of Neurosciences, Université Grenoble Alpes, Grenoble, FranceInstitut de Neurosciences de la Timone, Aix-Marseille Université, Marseille, FranceGrenoble Institute of Neurosciences, Université Grenoble Alpes, Grenoble, France; Service d’Hépato-Gastroentérologie, CHU Grenoble Alpes, Grenoble, FranceInserm, Grenoble, France; Grenoble Institute of Neurosciences, Université Grenoble Alpes, Grenoble, FranceInserm, Grenoble, France; Grenoble Institute of Neurosciences, Université Grenoble Alpes, Grenoble, FranceDepartment of Psychology, University of Sheffield, Sheffield, United KingdomInserm, Grenoble, France; Grenoble Institute of Neurosciences, Université Grenoble Alpes, Grenoble, FranceInserm, Grenoble, France; Grenoble Institute of Neurosciences, Université Grenoble Alpes, Grenoble, FrancePain is a prevalent symptom of Parkinson’s disease, and is effectively treated by deep brain stimulation of the subthalamic nucleus (STN). However, the link between pain and the STN remains unclear. In the present work, using in vivo electrophysiology in rats, we report that STN neurons exhibit complex tonic and phasic responses to noxious stimuli. We also show that nociception is altered following lesions of the STN, and characterize the role of the superior colliculus and the parabrachial nucleus in the transmission of nociceptive information to the STN, physiologically from both structures and anatomically in the case of the parabrachial nucleus. We show that STN nociceptive responses are abnormal in a rat model of PD, suggesting their dependence on the integrity of the nigrostriatal dopaminergic system. The STN-linked nociceptive network that we reveal is likely to be of considerable clinical importance in neurological diseases involving a dysfunction of the basal ganglia.https://elifesciences.org/articles/36607subthalamic nucleuspain, nociceptive networksubcortical hyperdirect pathwayparabrachial nucleussuperior colliculus |
| spellingShingle | Arnaud Pautrat Marta Rolland Margaux Barthelemy Christelle Baunez Valérie Sinniger Brigitte Piallat Marc Savasta Paul G Overton Olivier David Veronique Coizet Revealing a novel nociceptive network that links the subthalamic nucleus to pain processing eLife subthalamic nucleus pain, nociceptive network subcortical hyperdirect pathway parabrachial nucleus superior colliculus |
| title | Revealing a novel nociceptive network that links the subthalamic nucleus to pain processing |
| title_full | Revealing a novel nociceptive network that links the subthalamic nucleus to pain processing |
| title_fullStr | Revealing a novel nociceptive network that links the subthalamic nucleus to pain processing |
| title_full_unstemmed | Revealing a novel nociceptive network that links the subthalamic nucleus to pain processing |
| title_short | Revealing a novel nociceptive network that links the subthalamic nucleus to pain processing |
| title_sort | revealing a novel nociceptive network that links the subthalamic nucleus to pain processing |
| topic | subthalamic nucleus pain, nociceptive network subcortical hyperdirect pathway parabrachial nucleus superior colliculus |
| url | https://elifesciences.org/articles/36607 |
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