A new toxic-free Ti40Zr10Co36Pd14 metallic glass with good biocompatibility and surface behaviour comparable to Ti-6Al-4V
In this study, a new toxic-free Ti40Zr10Co36Pd14 amorphous alloy with a critical casting size of 5 mm diameter and 20 mm long has been synthesised through copper-mold casting process. The Ti40Zr10Co36Pd14 bulk metallic glass (BMG) rod has further formed into thin films through the filtered cathodic...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Materials & Design |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127522003124 |
| _version_ | 1818239113219801088 |
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| author | Abdul Azeez Abdu Aliyu Suparat Udomlertpreecha Min Medhisuwakul Chinnapat Panwisawas Roger Reed Chedtha Puncreobutr Jirapon Khamwannah Surasak Kuimalee Chetarpa Yipyintum Boonrat Lohwongwatana |
| author_facet | Abdul Azeez Abdu Aliyu Suparat Udomlertpreecha Min Medhisuwakul Chinnapat Panwisawas Roger Reed Chedtha Puncreobutr Jirapon Khamwannah Surasak Kuimalee Chetarpa Yipyintum Boonrat Lohwongwatana |
| author_sort | Abdul Azeez Abdu Aliyu |
| collection | DOAJ |
| description | In this study, a new toxic-free Ti40Zr10Co36Pd14 amorphous alloy with a critical casting size of 5 mm diameter and 20 mm long has been synthesised through copper-mold casting process. The Ti40Zr10Co36Pd14 bulk metallic glass (BMG) rod has further formed into thin films through the filtered cathodic vacuum arc (FCVA) deposition process. To assess the biocompatibility and the surface behaviour of the synthesised Ti40Zr10Co36Pd14 BMG, the metallic glass (MG) thin films are fabricated on the glass substrate and cultured using murine osteoblast cells (MC3T3-E1) and human osteoblast-like cells (SaOS-2). Various characterisation techniques has been utilised to evaluate the surface properties and the cultured cells behaviour of the deposited thin films. The synthesised Ti40Zr10Co36Pd14 composition shows good biocompatibility similar to the routinely used Ti-6Al-4V. The osteoblast cells proliferate very well on the Ti40Zr10Co36Pd14 MGs and exhibit similar levels of alkaline phosphatase enzymatic activity to those of the controls and the Ti-6Al-4V material. The MC3T3-E1 cells adhered and spread faster on the alumina particle blasted Ti40Zr10Co36Pd14 and Ti-6Al-4V surfaces with osteoblast-like shapes. These results suggest that Ti40Zr10Co36Pd14 BMG is biocompatible and could support osteoblast differentiation. Thus, the new alloy can be used as a candidate material for potential biomedical application. |
| first_indexed | 2024-12-12T12:52:23Z |
| format | Article |
| id | doaj.art-efeeb35af8d6422298012606999efe7b |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-12-12T12:52:23Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-efeeb35af8d6422298012606999efe7b2022-12-22T00:23:58ZengElsevierMaterials & Design0264-12752022-06-01218110691A new toxic-free Ti40Zr10Co36Pd14 metallic glass with good biocompatibility and surface behaviour comparable to Ti-6Al-4VAbdul Azeez Abdu Aliyu0Suparat Udomlertpreecha1Min Medhisuwakul2Chinnapat Panwisawas3Roger Reed4Chedtha Puncreobutr5Jirapon Khamwannah6Surasak Kuimalee7Chetarpa Yipyintum8Boonrat Lohwongwatana9M3D Laboratory, Advanced Materials Analysis Research Unit, Department of Metallurgical Engineering, Faculty of Engineering, Chulalongkorn University, Phayathai Road, Pathumwan, Bangkok 10330, ThailandM3D Laboratory, Advanced Materials Analysis Research Unit, Department of Metallurgical Engineering, Faculty of Engineering, Chulalongkorn University, Phayathai Road, Pathumwan, Bangkok 10330, ThailandDepartment of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai, ThailandSchool of Engineering, University of Leicester, University Road, Leicester LE1 7RH, United KingdomDepartment of Materials, University of Oxford, Parks Road, Oxford OX1 3PH, United KingdomM3D Laboratory, Advanced Materials Analysis Research Unit, Department of Metallurgical Engineering, Faculty of Engineering, Chulalongkorn University, Phayathai Road, Pathumwan, Bangkok 10330, ThailandM3D Laboratory, Advanced Materials Analysis Research Unit, Department of Metallurgical Engineering, Faculty of Engineering, Chulalongkorn University, Phayathai Road, Pathumwan, Bangkok 10330, ThailandDepartment of Industrial Chemistry and Textile Technology, Maejo University, Chiang Mai, ThailandBiomechanics Research Center, Meticuly Co., Ltd, Chulalongkorn University, Bangkok, ThailandM3D Laboratory, Advanced Materials Analysis Research Unit, Department of Metallurgical Engineering, Faculty of Engineering, Chulalongkorn University, Phayathai Road, Pathumwan, Bangkok 10330, Thailand; Corresponding author.In this study, a new toxic-free Ti40Zr10Co36Pd14 amorphous alloy with a critical casting size of 5 mm diameter and 20 mm long has been synthesised through copper-mold casting process. The Ti40Zr10Co36Pd14 bulk metallic glass (BMG) rod has further formed into thin films through the filtered cathodic vacuum arc (FCVA) deposition process. To assess the biocompatibility and the surface behaviour of the synthesised Ti40Zr10Co36Pd14 BMG, the metallic glass (MG) thin films are fabricated on the glass substrate and cultured using murine osteoblast cells (MC3T3-E1) and human osteoblast-like cells (SaOS-2). Various characterisation techniques has been utilised to evaluate the surface properties and the cultured cells behaviour of the deposited thin films. The synthesised Ti40Zr10Co36Pd14 composition shows good biocompatibility similar to the routinely used Ti-6Al-4V. The osteoblast cells proliferate very well on the Ti40Zr10Co36Pd14 MGs and exhibit similar levels of alkaline phosphatase enzymatic activity to those of the controls and the Ti-6Al-4V material. The MC3T3-E1 cells adhered and spread faster on the alumina particle blasted Ti40Zr10Co36Pd14 and Ti-6Al-4V surfaces with osteoblast-like shapes. These results suggest that Ti40Zr10Co36Pd14 BMG is biocompatible and could support osteoblast differentiation. Thus, the new alloy can be used as a candidate material for potential biomedical application.http://www.sciencedirect.com/science/article/pii/S0264127522003124Bulk metallic glassBiocompatibilityCopper-mold castingCell cultureSurface roughnessSandblasting |
| spellingShingle | Abdul Azeez Abdu Aliyu Suparat Udomlertpreecha Min Medhisuwakul Chinnapat Panwisawas Roger Reed Chedtha Puncreobutr Jirapon Khamwannah Surasak Kuimalee Chetarpa Yipyintum Boonrat Lohwongwatana A new toxic-free Ti40Zr10Co36Pd14 metallic glass with good biocompatibility and surface behaviour comparable to Ti-6Al-4V Materials & Design Bulk metallic glass Biocompatibility Copper-mold casting Cell culture Surface roughness Sandblasting |
| title | A new toxic-free Ti40Zr10Co36Pd14 metallic glass with good biocompatibility and surface behaviour comparable to Ti-6Al-4V |
| title_full | A new toxic-free Ti40Zr10Co36Pd14 metallic glass with good biocompatibility and surface behaviour comparable to Ti-6Al-4V |
| title_fullStr | A new toxic-free Ti40Zr10Co36Pd14 metallic glass with good biocompatibility and surface behaviour comparable to Ti-6Al-4V |
| title_full_unstemmed | A new toxic-free Ti40Zr10Co36Pd14 metallic glass with good biocompatibility and surface behaviour comparable to Ti-6Al-4V |
| title_short | A new toxic-free Ti40Zr10Co36Pd14 metallic glass with good biocompatibility and surface behaviour comparable to Ti-6Al-4V |
| title_sort | new toxic free ti40zr10co36pd14 metallic glass with good biocompatibility and surface behaviour comparable to ti 6al 4v |
| topic | Bulk metallic glass Biocompatibility Copper-mold casting Cell culture Surface roughness Sandblasting |
| url | http://www.sciencedirect.com/science/article/pii/S0264127522003124 |
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