Scalable Electrophysiology of Millimeter-Scale Animals with Electrode Devices
Millimeter-scale animals such as Caenorhabditis elegans, Drosophila larvae, zebrafish, and bees serve as powerful model organisms in the fields of neurobiology and neuroethology. Various methods exist for recording large-scale electrophysiological signals from these animals. Existing approaches ofte...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Association for the Advancement of Science (AAAS)
2023-01-01
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| Series: | BME Frontiers |
| Online Access: | https://spj.science.org/doi/10.34133/bmef.0034 |
| _version_ | 1797225112541331456 |
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| author | Kairu Dong Wen-Che Liu Yuyan Su Yidan Lyu Hao Huang Nenggan Zheng John A. Rogers Kewang Nan |
| author_facet | Kairu Dong Wen-Che Liu Yuyan Su Yidan Lyu Hao Huang Nenggan Zheng John A. Rogers Kewang Nan |
| author_sort | Kairu Dong |
| collection | DOAJ |
| description | Millimeter-scale animals such as Caenorhabditis elegans, Drosophila larvae, zebrafish, and bees serve as powerful model organisms in the fields of neurobiology and neuroethology. Various methods exist for recording large-scale electrophysiological signals from these animals. Existing approaches often lack, however, real-time, uninterrupted investigations due to their rigid constructs, geometric constraints, and mechanical mismatch in integration with soft organisms. The recent research establishes the foundations for 3-dimensional flexible bioelectronic interfaces that incorporate microfabricated components and nanoelectronic function with adjustable mechanical properties and multidimensional variability, offering unique capabilities for chronic, stable interrogation and stimulation of millimeter-scale animals and miniature tissue constructs. This review summarizes the most advanced technologies for electrophysiological studies, based on methods of 3-dimensional flexible bioelectronics. A concluding section addresses the challenges of these devices in achieving freestanding, robust, and multifunctional biointerfaces. |
| first_indexed | 2024-03-09T01:37:41Z |
| format | Article |
| id | doaj.art-efeecb5d733b4ee8a8b7fb31e6e118e0 |
| institution | Directory Open Access Journal |
| issn | 2765-8031 |
| language | English |
| last_indexed | 2024-04-24T14:03:50Z |
| publishDate | 2023-01-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | BME Frontiers |
| spelling | doaj.art-efeecb5d733b4ee8a8b7fb31e6e118e02024-04-03T10:57:13ZengAmerican Association for the Advancement of Science (AAAS)BME Frontiers2765-80312023-01-01410.34133/bmef.0034Scalable Electrophysiology of Millimeter-Scale Animals with Electrode DevicesKairu Dong0Wen-Che Liu1Yuyan Su2Yidan Lyu3Hao Huang4Nenggan Zheng5John A. Rogers6Kewang Nan7College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou 310027, China.Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.Millimeter-scale animals such as Caenorhabditis elegans, Drosophila larvae, zebrafish, and bees serve as powerful model organisms in the fields of neurobiology and neuroethology. Various methods exist for recording large-scale electrophysiological signals from these animals. Existing approaches often lack, however, real-time, uninterrupted investigations due to their rigid constructs, geometric constraints, and mechanical mismatch in integration with soft organisms. The recent research establishes the foundations for 3-dimensional flexible bioelectronic interfaces that incorporate microfabricated components and nanoelectronic function with adjustable mechanical properties and multidimensional variability, offering unique capabilities for chronic, stable interrogation and stimulation of millimeter-scale animals and miniature tissue constructs. This review summarizes the most advanced technologies for electrophysiological studies, based on methods of 3-dimensional flexible bioelectronics. A concluding section addresses the challenges of these devices in achieving freestanding, robust, and multifunctional biointerfaces.https://spj.science.org/doi/10.34133/bmef.0034 |
| spellingShingle | Kairu Dong Wen-Che Liu Yuyan Su Yidan Lyu Hao Huang Nenggan Zheng John A. Rogers Kewang Nan Scalable Electrophysiology of Millimeter-Scale Animals with Electrode Devices BME Frontiers |
| title | Scalable Electrophysiology of Millimeter-Scale Animals with Electrode Devices |
| title_full | Scalable Electrophysiology of Millimeter-Scale Animals with Electrode Devices |
| title_fullStr | Scalable Electrophysiology of Millimeter-Scale Animals with Electrode Devices |
| title_full_unstemmed | Scalable Electrophysiology of Millimeter-Scale Animals with Electrode Devices |
| title_short | Scalable Electrophysiology of Millimeter-Scale Animals with Electrode Devices |
| title_sort | scalable electrophysiology of millimeter scale animals with electrode devices |
| url | https://spj.science.org/doi/10.34133/bmef.0034 |
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