p53 expression as a prognostic marker in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most frequent cancers worldwide with a high mortality. Immunohistochemical overexpression of the p53 protein was correlated with a poor prognosis in various human malignancies, including HCC. In our study, 45 resected HCCs were examined to evalua...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
University of Belgrade, University of Novi Sad
2014-01-01
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| Series: | Archives of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641402841C.pdf |
| Summary: | Hepatocellular carcinoma (HCC) is one of the most frequent cancers worldwide
with a high mortality. Immunohistochemical overexpression of the p53 protein
was correlated with a poor prognosis in various human malignancies, including
HCC. In our study, 45 resected HCCs were examined to evaluate the expression
of p53 and its correlation with clinicopathological parameters.
Immunohistochemical detection of p53 with monoclonal human antibody, revealed
its overexpression in 20 tumors (44%), including diffuse positive in 7 cases
(35%), heterogeneous in 5 (25%), and focal in 8 (40%). We considered a
positive reaction only in the presence of immunostained nuclei in brown
shades in more than 5% of the tumor nuclei. To elucidate the significance of
p53 in HCC, we correlated its protein expression with major
clinicopathological features. We did not observe significant correlation with
sex, age, presence of cirrhosis, chronic hepatitis status, tumoral necrosis
and tumor size. The density and intensity of p53 revealed significant
correlation with histological grade (P=0.008 and P=0.014) and tumor stage
(P=0.005 and P=0.007). In conclusion, our results suggest that overexpression
of p53 is associated with HCC progression and contributes to disease
progression. Moreover, p53 expression may be a valuable marker of HCC
prognosis. |
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| ISSN: | 0354-4664 1821-4339 |