p53 expression as a prognostic marker in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most frequent cancers worldwide with a high mortality. Immunohistochemical overexpression of the p53 protein was correlated with a poor prognosis in various human malignancies, including HCC. In our study, 45 resected HCCs were examined to evalua...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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University of Belgrade, University of Novi Sad
2014-01-01
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| Series: | Archives of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641402841C.pdf |
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| author | Cioca Andreea Cimpean Maria Anca Kundnani Nilima Rajpal Ceausu Raluca Suciu Cristian Raica Marius |
| author_facet | Cioca Andreea Cimpean Maria Anca Kundnani Nilima Rajpal Ceausu Raluca Suciu Cristian Raica Marius |
| author_sort | Cioca Andreea |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is one of the most frequent cancers worldwide
with a high mortality. Immunohistochemical overexpression of the p53 protein
was correlated with a poor prognosis in various human malignancies, including
HCC. In our study, 45 resected HCCs were examined to evaluate the expression
of p53 and its correlation with clinicopathological parameters.
Immunohistochemical detection of p53 with monoclonal human antibody, revealed
its overexpression in 20 tumors (44%), including diffuse positive in 7 cases
(35%), heterogeneous in 5 (25%), and focal in 8 (40%). We considered a
positive reaction only in the presence of immunostained nuclei in brown
shades in more than 5% of the tumor nuclei. To elucidate the significance of
p53 in HCC, we correlated its protein expression with major
clinicopathological features. We did not observe significant correlation with
sex, age, presence of cirrhosis, chronic hepatitis status, tumoral necrosis
and tumor size. The density and intensity of p53 revealed significant
correlation with histological grade (P=0.008 and P=0.014) and tumor stage
(P=0.005 and P=0.007). In conclusion, our results suggest that overexpression
of p53 is associated with HCC progression and contributes to disease
progression. Moreover, p53 expression may be a valuable marker of HCC
prognosis. |
| first_indexed | 2024-12-19T10:20:29Z |
| format | Article |
| id | doaj.art-efef17fe1b1142f696f37007142395da |
| institution | Directory Open Access Journal |
| issn | 0354-4664 1821-4339 |
| language | English |
| last_indexed | 2024-12-19T10:20:29Z |
| publishDate | 2014-01-01 |
| publisher | University of Belgrade, University of Novi Sad |
| record_format | Article |
| series | Archives of Biological Sciences |
| spelling | doaj.art-efef17fe1b1142f696f37007142395da2022-12-21T20:26:05ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46641821-43392014-01-0166284184510.2298/ABS1402841C0354-46641402841Cp53 expression as a prognostic marker in hepatocellular carcinomaCioca Andreea0Cimpean Maria Anca1Kundnani Nilima Rajpal2Ceausu Raluca3Suciu Cristian4Raica Marius5“Iuliu Hatieganu” University of Medicine and Pharmacy, Department of Pathology, Cluj-Napoca, RomaniaUniversity of Medicine and Pharmacy, Angiogenesis Research Center, Timisoara, RomaniaUniversity of Medicine and Pharmacy, Angiogenesis Research Center, Timisoara, RomaniaUniversity of Medicine and Pharmacy, Angiogenesis Research Center, Timisoara, RomaniaUniversity of Medicine and Pharmacy, Angiogenesis Research Center, Timisoara, RomaniaUniversity of Medicine and Pharmacy, Angiogenesis Research Center, Timisoara, RomaniaHepatocellular carcinoma (HCC) is one of the most frequent cancers worldwide with a high mortality. Immunohistochemical overexpression of the p53 protein was correlated with a poor prognosis in various human malignancies, including HCC. In our study, 45 resected HCCs were examined to evaluate the expression of p53 and its correlation with clinicopathological parameters. Immunohistochemical detection of p53 with monoclonal human antibody, revealed its overexpression in 20 tumors (44%), including diffuse positive in 7 cases (35%), heterogeneous in 5 (25%), and focal in 8 (40%). We considered a positive reaction only in the presence of immunostained nuclei in brown shades in more than 5% of the tumor nuclei. To elucidate the significance of p53 in HCC, we correlated its protein expression with major clinicopathological features. We did not observe significant correlation with sex, age, presence of cirrhosis, chronic hepatitis status, tumoral necrosis and tumor size. The density and intensity of p53 revealed significant correlation with histological grade (P=0.008 and P=0.014) and tumor stage (P=0.005 and P=0.007). In conclusion, our results suggest that overexpression of p53 is associated with HCC progression and contributes to disease progression. Moreover, p53 expression may be a valuable marker of HCC prognosis.http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641402841C.pdfp53hepatocellular carcinomaprognosisoverexpression |
| spellingShingle | Cioca Andreea Cimpean Maria Anca Kundnani Nilima Rajpal Ceausu Raluca Suciu Cristian Raica Marius p53 expression as a prognostic marker in hepatocellular carcinoma Archives of Biological Sciences p53 hepatocellular carcinoma prognosis overexpression |
| title | p53 expression as a prognostic marker in hepatocellular carcinoma |
| title_full | p53 expression as a prognostic marker in hepatocellular carcinoma |
| title_fullStr | p53 expression as a prognostic marker in hepatocellular carcinoma |
| title_full_unstemmed | p53 expression as a prognostic marker in hepatocellular carcinoma |
| title_short | p53 expression as a prognostic marker in hepatocellular carcinoma |
| title_sort | p53 expression as a prognostic marker in hepatocellular carcinoma |
| topic | p53 hepatocellular carcinoma prognosis overexpression |
| url | http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641402841C.pdf |
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