Th1-related transcription factors and cytokines in systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is an inflammatory disorder related to immunity dysfunction. The Th1 cell family including Th1 cells, transcription factor T-bet, and related cytokines IFNγ, TNFα, IL-2, IL-18, TGF-β, and IL-12 have been widely discussed in autoimmunity, such as SLE. In this review...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1305590/full |
| _version_ | 1797387835193425920 |
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| author | Yang-Yang Tang Da-Cheng Wang You-Yue Chen Wang-Dong Xu An-Fang Huang |
| author_facet | Yang-Yang Tang Da-Cheng Wang You-Yue Chen Wang-Dong Xu An-Fang Huang |
| author_sort | Yang-Yang Tang |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is an inflammatory disorder related to immunity dysfunction. The Th1 cell family including Th1 cells, transcription factor T-bet, and related cytokines IFNγ, TNFα, IL-2, IL-18, TGF-β, and IL-12 have been widely discussed in autoimmunity, such as SLE. In this review, we will comprehensively discuss the expression profile of the Th1 cell family in both SLE patients and animal models and clarify how the family members are involved in lupus development. Interestingly, T-bet-related age-associated B cells (ABCs) and low-dose IL-2 treatment in lupus were emergently discussed as well. Collection of the evidence will better understand the roles of the Th1 cell family in lupus pathogenesis, especially targeting IL-2 in lupus. |
| first_indexed | 2024-03-08T22:30:53Z |
| format | Article |
| id | doaj.art-eff1f6da240d45cdb34e1449c8bae7ce |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T22:30:53Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-eff1f6da240d45cdb34e1449c8bae7ce2023-12-18T04:55:43ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-12-011410.3389/fimmu.2023.13055901305590Th1-related transcription factors and cytokines in systemic lupus erythematosusYang-Yang Tang0Da-Cheng Wang1You-Yue Chen2Wang-Dong Xu3An-Fang Huang4Department of Evidence-Based Medicine, Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Evidence-Based Medicine, Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Evidence-Based Medicine, Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Evidence-Based Medicine, Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Rheumatology and Immunology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaSystemic lupus erythematosus (SLE) is an inflammatory disorder related to immunity dysfunction. The Th1 cell family including Th1 cells, transcription factor T-bet, and related cytokines IFNγ, TNFα, IL-2, IL-18, TGF-β, and IL-12 have been widely discussed in autoimmunity, such as SLE. In this review, we will comprehensively discuss the expression profile of the Th1 cell family in both SLE patients and animal models and clarify how the family members are involved in lupus development. Interestingly, T-bet-related age-associated B cells (ABCs) and low-dose IL-2 treatment in lupus were emergently discussed as well. Collection of the evidence will better understand the roles of the Th1 cell family in lupus pathogenesis, especially targeting IL-2 in lupus.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1305590/fullTh1 cellT-betIL-2lupusinflammatory cytokines |
| spellingShingle | Yang-Yang Tang Da-Cheng Wang You-Yue Chen Wang-Dong Xu An-Fang Huang Th1-related transcription factors and cytokines in systemic lupus erythematosus Frontiers in Immunology Th1 cell T-bet IL-2 lupus inflammatory cytokines |
| title | Th1-related transcription factors and cytokines in systemic lupus erythematosus |
| title_full | Th1-related transcription factors and cytokines in systemic lupus erythematosus |
| title_fullStr | Th1-related transcription factors and cytokines in systemic lupus erythematosus |
| title_full_unstemmed | Th1-related transcription factors and cytokines in systemic lupus erythematosus |
| title_short | Th1-related transcription factors and cytokines in systemic lupus erythematosus |
| title_sort | th1 related transcription factors and cytokines in systemic lupus erythematosus |
| topic | Th1 cell T-bet IL-2 lupus inflammatory cytokines |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1305590/full |
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