Efficacy of Tuberculosis Treatment in Patients with Drug-Resistant Tuberculosis with the Use of Bedaquiline: The Experience of the Russian Federation
In the conditions of the continued growth of multiple- and extensive drug-resistant tuberculosis, use of the new highly effective anti-tuberculosis drugs in this patient category is of great relevance. The aim of the study was determination the efficacy of treatment in patients with multidrug- and e...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/11/11/1622 |
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| author | Anna Starshinova Irina Dovgalyk Ekaterina Belyaeva Anzhela Glushkova Nikolay Osipov Dmitry Kudlay |
| author_facet | Anna Starshinova Irina Dovgalyk Ekaterina Belyaeva Anzhela Glushkova Nikolay Osipov Dmitry Kudlay |
| author_sort | Anna Starshinova |
| collection | DOAJ |
| description | In the conditions of the continued growth of multiple- and extensive drug-resistant tuberculosis, use of the new highly effective anti-tuberculosis drugs in this patient category is of great relevance. The aim of the study was determination the efficacy of treatment in patients with multidrug- and extensive drug-resistant tuberculosis using bedaquiline based on studies published in the Russian Federation. Materials and methods: The authors analyzed data published in studies from 2014 to 2022; 41 publications were included in total and 17 articles corresponded to the study design. The results of treatment of 1404 tuberculosis patients with MDR/XDR TB were described. Bedaquiline was used according to the standard scheme with a description of the treatment results after 24–26 weeks. Treatment efficacy was estimated according to accepted criteria. Results of the study: The analysis showed that the treatment efficacy on conversion was achieved in 79.5% of cases (95% Cl 76.5–82.3), and recovery was observed in 82.0% of cases (95% Cl 78.6–85.1). Departure from the therapy was observed in rare cases (9.8%; 95% Cl 7.9–12.2). Deaths were recorded in 6.5% of cases (95% Cl 4.9–8.3), which were associated with the severe disease and concomitant pathology in 74.3%. The development of adverse events was noted in half of the patients (55.7%); however, bedaquiline cancellation occurred in a few cases (7.0%; 95% Cl 3.0–13.0). From analyzing data in patients with MDR and XDR TB, the efficacy of treatment was 89.9% (95% Cl 85.9–93.2) and 71.9% (95% Cl 66.2–77.1), respectively. Conclusion: Use of bedaquiline in treatment makes it possible to achieve recovery of patients with MDR/XDR TB in 82.0% of cases with patients dropping out of treatment in 9.8%. At the same time, in patients with MDR TB, recovery was achieved in 89.9% of cases, while in patients with XDR TB, 71.9% of cases recovered. |
| first_indexed | 2024-03-09T18:31:46Z |
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| id | doaj.art-eff2074d6a9c44608fc83e1a4d27048f |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T18:31:46Z |
| publishDate | 2022-11-01 |
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| series | Antibiotics |
| spelling | doaj.art-eff2074d6a9c44608fc83e1a4d27048f2023-11-24T07:30:48ZengMDPI AGAntibiotics2079-63822022-11-011111162210.3390/antibiotics11111622Efficacy of Tuberculosis Treatment in Patients with Drug-Resistant Tuberculosis with the Use of Bedaquiline: The Experience of the Russian FederationAnna Starshinova0Irina Dovgalyk1Ekaterina Belyaeva2Anzhela Glushkova3Nikolay Osipov4Dmitry Kudlay5Almazov National Medical Research Centre, 197341 Saint-Petersburg, RussiaSt. Petersburg Research Institute of Phthisiopulmonology, 191036 Saint-Petersburg, RussiaRepublic TB Healthcare Dispensary, 185032 Petrozavodsk, RussiaV.M. Bekhterev National Research Medical Center for Psychiatry and Neurology, 192019 Saint-Petersburg, RussiaSt. Petersburg Department of Steklov Mathematical Institute of Russian Academy of Sciences, 191023 Saint-Petersburg, RussiaFederal State Autonomous Educational Institution of Higher Education “First Moscow State Medical University Named after I.I. THEM. Sechenov” of the Ministry of Health of Russia (Sechenov University), St. Trubetskaya 8, Building 2, 119048 Moscow, RussiaIn the conditions of the continued growth of multiple- and extensive drug-resistant tuberculosis, use of the new highly effective anti-tuberculosis drugs in this patient category is of great relevance. The aim of the study was determination the efficacy of treatment in patients with multidrug- and extensive drug-resistant tuberculosis using bedaquiline based on studies published in the Russian Federation. Materials and methods: The authors analyzed data published in studies from 2014 to 2022; 41 publications were included in total and 17 articles corresponded to the study design. The results of treatment of 1404 tuberculosis patients with MDR/XDR TB were described. Bedaquiline was used according to the standard scheme with a description of the treatment results after 24–26 weeks. Treatment efficacy was estimated according to accepted criteria. Results of the study: The analysis showed that the treatment efficacy on conversion was achieved in 79.5% of cases (95% Cl 76.5–82.3), and recovery was observed in 82.0% of cases (95% Cl 78.6–85.1). Departure from the therapy was observed in rare cases (9.8%; 95% Cl 7.9–12.2). Deaths were recorded in 6.5% of cases (95% Cl 4.9–8.3), which were associated with the severe disease and concomitant pathology in 74.3%. The development of adverse events was noted in half of the patients (55.7%); however, bedaquiline cancellation occurred in a few cases (7.0%; 95% Cl 3.0–13.0). From analyzing data in patients with MDR and XDR TB, the efficacy of treatment was 89.9% (95% Cl 85.9–93.2) and 71.9% (95% Cl 66.2–77.1), respectively. Conclusion: Use of bedaquiline in treatment makes it possible to achieve recovery of patients with MDR/XDR TB in 82.0% of cases with patients dropping out of treatment in 9.8%. At the same time, in patients with MDR TB, recovery was achieved in 89.9% of cases, while in patients with XDR TB, 71.9% of cases recovered.https://www.mdpi.com/2079-6382/11/11/1622tuberculosisbedaquilinetreatment efficacymultidrug resistanceextensive drug resistancemycobacterium tuberculosis |
| spellingShingle | Anna Starshinova Irina Dovgalyk Ekaterina Belyaeva Anzhela Glushkova Nikolay Osipov Dmitry Kudlay Efficacy of Tuberculosis Treatment in Patients with Drug-Resistant Tuberculosis with the Use of Bedaquiline: The Experience of the Russian Federation Antibiotics tuberculosis bedaquiline treatment efficacy multidrug resistance extensive drug resistance mycobacterium tuberculosis |
| title | Efficacy of Tuberculosis Treatment in Patients with Drug-Resistant Tuberculosis with the Use of Bedaquiline: The Experience of the Russian Federation |
| title_full | Efficacy of Tuberculosis Treatment in Patients with Drug-Resistant Tuberculosis with the Use of Bedaquiline: The Experience of the Russian Federation |
| title_fullStr | Efficacy of Tuberculosis Treatment in Patients with Drug-Resistant Tuberculosis with the Use of Bedaquiline: The Experience of the Russian Federation |
| title_full_unstemmed | Efficacy of Tuberculosis Treatment in Patients with Drug-Resistant Tuberculosis with the Use of Bedaquiline: The Experience of the Russian Federation |
| title_short | Efficacy of Tuberculosis Treatment in Patients with Drug-Resistant Tuberculosis with the Use of Bedaquiline: The Experience of the Russian Federation |
| title_sort | efficacy of tuberculosis treatment in patients with drug resistant tuberculosis with the use of bedaquiline the experience of the russian federation |
| topic | tuberculosis bedaquiline treatment efficacy multidrug resistance extensive drug resistance mycobacterium tuberculosis |
| url | https://www.mdpi.com/2079-6382/11/11/1622 |
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