High occurrence of transportation and logistics occupations among vascular dementia patients: an observational study
Abstract Background Growing evidence suggests a role of occupation in the emergence and manifestation of dementia. Occupations are often defined by complexity level, although working environments and activities differ in several other important ways. We aimed to capture the multi-faceted nature of o...
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| Format: | Article |
| Language: | English |
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BMC
2019-12-01
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| Series: | Alzheimer’s Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13195-019-0570-4 |
| _version_ | 1818611514812137472 |
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| author | A. C. van Loenhoud C. de Boer K. Wols Y. A. Pijnenburg A. W. Lemstra F. H. Bouwman N. D. Prins P. Scheltens R. Ossenkoppele W. M. van der Flier |
| author_facet | A. C. van Loenhoud C. de Boer K. Wols Y. A. Pijnenburg A. W. Lemstra F. H. Bouwman N. D. Prins P. Scheltens R. Ossenkoppele W. M. van der Flier |
| author_sort | A. C. van Loenhoud |
| collection | DOAJ |
| description | Abstract Background Growing evidence suggests a role of occupation in the emergence and manifestation of dementia. Occupations are often defined by complexity level, although working environments and activities differ in several other important ways. We aimed to capture the multi-faceted nature of occupation through its measurement as a qualitative (instead of a quantitative) variable and explored its relationship with different types of dementia. Methods We collected occupational information of 2121 dementia patients with various suspected etiologies from the Amsterdam Dementia Cohort (age 67 ± 8, 57% male; MMSE 21 ± 5). Our final sample included individuals with Alzheimer’s disease (AD) dementia (n = 1467), frontotemporal dementia (n = 281), vascular dementia (n = 98), Lewy body disease (n = 174), and progressive supranuclear palsy/corticobasal degeneration (n = 101). Within the AD group, we used neuropsychological data to further characterize patients by clinical phenotypes. All participants were categorized into 1 of 11 occupational classes, across which we evaluated the distribution of dementia (sub)types with χ 2 analyses. We gained further insight into occupation-dementia relationships through post hoc logistic regressions that included various demographic and health characteristics as explanatory variables. Results There were significant differences in the distribution of dementia types across occupation groups (χ 2 = 85.87, p < .001). Vascular dementia was relatively common in the Transportation/Logistics sector, and higher vascular risk factors partly explained this relationship. AD occurred less in Transportation/Logistics and more in Health Care/Welfare occupations, which related to a higher/lower percentage of males. We found no relationships between occupational classes and clinical phenotypes of AD (χ 2 = 53.65, n.s.). Conclusions Relationships between occupation and dementia seem to exist beyond the complexity level, which offers new opportunities for disease prevention and improvement of occupational health policy. |
| first_indexed | 2024-12-16T15:31:33Z |
| format | Article |
| id | doaj.art-eff6e522663e4594809cd378cf1eff7a |
| institution | Directory Open Access Journal |
| issn | 1758-9193 |
| language | English |
| last_indexed | 2024-12-16T15:31:33Z |
| publishDate | 2019-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Alzheimer’s Research & Therapy |
| spelling | doaj.art-eff6e522663e4594809cd378cf1eff7a2022-12-21T22:26:21ZengBMCAlzheimer’s Research & Therapy1758-91932019-12-0111111110.1186/s13195-019-0570-4High occurrence of transportation and logistics occupations among vascular dementia patients: an observational studyA. C. van Loenhoud0C. de Boer1K. Wols2Y. A. Pijnenburg3A. W. Lemstra4F. H. Bouwman5N. D. Prins6P. Scheltens7R. Ossenkoppele8W. M. van der Flier9Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMCDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMCDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMCDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMCDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMCDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMCDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMCDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMCDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMCDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMCAbstract Background Growing evidence suggests a role of occupation in the emergence and manifestation of dementia. Occupations are often defined by complexity level, although working environments and activities differ in several other important ways. We aimed to capture the multi-faceted nature of occupation through its measurement as a qualitative (instead of a quantitative) variable and explored its relationship with different types of dementia. Methods We collected occupational information of 2121 dementia patients with various suspected etiologies from the Amsterdam Dementia Cohort (age 67 ± 8, 57% male; MMSE 21 ± 5). Our final sample included individuals with Alzheimer’s disease (AD) dementia (n = 1467), frontotemporal dementia (n = 281), vascular dementia (n = 98), Lewy body disease (n = 174), and progressive supranuclear palsy/corticobasal degeneration (n = 101). Within the AD group, we used neuropsychological data to further characterize patients by clinical phenotypes. All participants were categorized into 1 of 11 occupational classes, across which we evaluated the distribution of dementia (sub)types with χ 2 analyses. We gained further insight into occupation-dementia relationships through post hoc logistic regressions that included various demographic and health characteristics as explanatory variables. Results There were significant differences in the distribution of dementia types across occupation groups (χ 2 = 85.87, p < .001). Vascular dementia was relatively common in the Transportation/Logistics sector, and higher vascular risk factors partly explained this relationship. AD occurred less in Transportation/Logistics and more in Health Care/Welfare occupations, which related to a higher/lower percentage of males. We found no relationships between occupational classes and clinical phenotypes of AD (χ 2 = 53.65, n.s.). Conclusions Relationships between occupation and dementia seem to exist beyond the complexity level, which offers new opportunities for disease prevention and improvement of occupational health policy.https://doi.org/10.1186/s13195-019-0570-4OccupationVascular dementiaAlzheimer’s diseaseVascular risk factorsSex |
| spellingShingle | A. C. van Loenhoud C. de Boer K. Wols Y. A. Pijnenburg A. W. Lemstra F. H. Bouwman N. D. Prins P. Scheltens R. Ossenkoppele W. M. van der Flier High occurrence of transportation and logistics occupations among vascular dementia patients: an observational study Alzheimer’s Research & Therapy Occupation Vascular dementia Alzheimer’s disease Vascular risk factors Sex |
| title | High occurrence of transportation and logistics occupations among vascular dementia patients: an observational study |
| title_full | High occurrence of transportation and logistics occupations among vascular dementia patients: an observational study |
| title_fullStr | High occurrence of transportation and logistics occupations among vascular dementia patients: an observational study |
| title_full_unstemmed | High occurrence of transportation and logistics occupations among vascular dementia patients: an observational study |
| title_short | High occurrence of transportation and logistics occupations among vascular dementia patients: an observational study |
| title_sort | high occurrence of transportation and logistics occupations among vascular dementia patients an observational study |
| topic | Occupation Vascular dementia Alzheimer’s disease Vascular risk factors Sex |
| url | https://doi.org/10.1186/s13195-019-0570-4 |
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