Relationship between maternal and/or newborn cholesterol levels and neonatal septicemia: protocol for a Ugandan cohort of mother-newborn pairs
Abstract Background Many aspects of microbial dissemination appear to vary with host cholesterol levels. Since neonatal septicemia remains a leading cause of newborn admissions and mortality in resource-limited settings, the contribution of abnormal cholesterol levels in maternal and/or newborn bloo...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-07-01
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| Series: | BMC Pediatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12887-022-03494-w |
| _version_ | 1818509991851589632 |
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| author | Kenneth Ssebambulidde Anthony Kayiira Ivan Segawa Sylvia Namanda Victoria Nakibuuka Victor Musiime Theresa H. Ward |
| author_facet | Kenneth Ssebambulidde Anthony Kayiira Ivan Segawa Sylvia Namanda Victoria Nakibuuka Victor Musiime Theresa H. Ward |
| author_sort | Kenneth Ssebambulidde |
| collection | DOAJ |
| description | Abstract Background Many aspects of microbial dissemination appear to vary with host cholesterol levels. Since neonatal septicemia remains a leading cause of newborn admissions and mortality in resource-limited settings, the contribution of abnormal cholesterol levels in maternal and/or newborn blood to the risk of neonatal septicemia and outcome requires elucidation. We aim to determine a relationship between maternal serum and neonatal cord blood cholesterol levels and neonatal septicemia. Methods This will be a mother-newborn pair cohort study. Approximately 353 pregnant women who are eligible and consent to participate in the study will have blood drawn for a lipid profile. Upon delivery, we will analyse the cord blood cholesterol of their newborns and follow them for 28 days to determine whether the infants develop clinical signs and symptoms suggestive of neonatal septicemia. Relative risk will be used to determine the association between cholesterol and newborn septicemia. Poisson regression will be used to estimate the relative risk (with 95% confidence intervals) of developing septicemia. Discussion Findings from our study will contribute evidence to support the inclusion of lipid profile screening for pregnant women and newborns. Our study will determine whether newborns with abnormal cholesterol or those born to mothers with abnormal cholesterol will require rigorous follow-up in neonatal clinics. |
| first_indexed | 2024-12-10T22:53:02Z |
| format | Article |
| id | doaj.art-eff8db37579a4c2cb4a4cc2bf284b4b9 |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-12-10T22:53:02Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj.art-eff8db37579a4c2cb4a4cc2bf284b4b92022-12-22T01:30:21ZengBMCBMC Pediatrics1471-24312022-07-012211610.1186/s12887-022-03494-wRelationship between maternal and/or newborn cholesterol levels and neonatal septicemia: protocol for a Ugandan cohort of mother-newborn pairsKenneth Ssebambulidde0Anthony Kayiira1Ivan Segawa2Sylvia Namanda3Victoria Nakibuuka4Victor Musiime5Theresa H. Ward6Research Department, Infectious Diseases Institute, Makerere UniversityDepartment of Obstetrics and Gynecology, St Francis Hospital NsambyaCollege of Health Sciences, Makerere UniversityResearch Department, Infectious Diseases Institute, Makerere UniversityDepartment of Pediatrics, St Francis Hospital NsambyaDepartment of Pediatrics, College of Health Sciences, Makerere UniversityDepartment of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical MedicineAbstract Background Many aspects of microbial dissemination appear to vary with host cholesterol levels. Since neonatal septicemia remains a leading cause of newborn admissions and mortality in resource-limited settings, the contribution of abnormal cholesterol levels in maternal and/or newborn blood to the risk of neonatal septicemia and outcome requires elucidation. We aim to determine a relationship between maternal serum and neonatal cord blood cholesterol levels and neonatal septicemia. Methods This will be a mother-newborn pair cohort study. Approximately 353 pregnant women who are eligible and consent to participate in the study will have blood drawn for a lipid profile. Upon delivery, we will analyse the cord blood cholesterol of their newborns and follow them for 28 days to determine whether the infants develop clinical signs and symptoms suggestive of neonatal septicemia. Relative risk will be used to determine the association between cholesterol and newborn septicemia. Poisson regression will be used to estimate the relative risk (with 95% confidence intervals) of developing septicemia. Discussion Findings from our study will contribute evidence to support the inclusion of lipid profile screening for pregnant women and newborns. Our study will determine whether newborns with abnormal cholesterol or those born to mothers with abnormal cholesterol will require rigorous follow-up in neonatal clinics.https://doi.org/10.1186/s12887-022-03494-wNeonatal SepticemiaCholesterolMaternal CholesterolNewbornCord blood |
| spellingShingle | Kenneth Ssebambulidde Anthony Kayiira Ivan Segawa Sylvia Namanda Victoria Nakibuuka Victor Musiime Theresa H. Ward Relationship between maternal and/or newborn cholesterol levels and neonatal septicemia: protocol for a Ugandan cohort of mother-newborn pairs BMC Pediatrics Neonatal Septicemia Cholesterol Maternal Cholesterol Newborn Cord blood |
| title | Relationship between maternal and/or newborn cholesterol levels and neonatal septicemia: protocol for a Ugandan cohort of mother-newborn pairs |
| title_full | Relationship between maternal and/or newborn cholesterol levels and neonatal septicemia: protocol for a Ugandan cohort of mother-newborn pairs |
| title_fullStr | Relationship between maternal and/or newborn cholesterol levels and neonatal septicemia: protocol for a Ugandan cohort of mother-newborn pairs |
| title_full_unstemmed | Relationship between maternal and/or newborn cholesterol levels and neonatal septicemia: protocol for a Ugandan cohort of mother-newborn pairs |
| title_short | Relationship between maternal and/or newborn cholesterol levels and neonatal septicemia: protocol for a Ugandan cohort of mother-newborn pairs |
| title_sort | relationship between maternal and or newborn cholesterol levels and neonatal septicemia protocol for a ugandan cohort of mother newborn pairs |
| topic | Neonatal Septicemia Cholesterol Maternal Cholesterol Newborn Cord blood |
| url | https://doi.org/10.1186/s12887-022-03494-w |
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