Histomorphological Changes in Placentae of Pre-Eclamptic Mothers with Reference to Number of Villi Manifesting Fibrinoid Necrosis
Background: To study the histomorphological changes in placentae of pre-eclamptic mothers and to compare them with placentae of normotensive mothers with reference to number of villi manifesting fibrinoid necrosis Methods: In this comparative study, one hundred placentae were divided into two groups...
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| Format: | Article |
| Language: | English |
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Rawalpindi Medical University
2015-03-01
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| Series: | Journal of Rawalpindi Medical College |
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| Online Access: | https://www.journalrmc.com/index.php/JRMC/article/view/305 |
| Summary: | Background: To study the histomorphological changes in placentae of pre-eclamptic mothers and to compare them with placentae of normotensive mothers with reference to number of villi manifesting fibrinoid necrosis
Methods: In this comparative study, one hundred placentae were divided into two groups. Normotensive (N) Group included fifty placentae of mothers having blood pressure 120/80 to130/80 throughout pregnancy with gestational age between 34-38 weeks. Hypertensive (H) Group included fifty placentae of mothers with blood pressure 140/90 mm of Hg to 160/100 of Hg at two different occasions two hours apart with gestational age 34-38 weeks. Mothers having history of pre-gestational hypertension and diabetes were excluded. After delivery placentae were carefully examined and collected for gross and morphometric study. On microscopic examination terminal villi were recognized as fringing villi containing capillaries and stroma, completely surrounded by blood. Number of villi manifesting fibrinoid necrosis was counted in complete circular cross sections of terminal villi visible in the field . Three fields were randomly selected in each slide from A and B regions .
Results: The number of villi manifesting fibrinoid necrosis was increased in hypertensive group. The quantitative difference between number of villi manifesting fibrinoid necrosis in normal and hypertensive groups was statistically significant.
Conclusion: Increased number of villi manifesting fibrinoid necrosis was observed in (H) group as compared to (N) group that may be the cause or effect of placental hypoxia. |
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| ISSN: | 1683-3562 1683-3570 |