Mechanotransductive receptor Piezo1 as a promising target in the treatment of fibrosis diseases
Fibrosis could happen in every organ, leading to organic malfunction and even organ failure, which poses a serious threat to global health. Early treatment of fibrosis has been reported to be the turning point, therefore, exploring potential correlates in the pathogenesis of fibrosis and how to reve...
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| Format: | Article |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1270979/full |
| _version_ | 1827251013810126848 |
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| author | Yi Xu Yiqian Huang Xiaoqing Cheng Bin Hu Danling Jiang Lidong Wu Shengliang Peng Jialing Hu |
| author_facet | Yi Xu Yiqian Huang Xiaoqing Cheng Bin Hu Danling Jiang Lidong Wu Shengliang Peng Jialing Hu |
| author_sort | Yi Xu |
| collection | DOAJ |
| description | Fibrosis could happen in every organ, leading to organic malfunction and even organ failure, which poses a serious threat to global health. Early treatment of fibrosis has been reported to be the turning point, therefore, exploring potential correlates in the pathogenesis of fibrosis and how to reverse fibrosis has become a pressing issue. As a mechanism-sensitive cationic calcium channel, Piezo1 turns on in response to changes in the lipid bilayer of the plasma membrane. Piezo1 exerts multiple biological roles, including inhibition of inflammation, cytoskeletal stabilization, epithelial-mesenchymal transition, stromal stiffness, and immune cell mechanotransduction, interestingly enough. These processes are closely associated with the development of fibrotic diseases. Recent studies have shown that deletion or knockdown of Piezo1 attenuates the onset of fibrosis. Therefore, in this paper we comprehensively describe the biology of this gene, focusing on its potential relevance in pulmonary fibrosis, renal fibrosis, pancreatic fibrosis, and cardiac fibrosis diseases, except for the role of drugs (agonists), increased intracellular calcium and mechanical stress using this gene in alleviating fibrosis. |
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| format | Article |
| id | doaj.art-eff9af9e1bc4443f98f48fd5e1370090 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2025-03-22T00:12:41Z |
| publishDate | 2023-10-01 |
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| spelling | doaj.art-eff9af9e1bc4443f98f48fd5e13700902024-05-16T06:53:38ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2023-10-011010.3389/fmolb.2023.12709791270979Mechanotransductive receptor Piezo1 as a promising target in the treatment of fibrosis diseasesYi Xu0Yiqian Huang1Xiaoqing Cheng2Bin Hu3Danling Jiang4Lidong Wu5Shengliang Peng6Jialing Hu7The Second Affiliated Hospital of Nanchang University, The Second Clinical Medical College of Nanchang University, Nanchang, ChinaThe Second Affiliated Hospital of Nanchang University, The Second Clinical Medical College of Nanchang University, Nanchang, ChinaDepartment of Emergency Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Emergency Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Ultrasound Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Emergency Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Emergency Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaFibrosis could happen in every organ, leading to organic malfunction and even organ failure, which poses a serious threat to global health. Early treatment of fibrosis has been reported to be the turning point, therefore, exploring potential correlates in the pathogenesis of fibrosis and how to reverse fibrosis has become a pressing issue. As a mechanism-sensitive cationic calcium channel, Piezo1 turns on in response to changes in the lipid bilayer of the plasma membrane. Piezo1 exerts multiple biological roles, including inhibition of inflammation, cytoskeletal stabilization, epithelial-mesenchymal transition, stromal stiffness, and immune cell mechanotransduction, interestingly enough. These processes are closely associated with the development of fibrotic diseases. Recent studies have shown that deletion or knockdown of Piezo1 attenuates the onset of fibrosis. Therefore, in this paper we comprehensively describe the biology of this gene, focusing on its potential relevance in pulmonary fibrosis, renal fibrosis, pancreatic fibrosis, and cardiac fibrosis diseases, except for the role of drugs (agonists), increased intracellular calcium and mechanical stress using this gene in alleviating fibrosis.https://www.frontiersin.org/articles/10.3389/fmolb.2023.1270979/fullPiezo1Piezo2therapeutic targetfibrosisCa2+ |
| spellingShingle | Yi Xu Yiqian Huang Xiaoqing Cheng Bin Hu Danling Jiang Lidong Wu Shengliang Peng Jialing Hu Mechanotransductive receptor Piezo1 as a promising target in the treatment of fibrosis diseases Frontiers in Molecular Biosciences Piezo1 Piezo2 therapeutic target fibrosis Ca2+ |
| title | Mechanotransductive receptor Piezo1 as a promising target in the treatment of fibrosis diseases |
| title_full | Mechanotransductive receptor Piezo1 as a promising target in the treatment of fibrosis diseases |
| title_fullStr | Mechanotransductive receptor Piezo1 as a promising target in the treatment of fibrosis diseases |
| title_full_unstemmed | Mechanotransductive receptor Piezo1 as a promising target in the treatment of fibrosis diseases |
| title_short | Mechanotransductive receptor Piezo1 as a promising target in the treatment of fibrosis diseases |
| title_sort | mechanotransductive receptor piezo1 as a promising target in the treatment of fibrosis diseases |
| topic | Piezo1 Piezo2 therapeutic target fibrosis Ca2+ |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1270979/full |
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