Molecular classification of breast cancer: An overview with emphasis on ethnic variations and future perspectives
Morphologically identical breast cancers can display divergent clinical outcomes and responses to therapy. This can predominantly be attributed to molecular class differences that exist amongst histologically similar cancer types. Consequently, molecular classification can be more powerful than hist...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | Saudi Journal of Medicine and Medical Sciences |
| Subjects: | |
| Online Access: | http://www.sjmms.net/article.asp?issn=1658-631X;year=2013;volume=1;issue=1;spage=14;epage=19;aulast=Shawarby |
| _version_ | 1811296349964992512 |
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| author | Mohamed A Shawarby Dalal M Al-Tamimi Ayesha Ahmed |
| author_facet | Mohamed A Shawarby Dalal M Al-Tamimi Ayesha Ahmed |
| author_sort | Mohamed A Shawarby |
| collection | DOAJ |
| description | Morphologically identical breast cancers can display divergent clinical outcomes and responses to therapy. This can predominantly be attributed to molecular class differences that exist amongst histologically similar cancer types. Consequently, molecular classification can be more powerful than histopathology as a predictive factor for the different treatments. This article reviews the molecular classification of breast cancer and emphasizes that ethnic variations may exist in molecular class prevalence patterns. It also highlights key insights into the currently defined molecular classes as provided by ongoing research on primary breast cancers using recent state-of-the-art technology. Such research is revealing that significant molecular heterogeneity may exist within the molecular classes themselves. More diverse ethnic variations may also be unraveled. The results of ongoing and upcoming research may provide more precise prognostic and predictive information about breast cancer and perhaps a breakthrough step toward "personaliziation" of breast cancer treatment. Forty-one relevant articles (2000-2012) extracted through PubMed and Google advanced searches and at our institute′s library were utilized to prepare the article, along with results of published and ongoing research by the authors. |
| first_indexed | 2024-04-13T05:47:11Z |
| format | Article |
| id | doaj.art-effa43f379c340c88b1f2e4e9e019dfd |
| institution | Directory Open Access Journal |
| issn | 1658-631X |
| language | English |
| last_indexed | 2024-04-13T05:47:11Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal of Medicine and Medical Sciences |
| spelling | doaj.art-effa43f379c340c88b1f2e4e9e019dfd2022-12-22T02:59:55ZengWolters Kluwer Medknow PublicationsSaudi Journal of Medicine and Medical Sciences1658-631X2013-01-0111141910.4103/1658-631X.112908Molecular classification of breast cancer: An overview with emphasis on ethnic variations and future perspectivesMohamed A ShawarbyDalal M Al-TamimiAyesha AhmedMorphologically identical breast cancers can display divergent clinical outcomes and responses to therapy. This can predominantly be attributed to molecular class differences that exist amongst histologically similar cancer types. Consequently, molecular classification can be more powerful than histopathology as a predictive factor for the different treatments. This article reviews the molecular classification of breast cancer and emphasizes that ethnic variations may exist in molecular class prevalence patterns. It also highlights key insights into the currently defined molecular classes as provided by ongoing research on primary breast cancers using recent state-of-the-art technology. Such research is revealing that significant molecular heterogeneity may exist within the molecular classes themselves. More diverse ethnic variations may also be unraveled. The results of ongoing and upcoming research may provide more precise prognostic and predictive information about breast cancer and perhaps a breakthrough step toward "personaliziation" of breast cancer treatment. Forty-one relevant articles (2000-2012) extracted through PubMed and Google advanced searches and at our institute′s library were utilized to prepare the article, along with results of published and ongoing research by the authors.http://www.sjmms.net/article.asp?issn=1658-631X;year=2013;volume=1;issue=1;spage=14;epage=19;aulast=ShawarbyBreast cancerclassificationsmolecularprognosistreatment |
| spellingShingle | Mohamed A Shawarby Dalal M Al-Tamimi Ayesha Ahmed Molecular classification of breast cancer: An overview with emphasis on ethnic variations and future perspectives Saudi Journal of Medicine and Medical Sciences Breast cancer classifications molecular prognosis treatment |
| title | Molecular classification of breast cancer: An overview with emphasis on ethnic variations and future perspectives |
| title_full | Molecular classification of breast cancer: An overview with emphasis on ethnic variations and future perspectives |
| title_fullStr | Molecular classification of breast cancer: An overview with emphasis on ethnic variations and future perspectives |
| title_full_unstemmed | Molecular classification of breast cancer: An overview with emphasis on ethnic variations and future perspectives |
| title_short | Molecular classification of breast cancer: An overview with emphasis on ethnic variations and future perspectives |
| title_sort | molecular classification of breast cancer an overview with emphasis on ethnic variations and future perspectives |
| topic | Breast cancer classifications molecular prognosis treatment |
| url | http://www.sjmms.net/article.asp?issn=1658-631X;year=2013;volume=1;issue=1;spage=14;epage=19;aulast=Shawarby |
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