Factors associated with long-term progression of pediatric chronic kidney disease of nonglomerular etiologies
Background/Purpose: The aims of this study were to determine the long-term associated factors for chronic kidney disease (CKD) progression in a pediatric group with non-glomerular (non-GN) etiologies. Methods: Pediatric patients with a presumptive diagnosis of CKD were enrolled to this study. Record...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-10-01
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| Series: | Journal of the Formosan Medical Association |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664618302821 |
| _version_ | 1818217330072616960 |
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| author | Chih-Chia Chen Hsin-Hsu Chou Yuan-Yow Chiou |
| author_facet | Chih-Chia Chen Hsin-Hsu Chou Yuan-Yow Chiou |
| author_sort | Chih-Chia Chen |
| collection | DOAJ |
| description | Background/Purpose: The aims of this study were to determine the long-term associated factors for chronic kidney disease (CKD) progression in a pediatric group with non-glomerular (non-GN) etiologies. Methods: Pediatric patients with a presumptive diagnosis of CKD were enrolled to this study. Recorded information included demographic and laboratory information. We included the patients with non-GN etiologies and investigated the factors including systolic and diastolic blood pressure (BP), proteinuria, and anemia status in association with reductions in the estimated glomerular filtration rate (eGFR). Results: A total of 308 children were enrolled and the mean duration of follow-up was 4.40 ± 3.53 years. Median baseline age was 5 years old and the males represented 55% of all patients. One-unit increased baseline systolic BP z-score was associated with 1.2 ml/min per 1.73 m2 (95% CI = −2 to −0.5) faster rate of eGFR decline. The presence of baseline proteinuria and anemia were also associated with 4.1 ml/min per 1.73 m2 (95% CI = −5.7 to −2.5) and 2.2 ml/min per 1.73 m2 (95% CI = −3.6 to −0.8) more rapid eGFR declination, respectively. Hypertension, anemia and proteinuria during the follow-up were also associated with 3.25 ml/min per 1.73 m2 (95% CI = −5.32 to −1.18), 4.34 ml/min per 1.73 m2 (95% CI = −7.25 to −1.43) and 4.97 ml/min per 1.73 m2 (95% CI = −8.23 to −1.71) more rapid eGFR declination, respectively. Conclusion: Elevated systolic BP, proteinuria, and anemia are independently associated with CKD progression in pediatric patients with non-GN etiologies. Keywords: Chronic kidney disease, Progression, Children, Congenital anomalies of the kidney and the urinary tract |
| first_indexed | 2024-12-12T07:06:09Z |
| format | Article |
| id | doaj.art-effaa1a4dc49411d874d752e3f8d1a80 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-12T07:06:09Z |
| publishDate | 2019-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-effaa1a4dc49411d874d752e3f8d1a802022-12-22T00:33:44ZengElsevierJournal of the Formosan Medical Association0929-66462019-10-011181014231429Factors associated with long-term progression of pediatric chronic kidney disease of nonglomerular etiologiesChih-Chia Chen0Hsin-Hsu Chou1Yuan-Yow Chiou2Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Pediatrics, Ditmanson Medical Foundation Chiayi Christian Hospital, Chia-Yi, TaiwanDepartment of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Clinical Medicine, National Cheng-Kung University Hospital, College of Medicine, Tainan, Taiwan; Corresponding author. Department of Pediatrics, Institute of Clinical Medicine, National Cheng-Kung University Hospital, College of Medicine, 138 Sheng-Li Rd., Tainan, Taiwan.Background/Purpose: The aims of this study were to determine the long-term associated factors for chronic kidney disease (CKD) progression in a pediatric group with non-glomerular (non-GN) etiologies. Methods: Pediatric patients with a presumptive diagnosis of CKD were enrolled to this study. Recorded information included demographic and laboratory information. We included the patients with non-GN etiologies and investigated the factors including systolic and diastolic blood pressure (BP), proteinuria, and anemia status in association with reductions in the estimated glomerular filtration rate (eGFR). Results: A total of 308 children were enrolled and the mean duration of follow-up was 4.40 ± 3.53 years. Median baseline age was 5 years old and the males represented 55% of all patients. One-unit increased baseline systolic BP z-score was associated with 1.2 ml/min per 1.73 m2 (95% CI = −2 to −0.5) faster rate of eGFR decline. The presence of baseline proteinuria and anemia were also associated with 4.1 ml/min per 1.73 m2 (95% CI = −5.7 to −2.5) and 2.2 ml/min per 1.73 m2 (95% CI = −3.6 to −0.8) more rapid eGFR declination, respectively. Hypertension, anemia and proteinuria during the follow-up were also associated with 3.25 ml/min per 1.73 m2 (95% CI = −5.32 to −1.18), 4.34 ml/min per 1.73 m2 (95% CI = −7.25 to −1.43) and 4.97 ml/min per 1.73 m2 (95% CI = −8.23 to −1.71) more rapid eGFR declination, respectively. Conclusion: Elevated systolic BP, proteinuria, and anemia are independently associated with CKD progression in pediatric patients with non-GN etiologies. Keywords: Chronic kidney disease, Progression, Children, Congenital anomalies of the kidney and the urinary tracthttp://www.sciencedirect.com/science/article/pii/S0929664618302821 |
| spellingShingle | Chih-Chia Chen Hsin-Hsu Chou Yuan-Yow Chiou Factors associated with long-term progression of pediatric chronic kidney disease of nonglomerular etiologies Journal of the Formosan Medical Association |
| title | Factors associated with long-term progression of pediatric chronic kidney disease of nonglomerular etiologies |
| title_full | Factors associated with long-term progression of pediatric chronic kidney disease of nonglomerular etiologies |
| title_fullStr | Factors associated with long-term progression of pediatric chronic kidney disease of nonglomerular etiologies |
| title_full_unstemmed | Factors associated with long-term progression of pediatric chronic kidney disease of nonglomerular etiologies |
| title_short | Factors associated with long-term progression of pediatric chronic kidney disease of nonglomerular etiologies |
| title_sort | factors associated with long term progression of pediatric chronic kidney disease of nonglomerular etiologies |
| url | http://www.sciencedirect.com/science/article/pii/S0929664618302821 |
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