Anti-Inflammatory Actions of G-Protein-Coupled Estrogen Receptor 1 (GPER) and Brain-Derived Estrogen Following Cerebral Ischemia in Ovariectomized Rats

Anti-Inflammatory Actions of G-Protein-Coupled Estrogen Receptor 1 (GPER) and Brain-Derived Estrogen Following Cerebral Ischemia in Ovariectomized Rats

Global cerebral ischemia can elicit rapid innate neuroprotective mechanisms that protect against delayed neuronal death. Brain-derived 17β-estradiol (BDE2), an endogenous neuroprotectant, is synthesized from testosterone by the enzyme aromatase (Aro) and is upregulated by brain ischemia and inflamma...

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Bibliographic Details
Main Authors: Jing Xu, Jing Bai, Fujia Gao, Chao Xu, Yuanyuan Huang, Danyang Li, Lu Wang, Ruimin Wang
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Biology
Subjects:
global cerebral ischemia
G-protein-coupled estrogen receptor 1
aromatase
brain-derived estrogen
inflammation
Online Access:https://www.mdpi.com/2079-7737/12/1/99

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