Real-Time Two-Dimensional Magnetic Particle Imaging for Electromagnetic Navigation in Targeted Drug Delivery
Magnetic nanoparticles (MNPs) are effective drug carriers. By using electromagnetic actuated systems, MNPs can be controlled noninvasively in a vascular network for targeted drug delivery (TDD). Although drugs can reach their target location through capturing schemes of MNPs by permanent magnets, dr...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-09-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/17/9/2050 |
| _version_ | 1818035564539019264 |
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| author | Tuan-Anh Le Xingming Zhang Ali Kafash Hoshiar Jungwon Yoon |
| author_facet | Tuan-Anh Le Xingming Zhang Ali Kafash Hoshiar Jungwon Yoon |
| author_sort | Tuan-Anh Le |
| collection | DOAJ |
| description | Magnetic nanoparticles (MNPs) are effective drug carriers. By using electromagnetic actuated systems, MNPs can be controlled noninvasively in a vascular network for targeted drug delivery (TDD). Although drugs can reach their target location through capturing schemes of MNPs by permanent magnets, drugs delivered to non-target regions can affect healthy tissues and cause undesirable side effects. Real-time monitoring of MNPs can improve the targeting efficiency of TDD systems. In this paper, a two-dimensional (2D) real-time monitoring scheme has been developed for an MNP guidance system. Resovist particles 45 to 65 nm in diameter (5 nm core) can be monitored in real-time (update rate = 2 Hz) in 2D. The proposed 2D monitoring system allows dynamic tracking of MNPs during TDD and renders magnetic particle imaging-based navigation more feasible. |
| first_indexed | 2024-12-10T06:57:04Z |
| format | Article |
| id | doaj.art-effc88c7577b4fab9432bd98eea12d4c |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-12-10T06:57:04Z |
| publishDate | 2017-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-effc88c7577b4fab9432bd98eea12d4c2022-12-22T01:58:25ZengMDPI AGSensors1424-82202017-09-01179205010.3390/s17092050s17092050Real-Time Two-Dimensional Magnetic Particle Imaging for Electromagnetic Navigation in Targeted Drug DeliveryTuan-Anh Le0Xingming Zhang1Ali Kafash Hoshiar2Jungwon Yoon3School of Mechanical and Aerospace Engineering & ReCAPT, Gyeongsang National University, Jinju 660-701, KoreaSchool of Naval Architecture and Ocean Engineering, Harbin Institute of Technology at Weihai, Weihai 264209, ChinaFaculty of Industrial and Mechanical Engineering, Islamic Azad University, Qazvin Branch, Qazvin 34199-15195, IranSchool of Mechanical and Aerospace Engineering & ReCAPT, Gyeongsang National University, Jinju 660-701, KoreaMagnetic nanoparticles (MNPs) are effective drug carriers. By using electromagnetic actuated systems, MNPs can be controlled noninvasively in a vascular network for targeted drug delivery (TDD). Although drugs can reach their target location through capturing schemes of MNPs by permanent magnets, drugs delivered to non-target regions can affect healthy tissues and cause undesirable side effects. Real-time monitoring of MNPs can improve the targeting efficiency of TDD systems. In this paper, a two-dimensional (2D) real-time monitoring scheme has been developed for an MNP guidance system. Resovist particles 45 to 65 nm in diameter (5 nm core) can be monitored in real-time (update rate = 2 Hz) in 2D. The proposed 2D monitoring system allows dynamic tracking of MNPs during TDD and renders magnetic particle imaging-based navigation more feasible.https://www.mdpi.com/1424-8220/17/9/2050magnetic particle imagingnavigation resolutionmagnetic nanoparticles |
| spellingShingle | Tuan-Anh Le Xingming Zhang Ali Kafash Hoshiar Jungwon Yoon Real-Time Two-Dimensional Magnetic Particle Imaging for Electromagnetic Navigation in Targeted Drug Delivery Sensors magnetic particle imaging navigation resolution magnetic nanoparticles |
| title | Real-Time Two-Dimensional Magnetic Particle Imaging for Electromagnetic Navigation in Targeted Drug Delivery |
| title_full | Real-Time Two-Dimensional Magnetic Particle Imaging for Electromagnetic Navigation in Targeted Drug Delivery |
| title_fullStr | Real-Time Two-Dimensional Magnetic Particle Imaging for Electromagnetic Navigation in Targeted Drug Delivery |
| title_full_unstemmed | Real-Time Two-Dimensional Magnetic Particle Imaging for Electromagnetic Navigation in Targeted Drug Delivery |
| title_short | Real-Time Two-Dimensional Magnetic Particle Imaging for Electromagnetic Navigation in Targeted Drug Delivery |
| title_sort | real time two dimensional magnetic particle imaging for electromagnetic navigation in targeted drug delivery |
| topic | magnetic particle imaging navigation resolution magnetic nanoparticles |
| url | https://www.mdpi.com/1424-8220/17/9/2050 |
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