Choice impulsivity after repeated social stress is associated with increased perineuronal nets in the medial prefrontal cortex
Abstract Repeated stress can predispose to substance abuse. However, behavioral and neurobiological adaptations that link stress to substance abuse remain unclear. This study investigates whether intermittent social defeat (ISD), a stress protocol that promotes drug-seeking behavior, alters intertem...
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Nature Portfolio
2024-03-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-57599-6 |
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| author | Christopher A. Martinez Harry Pantazopoulos Barbara Gisabella Emily T. Stephens Jacob Garteiser Alberto Del Arco |
| author_facet | Christopher A. Martinez Harry Pantazopoulos Barbara Gisabella Emily T. Stephens Jacob Garteiser Alberto Del Arco |
| author_sort | Christopher A. Martinez |
| collection | DOAJ |
| description | Abstract Repeated stress can predispose to substance abuse. However, behavioral and neurobiological adaptations that link stress to substance abuse remain unclear. This study investigates whether intermittent social defeat (ISD), a stress protocol that promotes drug-seeking behavior, alters intertemporal decision-making and cortical inhibitory function in the medial prefrontal cortex (mPFC). Male long evans rats were trained in a delay discounting task (DDT) where rats make a choice between a fast (1 s) small reward (1 sugar pellet) and a large reward (3 sugar pellets) that comes with a time delay (10 s or 20 s). A decreased preference for delayed rewards was used as an index of choice impulsivity. Rats were exposed to ISD and tested in the DDT 24 h after each stress episode, and one- and two-weeks after the last stress episode. Immunohistochemistry was performed in rat’s brains to evaluate perineuronal nets (PNNs) and parvalbumin GABA interneurons (PV) labeling as markers of inhibitory function in mPFC. ISD significantly decreased the preference for delayed large rewards in low impulsive, but not high impulsive, animals. ISD also increased the density of PNNs in the mPFC. These results suggest that increased choice impulsivity and cortical inhibition predispose animals to seek out rewards after stress. |
| first_indexed | 2024-04-24T16:19:14Z |
| format | Article |
| id | doaj.art-effde1a9be9a4b778918fd4c9e7c668a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T16:19:14Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
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| spelling | doaj.art-effde1a9be9a4b778918fd4c9e7c668a2024-03-31T11:18:12ZengNature PortfolioScientific Reports2045-23222024-03-0114111310.1038/s41598-024-57599-6Choice impulsivity after repeated social stress is associated with increased perineuronal nets in the medial prefrontal cortexChristopher A. Martinez0Harry Pantazopoulos1Barbara Gisabella2Emily T. Stephens3Jacob Garteiser4Alberto Del Arco5HESRM, School of Applied Sciences, University of MississippiDepartment of Psychiatry and Human Behavior, Medical School, University of Mississippi Medical CenterDepartment of Psychiatry and Human Behavior, Medical School, University of Mississippi Medical CenterDepartment of Psychiatry and Human Behavior, Medical School, University of Mississippi Medical CenterDepartment of Psychiatry and Human Behavior, Medical School, University of Mississippi Medical CenterHESRM, School of Applied Sciences, University of MississippiAbstract Repeated stress can predispose to substance abuse. However, behavioral and neurobiological adaptations that link stress to substance abuse remain unclear. This study investigates whether intermittent social defeat (ISD), a stress protocol that promotes drug-seeking behavior, alters intertemporal decision-making and cortical inhibitory function in the medial prefrontal cortex (mPFC). Male long evans rats were trained in a delay discounting task (DDT) where rats make a choice between a fast (1 s) small reward (1 sugar pellet) and a large reward (3 sugar pellets) that comes with a time delay (10 s or 20 s). A decreased preference for delayed rewards was used as an index of choice impulsivity. Rats were exposed to ISD and tested in the DDT 24 h after each stress episode, and one- and two-weeks after the last stress episode. Immunohistochemistry was performed in rat’s brains to evaluate perineuronal nets (PNNs) and parvalbumin GABA interneurons (PV) labeling as markers of inhibitory function in mPFC. ISD significantly decreased the preference for delayed large rewards in low impulsive, but not high impulsive, animals. ISD also increased the density of PNNs in the mPFC. These results suggest that increased choice impulsivity and cortical inhibition predispose animals to seek out rewards after stress.https://doi.org/10.1038/s41598-024-57599-6Social stressDecision-makingReward-seekingImpulsivityInterneuronsExtracellular matrix |
| spellingShingle | Christopher A. Martinez Harry Pantazopoulos Barbara Gisabella Emily T. Stephens Jacob Garteiser Alberto Del Arco Choice impulsivity after repeated social stress is associated with increased perineuronal nets in the medial prefrontal cortex Scientific Reports Social stress Decision-making Reward-seeking Impulsivity Interneurons Extracellular matrix |
| title | Choice impulsivity after repeated social stress is associated with increased perineuronal nets in the medial prefrontal cortex |
| title_full | Choice impulsivity after repeated social stress is associated with increased perineuronal nets in the medial prefrontal cortex |
| title_fullStr | Choice impulsivity after repeated social stress is associated with increased perineuronal nets in the medial prefrontal cortex |
| title_full_unstemmed | Choice impulsivity after repeated social stress is associated with increased perineuronal nets in the medial prefrontal cortex |
| title_short | Choice impulsivity after repeated social stress is associated with increased perineuronal nets in the medial prefrontal cortex |
| title_sort | choice impulsivity after repeated social stress is associated with increased perineuronal nets in the medial prefrontal cortex |
| topic | Social stress Decision-making Reward-seeking Impulsivity Interneurons Extracellular matrix |
| url | https://doi.org/10.1038/s41598-024-57599-6 |
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