Association between serum level of vitamin D (25-hydroxyvitamin D) and plasma level of vitamin D receptor with bacteriological index in leprosy patients
Macrophages respond against Mycobacterium leprae infection through interacting with vitamin D and vitamin D receptor (VDR). There has been no study analyzing the association between vitamin D and VDR with bacteriological index (BI) in leprosy patients in Indonesia. To analyze the serum level of 25-...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2023-05-01
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| Series: | Dermatology Reports |
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| Online Access: | https://www.pagepress.org/journals/index.php/dr/article/view/9705 |
| _version_ | 1797821253830049792 |
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| author | Rizka Farah Hilma Sandra Widaty Melani Marissa Muhammad Ilyas |
| author_facet | Rizka Farah Hilma Sandra Widaty Melani Marissa Muhammad Ilyas |
| author_sort | Rizka Farah Hilma |
| collection | DOAJ |
| description |
Macrophages respond against Mycobacterium leprae infection through interacting with vitamin D and vitamin D receptor (VDR). There has been no study analyzing the association between vitamin D and VDR with bacteriological index (BI) in leprosy patients in Indonesia. To analyze the serum level of 25-hydroxyvitamin D₃ (25(OH)D) and plasma level of VDR as well as their association with BI in leprosy patients in Indonesia. This is a cross-sectional study. Serum level of 25(OH)D was assessed with in vitro chemiluminescent immunoassay (CLIA). Plasma level of VDR was assessed with enzyme linked immunosorbent assay (ELISA) method. Median serum level of 25(OH)D was 12.68 ng/ml. There was no correlation between serum level of 25(OH)D and BI (r=0.033; p=0.869). Median plasma level of VDR was 1.36 ng/ml. There was no correlation between plasma level of VDR and BI (r=-0.063; p=0.749) and no significant association between BI and serum level of 25(OH) and plasma level of VDR (R2=0.055). There was no association between serum level of 25(OH)D and plasma level of VDR with BI in leprosy patients.
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| first_indexed | 2024-03-13T09:50:01Z |
| format | Article |
| id | doaj.art-f000962ad86a4735ac34ae43d6165350 |
| institution | Directory Open Access Journal |
| issn | 2036-7392 2036-7406 |
| language | English |
| last_indexed | 2024-03-13T09:50:01Z |
| publishDate | 2023-05-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Dermatology Reports |
| spelling | doaj.art-f000962ad86a4735ac34ae43d61653502023-05-24T17:59:02ZengPAGEPress PublicationsDermatology Reports2036-73922036-74062023-05-0110.4081/dr.2023.9705Association between serum level of vitamin D (25-hydroxyvitamin D) and plasma level of vitamin D receptor with bacteriological index in leprosy patientsRizka Farah Hilma0Sandra Widaty1Melani Marissa2Muhammad Ilyas3Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, JakartaDepartment of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, JakartaDepartment of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, JakartaDepartment of Community Medical Science, Faculty of Medicine Universitas Indonesia, Jakarta Macrophages respond against Mycobacterium leprae infection through interacting with vitamin D and vitamin D receptor (VDR). There has been no study analyzing the association between vitamin D and VDR with bacteriological index (BI) in leprosy patients in Indonesia. To analyze the serum level of 25-hydroxyvitamin D₃ (25(OH)D) and plasma level of VDR as well as their association with BI in leprosy patients in Indonesia. This is a cross-sectional study. Serum level of 25(OH)D was assessed with in vitro chemiluminescent immunoassay (CLIA). Plasma level of VDR was assessed with enzyme linked immunosorbent assay (ELISA) method. Median serum level of 25(OH)D was 12.68 ng/ml. There was no correlation between serum level of 25(OH)D and BI (r=0.033; p=0.869). Median plasma level of VDR was 1.36 ng/ml. There was no correlation between plasma level of VDR and BI (r=-0.063; p=0.749) and no significant association between BI and serum level of 25(OH) and plasma level of VDR (R2=0.055). There was no association between serum level of 25(OH)D and plasma level of VDR with BI in leprosy patients. https://www.pagepress.org/journals/index.php/dr/article/view/9705vitamin Dvitamin D receptorbacteriological indexleprosysun exposure |
| spellingShingle | Rizka Farah Hilma Sandra Widaty Melani Marissa Muhammad Ilyas Association between serum level of vitamin D (25-hydroxyvitamin D) and plasma level of vitamin D receptor with bacteriological index in leprosy patients Dermatology Reports vitamin D vitamin D receptor bacteriological index leprosy sun exposure |
| title | Association between serum level of vitamin D (25-hydroxyvitamin D) and plasma level of vitamin D receptor with bacteriological index in leprosy patients |
| title_full | Association between serum level of vitamin D (25-hydroxyvitamin D) and plasma level of vitamin D receptor with bacteriological index in leprosy patients |
| title_fullStr | Association between serum level of vitamin D (25-hydroxyvitamin D) and plasma level of vitamin D receptor with bacteriological index in leprosy patients |
| title_full_unstemmed | Association between serum level of vitamin D (25-hydroxyvitamin D) and plasma level of vitamin D receptor with bacteriological index in leprosy patients |
| title_short | Association between serum level of vitamin D (25-hydroxyvitamin D) and plasma level of vitamin D receptor with bacteriological index in leprosy patients |
| title_sort | association between serum level of vitamin d 25 hydroxyvitamin d and plasma level of vitamin d receptor with bacteriological index in leprosy patients |
| topic | vitamin D vitamin D receptor bacteriological index leprosy sun exposure |
| url | https://www.pagepress.org/journals/index.php/dr/article/view/9705 |
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