Thyroid Hormones and Cancer: A Comprehensive Review of Preclinical and Clinical Studies
Thyroid hormones take major part in normal growth, development and metabolism. Over a century of research has supported a relationship between thyroid hormones and the pathophysiology of various cancer types. In vitro studies as well as research in animal models demonstrated an effect of the thyroid...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2019.00059/full |
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| author | Eilon Krashin Eilon Krashin Agnieszka Piekiełko-Witkowska Martin Ellis Martin Ellis Martin Ellis Osnat Ashur-Fabian Osnat Ashur-Fabian |
| author_facet | Eilon Krashin Eilon Krashin Agnieszka Piekiełko-Witkowska Martin Ellis Martin Ellis Martin Ellis Osnat Ashur-Fabian Osnat Ashur-Fabian |
| author_sort | Eilon Krashin |
| collection | DOAJ |
| description | Thyroid hormones take major part in normal growth, development and metabolism. Over a century of research has supported a relationship between thyroid hormones and the pathophysiology of various cancer types. In vitro studies as well as research in animal models demonstrated an effect of the thyroid hormones T3 and T4 on cancer proliferation, apoptosis, invasiveness and angiogenesis. Thyroid hormones mediate their effects on the cancer cell through several non-genomic pathways including activation of the plasma membrane receptor integrin αvβ3. Furthermore, cancer development and progression are affected by dysregulation of local bioavailability of thyroid hormones. Case-control and population-based studies provide conflicting results regarding the association between thyroid hormones and cancer. However, a large body of evidence suggests that subclinical and clinical hyperthyroidism increase the risk of several solid malignancies while hypothyroidism may reduce aggressiveness or delay the onset of cancer. Additional support is provided from studies in which dysregulation of the thyroid hormone axis secondary to cancer treatment or thyroid hormone supplementation was shown to affect cancer outcomes. Recent preclinical and clinical studies in various cancer types have further shown promising outcomes following chemical reduction of thyroid hormones or inhibition or their binding to the integrin receptor. This review provides a comprehensive overview of the preclinical and clinical research conducted so far. |
| first_indexed | 2024-04-12T04:41:48Z |
| format | Article |
| id | doaj.art-f00162e7f27c467691a27b70d5dfe4dd |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-12T04:41:48Z |
| publishDate | 2019-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-f00162e7f27c467691a27b70d5dfe4dd2022-12-22T03:47:37ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922019-02-011010.3389/fendo.2019.00059440635Thyroid Hormones and Cancer: A Comprehensive Review of Preclinical and Clinical StudiesEilon Krashin0Eilon Krashin1Agnieszka Piekiełko-Witkowska2Martin Ellis3Martin Ellis4Martin Ellis5Osnat Ashur-Fabian6Osnat Ashur-Fabian7Translational Hemato-Oncology Laboratory, Meir Medical Center, Kfar-Saba, IsraelDepartment of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelDepartment of Biochemistry and Molecular Biology, Centre of Postgraduate Medical Education, Warsaw, PolandTranslational Hemato-Oncology Laboratory, Meir Medical Center, Kfar-Saba, IsraelMeir Medical Center, Hematology Institute and Blood Bank, Kfar-Saba, IsraelSackler School of Medicine, Tel Aviv University, Tel Aviv, IsraelTranslational Hemato-Oncology Laboratory, Meir Medical Center, Kfar-Saba, IsraelDepartment of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelThyroid hormones take major part in normal growth, development and metabolism. Over a century of research has supported a relationship between thyroid hormones and the pathophysiology of various cancer types. In vitro studies as well as research in animal models demonstrated an effect of the thyroid hormones T3 and T4 on cancer proliferation, apoptosis, invasiveness and angiogenesis. Thyroid hormones mediate their effects on the cancer cell through several non-genomic pathways including activation of the plasma membrane receptor integrin αvβ3. Furthermore, cancer development and progression are affected by dysregulation of local bioavailability of thyroid hormones. Case-control and population-based studies provide conflicting results regarding the association between thyroid hormones and cancer. However, a large body of evidence suggests that subclinical and clinical hyperthyroidism increase the risk of several solid malignancies while hypothyroidism may reduce aggressiveness or delay the onset of cancer. Additional support is provided from studies in which dysregulation of the thyroid hormone axis secondary to cancer treatment or thyroid hormone supplementation was shown to affect cancer outcomes. Recent preclinical and clinical studies in various cancer types have further shown promising outcomes following chemical reduction of thyroid hormones or inhibition or their binding to the integrin receptor. This review provides a comprehensive overview of the preclinical and clinical research conducted so far.https://www.frontiersin.org/article/10.3389/fendo.2019.00059/fullcancerthyroid hormonetriiodothyroninethyroxineαvβ3 integrin |
| spellingShingle | Eilon Krashin Eilon Krashin Agnieszka Piekiełko-Witkowska Martin Ellis Martin Ellis Martin Ellis Osnat Ashur-Fabian Osnat Ashur-Fabian Thyroid Hormones and Cancer: A Comprehensive Review of Preclinical and Clinical Studies Frontiers in Endocrinology cancer thyroid hormone triiodothyronine thyroxine αvβ3 integrin |
| title | Thyroid Hormones and Cancer: A Comprehensive Review of Preclinical and Clinical Studies |
| title_full | Thyroid Hormones and Cancer: A Comprehensive Review of Preclinical and Clinical Studies |
| title_fullStr | Thyroid Hormones and Cancer: A Comprehensive Review of Preclinical and Clinical Studies |
| title_full_unstemmed | Thyroid Hormones and Cancer: A Comprehensive Review of Preclinical and Clinical Studies |
| title_short | Thyroid Hormones and Cancer: A Comprehensive Review of Preclinical and Clinical Studies |
| title_sort | thyroid hormones and cancer a comprehensive review of preclinical and clinical studies |
| topic | cancer thyroid hormone triiodothyronine thyroxine αvβ3 integrin |
| url | https://www.frontiersin.org/article/10.3389/fendo.2019.00059/full |
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