Functional Analysis of Human Sodium-Phosphate Transporter 4 (NPT4/SLC17A3) Polymorphisms
We analyzed the functional properties of five nonsynonymous single nucleotide polymorphisms (SNPs) in the sodium-phosphate transporter NPT4 gene (SLC17A3) using the Xenopus oocyte expression system. NPT4 variants carrying SNP V257F, G279R, or P378L exhibited reduced transport of [14C]para-aminohippu...
Main Authors: | Promsuk Jutabha, Naohiko Anzai, Toru Kimura, Atsuo Taniguchi, Wako Urano, Hisashi Yamanaka, Hitoshi Endou, Hiroyuki Sakurai |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2011-01-01
|
Series: | Journal of Pharmacological Sciences |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319307509 |
Similar Items
-
Molecular Mechanism of Ochratoxin A Transport in the Kidney
by: Naohiko Anzai, et al.
Published: (2010-06-01) -
Human Organic Anion Transporter 4 Is a Renal Apical Organic Anion/Dicarboxylate Exchanger in the Proximal Tubules
by: Sophapun Ekaratanawong, et al.
Published: (2004-01-01) -
Hypouricemia and nephroprotection of Coix lacryma-jobi L. seed extract
by: Ormjai Taejarernwiriyakul, et al.
Published: (2015-08-01) -
Is the NPT Still Relevant? – How to Progress the NPT’s Disarmament Provisions
by: John Carlson
Published: (2019-01-01) -
Effects of pharmacological inhibition of the sodium‐dependent phosphate cotransporter 2b (NPT2b) on intestinal phosphate absorption in mouse and rat models
by: Xiaojun Wang, et al.
Published: (2022-04-01)