Masked polycythemia vera manifested by splanchnic venous thrombosis during pregnancy: a clinical case
Ph-negative myeloproliferative disorders such as polycythemia vera (PV), essential thrombocythemia, and primary myelofibrosis are rare clonal hematopoietic diseases that typically occur at age over 50. Only 10–15% of PV cases are diagnosed during the reproductive years, most commonly manifested as s...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2022-05-01
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| Series: | Акушерство, гинекология и репродукция |
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| Online Access: | https://www.gynecology.su/jour/article/view/1313 |
| _version_ | 1797884096382238720 |
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| author | M. Yu. Nadinskaia Kh. B. Kodzoeva M. A. Sokolova S. V. Apresyan E. Yu. Kryzhanovskaya A. A. Shchukina E. A. Kitsenko |
| author_facet | M. Yu. Nadinskaia Kh. B. Kodzoeva M. A. Sokolova S. V. Apresyan E. Yu. Kryzhanovskaya A. A. Shchukina E. A. Kitsenko |
| author_sort | M. Yu. Nadinskaia |
| collection | DOAJ |
| description | Ph-negative myeloproliferative disorders such as polycythemia vera (PV), essential thrombocythemia, and primary myelofibrosis are rare clonal hematopoietic diseases that typically occur at age over 50. Only 10–15% of PV cases are diagnosed during the reproductive years, most commonly manifested as splanchnic venous thrombosis (SVT). Here, we demonstrate a case of a 6-weeks pregnant woman with a history of stillbirth and miscarriage presented with SVT. A terminal ileal resection and right hemicolectomy were performed, as well as the appointment of low molecular weight heparin in the postoperative period was initiated that allowed the patient to continue the pregnancy and deliver a child. The JAK2 V617F mutation was detected and masked PV was diagnosed according to bone marrow findings. In this article, we discuss the etiology of SVT in adults and effect of JAK2 V617F mutation on pregnancy outcomes as well as summarize current knowledge about pregnancy outcomes in PV. |
| first_indexed | 2024-04-10T04:01:05Z |
| format | Article |
| id | doaj.art-f00622d0d0af43a2aeb34ee795751905 |
| institution | Directory Open Access Journal |
| issn | 2313-7347 2500-3194 |
| language | Russian |
| last_indexed | 2024-04-10T04:01:05Z |
| publishDate | 2022-05-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Акушерство, гинекология и репродукция |
| spelling | doaj.art-f00622d0d0af43a2aeb34ee7957519052023-03-13T07:09:52ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942022-05-0116219420310.17749/2313-7347/ob.gyn.rep.2022.288721Masked polycythemia vera manifested by splanchnic venous thrombosis during pregnancy: a clinical caseM. Yu. Nadinskaia0Kh. B. Kodzoeva1M. A. Sokolova2S. V. Apresyan3E. Yu. Kryzhanovskaya4A. A. Shchukina5E. A. Kitsenko6Sechenov UniversitySechenov UniversityNational Research Center for HematologyPirogov National Medical and Surgical Center; Eramishantsev City Clinical HospitalPetrovsky National Research Centre of SurgeryPetrovsky National Research Centre of SurgeryPetrovsky National Research Centre of SurgeryPh-negative myeloproliferative disorders such as polycythemia vera (PV), essential thrombocythemia, and primary myelofibrosis are rare clonal hematopoietic diseases that typically occur at age over 50. Only 10–15% of PV cases are diagnosed during the reproductive years, most commonly manifested as splanchnic venous thrombosis (SVT). Here, we demonstrate a case of a 6-weeks pregnant woman with a history of stillbirth and miscarriage presented with SVT. A terminal ileal resection and right hemicolectomy were performed, as well as the appointment of low molecular weight heparin in the postoperative period was initiated that allowed the patient to continue the pregnancy and deliver a child. The JAK2 V617F mutation was detected and masked PV was diagnosed according to bone marrow findings. In this article, we discuss the etiology of SVT in adults and effect of JAK2 V617F mutation on pregnancy outcomes as well as summarize current knowledge about pregnancy outcomes in PV.https://www.gynecology.su/jour/article/view/1313myeloproliferative disorderspolycythemia verapvjak2 v617f mutationrecurrent pregnancy lossportal vein thrombosisanticoagulation therapy |
| spellingShingle | M. Yu. Nadinskaia Kh. B. Kodzoeva M. A. Sokolova S. V. Apresyan E. Yu. Kryzhanovskaya A. A. Shchukina E. A. Kitsenko Masked polycythemia vera manifested by splanchnic venous thrombosis during pregnancy: a clinical case Акушерство, гинекология и репродукция myeloproliferative disorders polycythemia vera pv jak2 v617f mutation recurrent pregnancy loss portal vein thrombosis anticoagulation therapy |
| title | Masked polycythemia vera manifested by splanchnic venous thrombosis during pregnancy: a clinical case |
| title_full | Masked polycythemia vera manifested by splanchnic venous thrombosis during pregnancy: a clinical case |
| title_fullStr | Masked polycythemia vera manifested by splanchnic venous thrombosis during pregnancy: a clinical case |
| title_full_unstemmed | Masked polycythemia vera manifested by splanchnic venous thrombosis during pregnancy: a clinical case |
| title_short | Masked polycythemia vera manifested by splanchnic venous thrombosis during pregnancy: a clinical case |
| title_sort | masked polycythemia vera manifested by splanchnic venous thrombosis during pregnancy a clinical case |
| topic | myeloproliferative disorders polycythemia vera pv jak2 v617f mutation recurrent pregnancy loss portal vein thrombosis anticoagulation therapy |
| url | https://www.gynecology.su/jour/article/view/1313 |
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