Carbonic anhydrase-8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway.

Carbonic anhydrase-8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway.

Calcium dysregulation is causally linked with various forms of neuropathology including seizure disorders, multiple sclerosis, Huntington's disease, Alzheimer's, spinal cerebellar ataxia (SCA) and chronic pain. Carbonic anhydrase-8 (Car8) is an allosteric inhibitor of inositol trisphosphat...

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Bibliographic Details
Main Authors: Gerald Z Zhuang, Benjamin Keeler, Jeff Grant, Laura Bianchi, Eugene S Fu, Yan Ping Zhang, Diana M Erasso, Jian-Guo Cui, Tim Wiltshire, Qiongzhen Li, Shuanglin Hao, Konstantinos D Sarantopoulos, Keith Candiotti, Sarah M Wishnek, Shad B Smith, William Maixner, Luda Diatchenko, Eden R Martin, Roy C Levitt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4347988?pdf=render

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