Effects of a fixed-dose combination of ACE inhibitor and nondihydropyridine calcium antagonist on endothelial dysfunction in patients with essential arterial hypertension
Aim. To study the effects of the fixed combination trandolapril 2 mg + verapamil 120 mg medication on endothelial function in patents with Stage II-III essential arterial hypertension (AH). Material and methods. In total, 39 AH patients were examined (mean age 66,7±6,9 years; Stage II and III AH – i...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
«SILICEA-POLIGRAF» LLC
2010-04-01
|
| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/2033 |
| _version_ | 1797882634506862592 |
|---|---|
| author | O. D. Ostroumova O. V. Zhukova I. V. Khvorostyanaya V. V. Vikentyev G. I. Barilo T. F. Tremasova |
| author_facet | O. D. Ostroumova O. V. Zhukova I. V. Khvorostyanaya V. V. Vikentyev G. I. Barilo T. F. Tremasova |
| author_sort | O. D. Ostroumova |
| collection | DOAJ |
| description | Aim. To study the effects of the fixed combination trandolapril 2 mg + verapamil 120 mg medication on endothelial function in patents with Stage II-III essential arterial hypertension (AH). Material and methods. In total, 39 AH patients were examined (mean age 66,7±6,9 years; Stage II and III AH – in 41,0% and 59,0%, respectively). At baseline and during the treatment phase, blood pressure (BP) measurement, 24-hour BP monitoring (BPM), and endothelium-dependent vasodilatation (EDVD) assessment were performed. All patients received the fixed combination trandolapril 2 mg + verapamil 120 mg in the dose of 1 tablet once a day, in the morning; if after four weeks, routinely measured BP did not achieve target levels (<140/90 mm Hg), the dose was increased up to 2 tablets once a day. The follow-up period lasted for 24 weeks. Results. A significant reduction (p<0,05) in “office” systolic and diastolic BP (SBP, DBP) levels – by 36,3 and 24,4 mm Hg, respectively – was observed. At baseline, endothelial dysfunction was registered in 15 individuals. After 24 weeks of the therapy, EDVD normalized in 9 out of 15 patients (60,0%), and improved in other 6 (40,0%). Conclusion. The fixed-dose combined medication, the fixed combination trandolapril 2 mg + verapamil 120 mg, administered to patients with Stage II-III AH for 24 weeks, significantly reduced SBP and DBP levels and improved endothelial function. |
| first_indexed | 2024-04-10T03:38:56Z |
| format | Article |
| id | doaj.art-f006bfa612d44ba1954a330b62d7d222 |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:38:56Z |
| publishDate | 2010-04-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-f006bfa612d44ba1954a330b62d7d2222023-03-13T07:23:18Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252010-04-019221261745Effects of a fixed-dose combination of ACE inhibitor and nondihydropyridine calcium antagonist on endothelial dysfunction in patients with essential arterial hypertensionO. D. Ostroumova0O. V. Zhukova1I. V. Khvorostyanaya2V. V. Vikentyev3G. I. Barilo4T. F. Tremasova5Московская медицинская академия им. И.М.СеченоваМосковская медицинская академия им. И.М.СеченоваМосковский государственный медико-стоматологический университетМосковский государственный медико-стоматологический университетГородская клиническая больница № 70 г. Москвы. МоскваГородская клиническая больница № 70 г. Москвы. МоскваAim. To study the effects of the fixed combination trandolapril 2 mg + verapamil 120 mg medication on endothelial function in patents with Stage II-III essential arterial hypertension (AH). Material and methods. In total, 39 AH patients were examined (mean age 66,7±6,9 years; Stage II and III AH – in 41,0% and 59,0%, respectively). At baseline and during the treatment phase, blood pressure (BP) measurement, 24-hour BP monitoring (BPM), and endothelium-dependent vasodilatation (EDVD) assessment were performed. All patients received the fixed combination trandolapril 2 mg + verapamil 120 mg in the dose of 1 tablet once a day, in the morning; if after four weeks, routinely measured BP did not achieve target levels (<140/90 mm Hg), the dose was increased up to 2 tablets once a day. The follow-up period lasted for 24 weeks. Results. A significant reduction (p<0,05) in “office” systolic and diastolic BP (SBP, DBP) levels – by 36,3 and 24,4 mm Hg, respectively – was observed. At baseline, endothelial dysfunction was registered in 15 individuals. After 24 weeks of the therapy, EDVD normalized in 9 out of 15 patients (60,0%), and improved in other 6 (40,0%). Conclusion. The fixed-dose combined medication, the fixed combination trandolapril 2 mg + verapamil 120 mg, administered to patients with Stage II-III AH for 24 weeks, significantly reduced SBP and DBP levels and improved endothelial function.https://cardiovascular.elpub.ru/jour/article/view/2033эссенциальная артериальная гипертензиякомбинированная антигипертензивная терапияфиксированные комбинациидисфункция эндотелия |
| spellingShingle | O. D. Ostroumova O. V. Zhukova I. V. Khvorostyanaya V. V. Vikentyev G. I. Barilo T. F. Tremasova Effects of a fixed-dose combination of ACE inhibitor and nondihydropyridine calcium antagonist on endothelial dysfunction in patients with essential arterial hypertension Кардиоваскулярная терапия и профилактика эссенциальная артериальная гипертензия комбинированная антигипертензивная терапия фиксированные комбинации дисфункция эндотелия |
| title | Effects of a fixed-dose combination of ACE inhibitor and nondihydropyridine calcium antagonist on endothelial dysfunction in patients with essential arterial hypertension |
| title_full | Effects of a fixed-dose combination of ACE inhibitor and nondihydropyridine calcium antagonist on endothelial dysfunction in patients with essential arterial hypertension |
| title_fullStr | Effects of a fixed-dose combination of ACE inhibitor and nondihydropyridine calcium antagonist on endothelial dysfunction in patients with essential arterial hypertension |
| title_full_unstemmed | Effects of a fixed-dose combination of ACE inhibitor and nondihydropyridine calcium antagonist on endothelial dysfunction in patients with essential arterial hypertension |
| title_short | Effects of a fixed-dose combination of ACE inhibitor and nondihydropyridine calcium antagonist on endothelial dysfunction in patients with essential arterial hypertension |
| title_sort | effects of a fixed dose combination of ace inhibitor and nondihydropyridine calcium antagonist on endothelial dysfunction in patients with essential arterial hypertension |
| topic | эссенциальная артериальная гипертензия комбинированная антигипертензивная терапия фиксированные комбинации дисфункция эндотелия |
| url | https://cardiovascular.elpub.ru/jour/article/view/2033 |
| work_keys_str_mv | AT odostroumova effectsofafixeddosecombinationofaceinhibitorandnondihydropyridinecalciumantagonistonendothelialdysfunctioninpatientswithessentialarterialhypertension AT ovzhukova effectsofafixeddosecombinationofaceinhibitorandnondihydropyridinecalciumantagonistonendothelialdysfunctioninpatientswithessentialarterialhypertension AT ivkhvorostyanaya effectsofafixeddosecombinationofaceinhibitorandnondihydropyridinecalciumantagonistonendothelialdysfunctioninpatientswithessentialarterialhypertension AT vvvikentyev effectsofafixeddosecombinationofaceinhibitorandnondihydropyridinecalciumantagonistonendothelialdysfunctioninpatientswithessentialarterialhypertension AT gibarilo effectsofafixeddosecombinationofaceinhibitorandnondihydropyridinecalciumantagonistonendothelialdysfunctioninpatientswithessentialarterialhypertension AT tftremasova effectsofafixeddosecombinationofaceinhibitorandnondihydropyridinecalciumantagonistonendothelialdysfunctioninpatientswithessentialarterialhypertension |